Research Program in Systems Oncology (ONCOSYS) consists of basic, translational and clinical researchers who use cutting-edge measurement technology, patient data and AI methods in cancer research and oncology. The overall objective of ONCOSYS is to understand the underlying causes of cancer progression or treatment resistance, and to develop effective diagnostic, prognostic and therapeutic approaches.
1) Ensure availability of high-quality clinical datasets, including electronic health records (EHR),
tissue materials, registries, digital imaging biobanks, and prospective and retrospective patient
cohorts;
2) Develop artificial intelligence (AI) infrastructure that connects basic researchers and clinicians,
and enables the use of data in research and clinical decision making;
3) Identify and functionally verify molecular drivers of treatment resistance using single-cell
sequencing, ex vivo assays, in vivo experiments and high-throughput drug screening;
4) Apply AI algorithms to predict treatment response and adverse events based on molecular, imaging
and pathophysiological data;
5) Design and implement researcher-initiated prospective trials based on the validated results
emerging from ONCOSYS.