I got my M.Sc. degree in Biochemistry from University of Kuopio in 1999 and my Ph.D. in Biochemistry/Chemistry in Biosciences in 2003. Topic of my doctoral dissertation was synthesis and evaluation of new tropane analogues for brain imaging with SPECT. I worked as a postdoctoral researcher in Vrije Universiteit/VU Medisch Centrum in Amsterdam and in Karolinska Institutet in Stockholm. As a postdoctoral researcher, I contributed to several preclinical and clinical research projects in development of new carbon-11 -labeled and fluorine-18 -labeled PET radiopharmaceuticals for brain imaging.
I started in University of Helsinki in 2007, first as a postdoctoral researcher and from 2008 as a principal investigator in radiopharmaceutical chemistry and as a group leader of the Tracers for Molecular Imaging (TRIM) research group, the TRIM team. I held an Academy Research Fellowship during 2010 – 2016. In 2017, I was appointed as Associate Professor (tenure-track) in Radiopharmaceutical Chemistry at University of Helsinki. My main research interest is to develop quantitative radiotracer methods for following nanoparticle mediated drug delivery non-invasively with SPECT and PET imaging. Especially, I am interested in development of bioorthogonal small molecular tracers for pretargeted imaging. However, due to my previous background in brain research, I never lose an opportunity to work with new radiotracer candidates for brain imaging or new interesting molecular targets in the brain.
ORCID iD: http://orcid.org/0000-0002-5943-3105
I got my M.Sc. degree at Helsinki University of Technology (presently Aalto University), majoring in nuclear and energy techniques and mathematics. After that, I continued my studies in University of Jyväskylä and joined the gammaspectroscopy group at the accelerator laboratory of its Department of Physics. My Ph.D. thesis is about coexisting nuclear shapes in neutron-deficient polonium nuclei. The Ph.D. was followed by one year of post doc at GSI, Darmstadt, Germany, working with nuclear reaction studies. In the year 2001, I was appointed to my present position at the Department of Chemistry. My work includes technical support and development of the nuclear spectrometers and the cyclotron, as well as teaching of nuclear spectrometry. I also act as a radiation safety officer for the department. My research project is on radionuclide-implanted nanoparticles for theranostic applications. I’m also involved in in-situ studies of retention of radionuclides in rock matrix.
I am currently a postdoctoral fellow and a junior group leader in training, but have been a member of the TRIM team since the beginning of my Ph.D. studies in Radiochemistry in 2007. My Ph.D. studies were focused on the development of fluorine-18 -radiolabeled molecular imaging tools for the in vivo evaluation of porous silicon drug delivery systems, which sparked the interest to remain in the "margins" of radiopharmaceutical chemistry developing new molecular imaging tools to facilitate the translation of promising nanoscale drug delivery systems and materials from in vitro cell models to preclinical models. After my Ph.D., I trained years 2014—2016 under the mentorship of Dr. Jason S. Lewis as a postdoctoral fellow at the Department of Radiology at the Memorial Sloan Kettering Cancer Center, New York, NY, USA. Upon return to Helsinki, my research has focused on the development and evaluation of multimodality imaging probes for nanocrystalline cellulose (CNC) and lignin. I especially enjoy the multidisciplinary nature of radiopharmaceutical chemistry, which allows me to combine radiochemistry, biochemistry, cell biology, physiology, histology, and laboratory animal science without having to pick one discipline! My research is currently funded by the Academy of Finland and a three-year research grant from the University of Helsinki, and I am a supervisor of three Ph.D. students at the Doctoral Programme for Chemistry and Molecular Sciences (CHEMS-DP). I am the Head of Preclinical Evaluation of the TRIM Group and oversee the laboratory animal and cell culture facilities for the group.
I work as a postdoctoral researcher at the Department of Chemistry. I have done my PhD in radiopharmaceutical chemistry and development of new radiotracers/labelling methods, especially for imaging of central nervous system and cancer by PET and SPECT, are still close to my heart. My versatile job description includes both teaching and research in radio(pharmaceutical) chemistry. I am a principal investigator in an EU-project (a Modular European Education and Training concept in nuclear and radiochemistry, MEET-CINCH) that aims at e.g. increasing the nuclear awareness and developing high quality teaching materials/courses in nuclear and radiochemistry. I also represent UH (radiochemistry) at the European Network on Nuclear and Radiochemistry Education and Training (European NRC Network). At the Department of Chemistry I am a steering group member of the Master’s programme in Chemistry and Molecular Sciences. My current duties in TRIM team include coordination and development of services in radiopharmaceutical chemistry, as well as production of radiotracers for Helsinki In Vivo Animal Imaging Platform (HAIP) and for industrial customers.
