Regenerative Cardiac Pharmacology

Talman Lab

As a part of the Regenerative Pharmacology Unit of the Drug Research Program, our group aims at discovering new ways to treat heart diseases by investigating the molecular mechanisms of cardiac regeneration and thereby identifying new potential drug targets. In particular, we are interested in two cell types: cardiomyocytes, i.e. heart muscle cells, and vascular endothelial cells, and we aim to find ways to promote cardiomyocyte renewal after a myocardial infarction. We are also interested in finding treatments that inhibit pathological cardiac remodelling: hypertrophy (thickening) and fibrosis (stiffening) of the left ventricular wall. We develop, screen and characterise new compounds with potential to enhance the regenerative capacity of the heart or to inhibit cardiac remodelling.

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