Research

 

Websarjakuva

OTONKOSKI LAB PROJECTS

  • Nuclear reprogramming based on regulation of endogenous genes with CRISPR-Cas9.
  • The reprogramming capacity of earliest human embryonic transcription factors
  • Differentiation of human pluripotent stem cells into functional pancreatic endocrine cells
  • Pathogenetic mechanisms of beta-cell failure in monogenic and polygenic forms of diabetes
  • Development of new approaches for beta-cell regeneration and replacement
  • Pharmacological and genetic induction of neural cells for regenerative purposes