ORCID iD: http://orcid.org/0000-0002-2856-9034
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I obtained my doctoral degree in nuclear physics in 2013 at the Department of Physics, University of Jyväskylä. My research background is within the field of nuclear-structure research at the neutron drip line. In my research I have performed nuclear spectroscopy with large germanium-detector arrays together with recoil separators and complex ancillary-detector systems. Currently I am a postdoctoral researcher working in the NanoRad project. My main research interests lie in the usage of mesoporous silicon nanoparticles together with emerging radionuclides for theranostic purposes. On the side my tasks include maintenance of the cyclotron and nuclear safeguards issues. My teaching consists mainly of laboratory exercises in the nuclear spectrometry course.
I graduated in Human Biology from All India Institute of Medical Sciences (AIIMS), New Delhi, India. Thereafter, I obtained my masters’ degree in Biotechnology from Indian Institute of Technology (IIT) at Roorkee. My Ph.D. in Nanomedicine and Biomedical engineering was completed in August 2012 at Aalto University, Finland under the guidance of Prof. Paavo Kinnunen. My Ph.D. research was focused on developing Multifunctional Liposome Nanoparticles for targeted drug delivery, gene delivery and magnetic imaging to selected targets of the inner ear for developing means of treatment to the hearing loss. I continued in the same lab as a postdoc and developed novel endosomolytic peptides for enhancing gene delivery. Thereafter, I joined the research group of Prof. Elina Ikonen (University of Helsinki, Finland) studying intracellular cholesterol trafficking where I investigated lipid droplets heterogeneity using nonlinear optical microscopy techniques based on coherent anti-Stokes Raman scattering (CARS) and third-harmonic generation (THG). To further pursue my interest in nanoparticle-based targeted drug delivery research, I joined the TRIM research group in 2014, since I have developed radiolabeled silicon and polymer-based nanoparticles for targeted drug delivery to the ischemic heart and in cancer animal models in a close collaboration with Prof. Heikki Ruskoaho and Dr. Hélder Santos from the Faculty of Pharmacy, University of Helsinki. I was visiting Health Sciences North, Sudbury, Ontario, Canada in 2017 for developing VR23 drug formulation for safe and effective anticancer therapies. I rejoined the TRIM group in September 2017 and I am currently studying radionuclide-implanted silicon nanoparticles in preclinical models intended for cancer theranostics with Dr. Kerttuli Helariutta.
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I have started at the TRIM group in 2017 as a postdoctoral researcher. The research interests of mine are molecular imaging and currently in particular the development of radiopharmaceuticals for pretargeted PET imaging of cancer.
My doctoral studies (Ph.D. of clinical physiology and nuclear medicine) at the Turku PET Centre, the University of Turku and the Drug Discovery Graduate School focused on the development of 68Ga-labeled imaging agents for cancer and inflammation. My knowledge on pharmacy, chemistry and biomedicine is based on the training for M.Sc. in Health Biosciences (the University of Turku) and B.Sc. in Pharmacy (the University of Helsinki). I have also worked in industry and pharmacies.
My experience spans from drug development to medication, including preparation, evaluation in disease models and delivery of pharmaceuticals for customers. Meeting patients keeps you focused on why it is important to develop better imaging agents for cancer diagnosis and the advancement of personalized medicine.
The emphasis of my research has been geared towards the theme of development of pharmaceutically significant chemical entities of supramolecular polymers and drug conjugation, as well as macromolecular-based drug delivery system. During my M.Sc. studies at the Department of Bioengineering, University of Tokyo, I have been working with glucose decorated anticancer drug-loaded pH-responsive polymeric micelles directed to enhance targeting of glycolytics tumor via glucose transporter. Currently, I am pursuing a Ph.D. degree at the Doctoral Programme for Chemistry and Molecular Sciences (CHEMS-DP) under the supervision of Dr. Mirkka Sarparanta and Dr. Anu Airaksinen focusing on the development of multimodality molecular imaging tools for the evaluation of drug delivery systems based on nanocrystalline nanocellulose (CNC), which is an emerging green biomaterial for drug delivery applications.
ORCID iD: http://orcid.org/0000-0003-2520-2146
I’m a PhD student working under the supervision of Anu Airaksinen and Mirkka Sarparanta. My PhD project is about utilizing bioorthogonal chemistry in pretargeting. I do mainly fluorine-18 chemistry but I also have experience working with iodine-125, technetium-99m, zirconium-89, and gallium-68. My work has focused on pretargeting nanoparticles and antibodies. I’m interested in the design, synthesis, and preclinical evaluation of new radiopharmaceuticals in molecular imaging, especially when combined to the exciting bioorthogonal chemistry.
When I’m not in the lab, I like to travel, read and see what’s new on Netflix.
