We are the people of the Tracers in Molecular Imaging group!
I got my M.Sc. degree in Biochemistry from University of Kuopio in 1999 and my Ph.D. in Biochemistry/Chemistry in Biosciences in 2003. Topic of my doctoral dissertation was synthesis and evaluation of new tropane analogues for brain imaging with SPECT. I worked as a postdoctoral researcher in Vrije Universiteit/VU Medisch Centrum in Amsterdam and in Karolinska Institutet in Stockholm. As a postdoctoral researcher, I contributed to several preclinical and clinical research projects in development of new carbon-11 -labeled and fluorine-18 -labeled PET radiopharmaceuticals for brain imaging.
I started in University of Helsinki in 2007, first as a postdoctoral researcher and from 2008 as a principal investigator in radiopharmaceutical chemistry and as a group leader of the Tracers for Molecular Imaging (TRIM) research group, the TRIM team. I held an Academy Research Fellowship during 2010 – 2016. In 2017, I was appointed as Associate Professor (tenure-track) in Radiopharmaceutical Chemistry at University of Helsinki. My main research interest is to develop quantitative radiotracer methods for following nanoparticle mediated drug delivery non-invasively with SPECT and PET imaging. Especially, I am interested in development of bioorthogonal small molecular tracers for pretargeted imaging. However, due to my previous background in brain research, I never lose an opportunity to work with new radiotracer candidates for brain imaging or new interesting molecular targets in the brain.
ORCID iD: http://orcid.org/0000-0002-5943-3105
I got my M.Sc. degree at Helsinki University of Technology (presently Aalto University), majoring in nuclear and energy techniques and mathematics. After that, I continued my studies in University of Jyväskylä and joined the gammaspectroscopy group at the accelerator laboratory of its Department of Physics. My Ph.D. thesis is about coexisting nuclear shapes in neutron-deficient polonium nuclei. The Ph.D. was followed by one year of post doc at GSI, Darmstadt, Germany, working with nuclear reaction studies. In the year 2001, I was appointed to my present position at the Department of Chemistry. My work includes technical support and development of the nuclear spectrometers and the cyclotron, as well as teaching of nuclear spectrometry. I also act as a radiation safety officer for the department. My research project is on radionuclide-implanted nanoparticles for theranostic applications. I’m also involved in in-situ studies of retention of radionuclides in rock matrix.
I am an Acedemy of Finland Research Fellow (2018–2023) and a junior group leader in training, but have been a member of the TRIM team since the beginning of my Ph.D. studies in Radiochemistry in 2007. My Ph.D. studies were focused on the development of fluorine-18 -radiolabeled molecular imaging tools for the in vivo evaluation of porous silicon drug delivery systems, which sparked the interest to remain in the "margins" of radiopharmaceutical chemistry developing new molecular imaging tools to facilitate the translation of promising nanoscale drug delivery systems and materials from in vitro cell models to preclinical models. After my Ph.D., I trained years 2014–2016 under the mentorship of Dr. Jason S. Lewis as a postdoctoral fellow at the Department of Radiology at the Memorial Sloan Kettering Cancer Center, New York, NY, USA. Upon return to Helsinki, my research has focused on the development and evaluation of multimodality imaging probes for nanocrystalline cellulose (CNC) and lignin drug delivery systems, and tumor-infiltrating lymphocytes in cancer immunotherapy. I especially enjoy the multidisciplinary nature of radiopharmaceutical chemistry, which allows me to combine radiochemistry, biochemistry, cell biology, physiology, histology, and laboratory animal science without having to pick one discipline! My research is currently funded by the Academy of Finland and a three-year research grant from the University of Helsinki, and I am a supervisor of three Ph.D. students at the Doctoral Programme for Chemistry and Molecular Sciences (CHEMS-DP). I am the Head of Preclinical Evaluation of the TRIM Group and oversee the laboratory animal and cell culture facilities for the group.
I work as a postdoctoral researcher at the Department of Chemistry. I have done my PhD in radiopharmaceutical chemistry and development of new radiotracers/labelling methods, especially for imaging of central nervous system and cancer by PET and SPECT, are still close to my heart. My versatile job description includes both teaching and research in radio(pharmaceutical) chemistry. I am a principal investigator in an EU-project (a Modular European Education and Training concept in nuclear and radiochemistry, MEET-CINCH) that aims at e.g. increasing the nuclear awareness and developing high quality teaching materials/courses in nuclear and radiochemistry. I also represent UH (radiochemistry) at the European Network on Nuclear and Radiochemistry Education and Training (European NRC Network). At the Department of Chemistry I am a steering group member of the Master’s programme in Chemistry and Molecular Sciences. My current duties in TRIM team include coordination and development of services in radiopharmaceutical chemistry, as well as production of radiotracers for Helsinki In Vivo Animal Imaging Platform (HAIP) and for industrial customers.
