Publications

Professor Mikael Knip, the director of the PEDIA-research group,was selected for  the annual Highly Cited Researchers 2021 list in his chosen field. The annual list identifies researchers who demonstrated significant influence in their chosen field or fields through the publication of multiple highly cited papers during the last decade. Their names are drawn from the publications that rank in the top 1% by citations for field and publication year in the Web of Science citation index.

Web of Science indexing and search service covers peer-reviewed published research articles especially in the natural sciences and medicine.

Latest publications contain publications by Professor Mikael Knip. Selected publications contain the most important papers since 2014. Dissertations contain doctoral thesis done within the PEDIA group and supervised by Professor Mikael Knip and/or Professor Outi Vaarala.

Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies. Nat Commun 2024; 15: 3810.

SARS-CoV-2 and type 1 diabetes in Finnish children. Lancet Diabetes Endocrinol 2023; 11: 251-260.

Mobile genetic elementsfrom the maternal microbiome shape infant gut microbial assembly and metabolism. Cell 2022; 185; 4921-4936.

Heterogeneity of type 1 diabetes at diagnosis supports existence of age-related endotypes. Diabetes Care 2022; 45: 871-879.

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nat Microbiol 2019; 3: 470-479 . 

Early detection of peripheral blood cell signature in children developing beta-cell autoimmunity at a young age. Diabetes 2019; 68: 2024-2034.                         

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science 2019; 366: 599-606.

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial. JAMA 2018; 319: 38-48.

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial. Gastroenterology 2017; 153: 961-970.

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity. Diabetologia 2017; 60: 424-431.

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children. Proc Natl Acad Sci U S A 2017; 114: E6166-E6175.

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility. Diabetologia 2017; 60: 1284-1293.

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity. Diabetologia 2017; 60: 1223-1233.

Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies. Diabetes 2017: 66: 437-447.

Natural history of the infant gut microbiome and impact of antibiotic treatments on strain-level diversity and stability. Sci Transl Med 2016; 8: 343ra81.

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes. Sci Rep 2016;6: 29058.

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell 2016; 165: 1551.

The role of the intestinal microbiota in type 1 diabetes mellitus. Nature Rev Endocrinol 2016; 12: 154-167.

ConStrains identifies microbial strains in metagenomic datasets. Nat Biotechnol 2015; 33: 1045-1052.

Oral glucose tolerance test and random plasma glucose in prediction of type 1 diabetes. Diabetologia 2015; 58: 1787-1796.

Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility. Diabetes 2015; 64: 2265-2278. 

HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk. Diabetes 2015; 64: 1719-1727.

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host & Microbe 2015; 17: 260-273.

Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans. J Immunol 2015 Jan 1; 194:68-75.

Microbial exposures in infancy and subsequent appearance of type 1 diabetes-associated autoantibodies: a cohort study. JAMA Pediatrics 2014; 168: 755-763.

Hydrolyzed Infant Formula and Early β-Cell Autoimmunity - A Randomized Clinical Trial. JAMA 2014; 311: 2279-2287.

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes 2014; 63: 2402-2414.

Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes. Diabetes 2014; 63: 446-455.

New Insights into the Epidemiology of Type 1 Diabetes in Children in Finland.  Anna Parviainen 2025.

Sex, family history, and seasonal variation in relation to the phenotype and genotype at diagnosis of type 1 diabetes. Maaret Turtinen 2021.

The Effects of Environmental and Dietary Factors on the Development of the Immune System in Children at Genetic Risk of Type 1 Diabetes. Terhi Ruohtula 2021. 

Early-life infections, medications, and atopic sensitization in the development of immune-mediated diseases in Finland, Estonia, and Russian Karelia. Neea Mustonen 2020. 

Dynamics of the disease process leading to type 1 diabetes in children with HLA-conferred disease susceptibility. Petra Pöllänen 2020. 

Studies on immune regulation in the development of human type 1 diabetes. Linnea Hartwall 2020.

HLA and non-HLA genes and familiar predisposition to autoimmune diseases in families with a child affected by type 1 diabetes. Anna Parkkola 2018.

Humoral beta-cell autoimmunity, AGER gene polymorphism, and circulating soluble RAGE in pre-clinical and clinical type 1 diabetes. Kirsi Salonen 2016.

Intrauterine and postnatal growth in children with HLA-conferred susceptibility to type 1 diabetes. Aleksander Peet 2015.

The Development of Immune Responses and Allergy in Children from Farming and Non-farming Environments. Laura Orivuori 2015.

Studies on Antigen-Presenting Cells in Type 1 Diabetes and Crohn's Disease - with Special Emphasis on Dendritic Cells. Janne K. Nieminen 2013.

Studies of Immune Regulation in Type 1 Diabetes. Jarno Honkanen 2010.

The development of immune responses and gut microbiota in children at genetic risk of type 1 diabetes. Kristiina Luopajärvi 2010.

Assessment of Risk for Type 1 Diabetes in Children of Affected Families and in the General Population: Role of Immunological and Metabolic Markers. Heli Siljander 2010.