I originally come from beautiful Greece. I have also lived abroad for quite a long period of time. I did my bachelor’s and master’s studies in chemistry and bioimaging sciences in England where I participated in bioinorganic, analytical and molecular biology projects. Later, I decided to live in Hong Kong to get the Asian cultural experience. There I obtained my second master’s degree which was based on organic synthesis and photophysical measurements of theranostic agents. Moreover, in the beginning of this year (2017), I took the challenge and moved to Finland. Here, I will conduct research in radiochemistry within the TRIM team, synthesizing radiopharmaceuticals for PET/ SPECT imaging which is my greatest interest. My first project is based on a gallium-68 pretargeting probe for PET imaging. Apart from research and travelling, I like keeping a healthy lifestyle, listening to live music and spending time with my family and friends.
I started my Ph.D studies in January 2016 and my topic is synthesis of In-111 and Ga-68 radiopharmaceuticals via biorthogonal click reactions, more especially reactions with tetrazine-DOTA molecules. I have also done my bachelor and master theses in the TRIM team. I started as a summer worker 2013 and have been group member since then. During this time I have worked with different nuclides e.g. F-18 and I-131. I have been trained to operate cyclotron and I have permission to work with animals (mice and rats).
I started my Ph.D in the radiopharmaceutical group TRIM team in February 2017. My research is focused on utilizing click chemisty reactions of fluorine-18 radiopharmaceuticals in kit labeling for PET-imaging applications.
My background is in organic chemistry. I did my B.Sc in medicinal chemistry of the topic: ”Optimization of Claisen rearrangement” in the pharmaceutical industry. I did my Master’s thesis as a joint project of organic and radiochemistry laboratories, during which I started my work in TRIM team. After my thesis I also worked as a research assistant in TRIM team for three months. I worked as a research assistant for two months in the organic laboratory synthesizing new drug candidates under the supervision of Professor Wähälä in the University of Helsinki.
My research interests are in the area of PET- and SPECT-imaging, pharmaceuticals, pretargeting and theranostics.
I completed my M.Sc. studies in analytical and radiopharmaceutical chemistry at the University of Helsinki recently with a thesis project focusing on the development of a novel fluorine-18 labeled Prostate-Specific Membrane Antigen (PSMA) ligand and comparing it to gallium-68 labeled PSMA ligand currently in clinical use for PET imaging of prostate cancer. At present, I am working as a research assistant for the Academy of Finland key project of Prof. Anu Airaksinen. I have also worked as a research assistant in the TRIM team during the summer of 2016, where I worked mainly with iodine-125 and applications related to histology and autoradiography. Before that, I did my B.Sc. in Laboratory Sciences at Tampere University of Applied Sciences, where my focus was in analytical chemistry and biosciences.
Jarkko Lampuoti (Left)
I am currently a M.Sc. student at the Department of Chemistry with a previous Bachelor's degree in the field of Laboratory Sciences and a taste for multidisciplinary research topics. During summer 2018, I am going to work with the synthesis of carbohydrate-based radioiodinated tracer, porous silicon nanoparticles, and aim to familiarize myself with the cyclotron operation.
Iida Hirsso (Middle)
I am a M.Sc. student at the University of Helsinki with B.Sc. degrees in pharmacy and chemistry. I did my bachelor thesis with the TRIM team in the spring 2017 on the topic of the determination of molar activity of fluorine-18 labeled radiopharmaceuticals. In my M.Sc. studies I will be focusing more on radiopharmaceutical and synthetic chemistry of the radiotracers. As a kick-off, I will be working as a trainee in order to familiarize myself to the field during summer 2018. My responsibilities are mainly to assist with organic synthesis of the radiotracers in the ongoing Academy of Finland key project of Prof. Airaksinen. In addition, I am also maintaining the laboratory inventory and calibrations of the instruments with other summer trainees.
Marcus Lindgren (Right)
I am a graduated M.Sc. from Radiochemistry, Department of Chemistry, University of Helsinki. I have always been interested in nature and its phenomena. My study in radiochemistry started in 2015 with bachelor thesis in the ion exchange research group where I worked as a research assistant. In 2017, I started to do my master thesis in Dr. Merja Lusa´s microbiology and biosphere research group and later continued as a research assistant. During those times, I got valuable experience in doing experiments with living bacteria. In addition, I have familiarized myself with many methodologies and techniques used in microbiology experimentations, including 16 S rRNA gene analyses used in bacterial phylogenetic studies. During this summer, I am happy to join TRIM team as a research assistant in the Academy of Finland key project where I can learn more about radiopharmaceutical chemistry.
Pauline Lang, Erasmus M.Sc. student (2017)
Chiara Timperanza, Erasmus M.Sc. student (2017)
Vilma Jallinoja, M.Sc. student (2017)
Danni Ramdhani, visiting researcher (2017-2018)