Due to immunological memory, past environmental exposures shape present immune function. These exposures do not only include factors that impact adaptive immune memory, but also agents that shape innate immune responses for prolonged periods of time, moulding susceptibility to chronic inflammatory diseases including allergies and autoimmunity. Within Systems Immunology research, we are interested in elucidating the mechanistic basis of how different environmental exposures, including environmental and endogenous microbes, nanomaterials and chemicals, affect human wellbeing.