Publications

Latest publications contain publications by professor Mikael Knip. Selected publications contain the most important papers since 2014. Dissertations contain doctoral thesis done within the PEDIA group and supervised by Professor Mikael Knip and/or Professor Outi Vaarala.

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Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial. JAMA 2018; 319: 38-48.

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial. Gastroenterology 2017; 153: 961-970.

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity. Diabetologia 2017; 60: 424-431.

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children. Proc Natl Acad Sci U S A 2017; 114: E6166-E6175.

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility. Diabetologia 2017; 60: 1284-1293.

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity. Diabetologia 2017; 60: 1223-1233.

Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies. Diabetes 2017: 66: 437-447.

Natural history of the infant gut microbiome and impact of antibiotic treatments on strain-level diversity and stability. Sci Transl Med 2016; 8: 343ra81.

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes. Sci Rep 2016;6: 29058.

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell 2016; 165: 1551.

The role of the intestinal microbiota in type 1 diabetes mellitus. Nature Rev Endocrinol 2016; 12: 154-167.

ConStrains identifies microbial strains in metagenomic datasets. Nat Biotechnol 2015; 33: 1045-1052.

Oral glucose tolerance test and random plasma glucose in prediction of type 1 diabetes. Diabetologia 2015; 58: 1787-1796.

Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility. Diabetes 2015; 64: 2265-2278. 

HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk. Diabetes 2015; 64: 1719-1727.

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host & Microbe 2015; 17: 260-273.

Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans. J Immunol 2015 Jan 1; 194:68-75.

Microbial exposures in infancy and subsequent appearance of type 1 diabetes-associated autoantibodies: a cohort study. JAMA Pediatrics 2014; 168: 755-763.

Hydrolyzed Infant Formula and Early β-Cell Autoimmunity - A Randomized Clinical Trial. JAMA 2014; 311: 2279-2287.

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes 2014; 63: 2402-2414.

Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes. Diabetes 2014; 63: 446-455.