ORCID iD: http://orcid.org/0000-0002-2856-9034
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During my doctoral research at Georgetown University I developed Gd(III)-peptide based activatable MRI contrast agents for kinases overexpressed in cancer and Rh-phosphine based catalysts to steer stereoselectivity in hydroformylation reactions. I was also involved in teaching general, physical and organic chemistry laboratory and recitation sessions along with mentoring undergraduate students. In my postdoctoral research at Memorial Sloan Kettering Cancer Center I worked on numerous preclinical projects. I developed activatable optical contrast agents and targeted drug delivery techniques using Cerenkov luminescence. I used PET imaging to evaluate efficacy of vascular targeted photodynamic therapy in prostate cancer. I performed clinical research to evaluate the efficacy of Cerenkov imaging device to detect tumors in patients undergoing PET/CT.
My current project is to build modular and standardized e-learning content on application of nuclear medicine in cancer diagnosis and therapy for the EU commission MEET-CINCH project. I am also responsible for coordination of the Radiopharmaceutical Chemistry services for the Helsinki In Vivo Animal Imaging Platform (HAIP).
Professionally I am interested in innovation, entrepreneurship and business development related to diagnosis and therapy of cancer. Personally I enjoy snowboarding, soccer and motorcycles!
I have started at the TRIM group in 2017 as a postdoctoral researcher. The research interests of mine are molecular imaging and currently in particular the development of radiopharmaceuticals for pretargeted PET imaging of cancer.
My doctoral studies (Ph.D. of clinical physiology and nuclear medicine) at the Turku PET Centre, the University of Turku and the Drug Discovery Graduate School focused on the development of 68Ga-labeled imaging agents for cancer and inflammation. My knowledge on pharmacy, chemistry and biomedicine is based on the training for M.Sc. in Health Biosciences (the University of Turku) and B.Sc. in Pharmacy (the University of Helsinki). I have also worked in industry and pharmacies.
My experience spans from drug development to medication, including preparation, evaluation in disease models and delivery of pharmaceuticals for customers. Meeting patients keeps you focused on why it is important to develop better imaging agents for cancer diagnosis and the advancement of personalized medicine.
The emphasis of my research has been geared towards the theme of development of pharmaceutically significant chemical entities of supramolecular polymers and drug conjugation, as well as macromolecular-based drug delivery system. During my M.Sc. studies at the Department of Bioengineering, University of Tokyo, I have been working with glucose decorated anticancer drug-loaded pH-responsive polymeric micelles directed to enhance targeting of glycolytics tumor via glucose transporter. Currently, I am pursuing a Ph.D. degree at the Doctoral Programme for Chemistry and Molecular Sciences (CHEMS-DP) under the supervision of Dr. Mirkka Sarparanta and Dr. Anu Airaksinen focusing on the development of multimodality molecular imaging tools for the evaluation of drug delivery systems based on nanocrystalline nanocellulose (CNC), which is an emerging green biomaterial for drug delivery applications.
ORCID iD: http://orcid.org/0000-0003-2520-2146
I originally come from beautiful Greece. I have also lived abroad for quite a long period of time. I did my bachelor’s and master’s studies in chemistry and bioimaging sciences in England where I participated in bioinorganic, analytical and molecular biology projects. Later, I decided to live in Hong Kong to get the Asian cultural experience. There I obtained my second master’s degree which was based on organic synthesis and photophysical measurements of theranostic agents. Moreover, in the beginning of this year (2017), I took the challenge and moved to Finland. Here, I will conduct research in radiochemistry within the TRIM team, synthesizing radiopharmaceuticals for PET/ SPECT imaging which is my greatest interest. My first project is based on a gallium-68 pretargeting probe for PET imaging. Apart from research and travelling, I like keeping a healthy lifestyle, listening to live music and spending time with my family and friends.
I started my Ph.D studies in January 2016 and my topic is synthesis of In-111 and Ga-68 radiopharmaceuticals via biorthogonal click reactions, more especially reactions with tetrazine-DOTA molecules. I have also done my bachelor and master theses in the TRIM team. I started as a summer worker 2013 and have been group member since then. During this time I have worked with different nuclides e.g. F-18 and I-131. I have been trained to operate cyclotron and I have permission to work with animals (mice and rats).
I started my Ph.D in the radiopharmaceutical group TRIM team in February 2017. My research is focused on utilizing click chemisty reactions of fluorine-18 radiopharmaceuticals in kit labeling for PET-imaging applications.
My background is in organic chemistry. I did my B.Sc in medicinal chemistry of the topic: ”Optimization of Claisen rearrangement” in the pharmaceutical industry. I did my Master’s thesis as a joint project of organic and radiochemistry laboratories, during which I started my work in TRIM team. After my thesis I also worked as a research assistant in TRIM team for three months. I worked as a research assistant for two months in the organic laboratory synthesizing new drug candidates under the supervision of Professor Wähälä in the University of Helsinki.
My research interests are in the area of PET- and SPECT-imaging, pharmaceuticals, pretargeting and theranostics.
I started my Bachelor of Science in 2014 at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jagiellonian University in Krakow, Poland. I worked under the supervision of Professor Malgorzata Baranska and investigated wide range of applications for biological samples analysis based on spectroscopic techniques such as Infrared and Raman spectroscopies. Moreover, I was an intern at Raman Imaging Group, Jagiellonian Centre for Experimental Therapeutics. Working there has encouraged me to continue my studies in the field of spectroscopic methods development.
In 2017, I have participated to the Advanced Spectroscopy in Chemistry (ASC) European Erasmus Mundus Master programme where I continue my master studies at University of Lille1, France. In the final year of my master studies, I have relocated to pursue my master thesis and study some specialized coursework at the University of Helsinki – one of the ASC university network. I have joined the Tracers in Molecular Imaging (TRIM) group, Laboratory of Radiochemistry, Department of Chemistry since September 2018 and worked under Dr. Mirkka Sarparanta supervision. Here, I will work on my master thesis entitled ‘Label-Free and Multimodal Detection of Lignin Nanoparticles Interactions with Metastatic Melanoma Cells and Tumors In Vivo’. I will develop the spectroscopic detection method based on Coherent anti-Stokes Raman Spectroscopy (CARS) model to simultaneously detect lignin nanoparticles, drug payload, and melanoma cells.
I am a M.Sc. student at the Department of Chemistry, University of Helsinki with B.Sc. degree in pharmacy and chemistry. I have participated the TRIM group since spring 2017 to pursue my bachelor thesis on the topic of the determination of molar activity of fluorine-18 labeled radiopharmaceuticals. In 2018, I continued to work in the group as a summer trainee and research assistant for radiochemistry services. Working with the TRIM team, I have gained a lot of experience in handling and working with various radioactive nuclides, including Tc-99m, I-123 and F-18. Radiopharmaceutical chemistry has given me a versatile perspective in chemistry, which I can apply my pharmacy background into it. In the final year of my M.Sc. studies, I have decided to pursue my master thesis in the same group under the supervision of Prof. Anu Airaksinen. My thesis will be focusing on the optimization and synthesis of 18F-labeled 5-fluoro-5-deoxy-ribose (FDR) and trifluoroborate tracer ligands for biomedical applications. Moreover, both preclinical and clinical utilizations of radiotracers and drug metabolism studies are also my favorite research interests.
I am currently a M.Sc. student at the Department of Chemistry with a previous Bachelor's degree in Laboratory Sciences. I have a taste of multidisciplinary research, especially those combining chemistry with biomedical and physical aspects or instrumentation for practical outcomes. I joined the TRIM team in 2018 as a summer trainee and now I continue to pursue my master's thesis with Dr. Kerttuli Helariutta and Prof. Anu Airaksinen focusing on the production of clinically scandium radioisotopes with the low-energy cyclotron and subsequent separation and purification of the products.
I graduated my bachelor of laboratory sciences at Metropolia University of Applied Sciences. My bachelor thesis was about the determination of BTEX-compounds in industrial wastewater by Headspace gas chromatography with flame ionization detection (HS-GC-FID) method. Currently, I am pursuing my master degree at the Department of Chemistry, University of Helsinki. In 2018, I had joined the ion exchange group at the radiochemistry laboratory as research assistant working on various projects involving selective inorganic ion exchangers. After that, I have joined the TRIM team in early 2019 for working on my master thesis. My project will be on the topic of development of radio-iodinated sugar analogues for probing carbohydrate metabolism in plants by multimodality imaging methodology. Radiopharmaceutical chemistry fascinates me because of its multidisciplinary sciences and I am particularly interested in PET and SPECT imaging modalities.
M.Sc. Marcus Lindgren, summer trainee (2018)
M.Sc. Osku Alanen, research assistant (2018)
Dr. Outi Keinänen, postgraduate student (2013–2018)
Dr. Sanjeev Ranjan, postdoctoral researcher (2017–2018)
Dr. Ulrika Jakobsson, postdoctoral researcher (2015–2018)
Kirsi Kepsu, bachelor student (2018)
Anita Nurminen, bachelor student (2018)
Danni Ramdhani, visiting researcher (2017–2018)
Vilma Jallinoja, M.Sc. student (2017)
Pauline Lang, Erasmus M.Sc. student (2017)
Chiara Timperanza, Erasmus M.Sc. student (2017)