Publications

Research articles & reviews.
2024

  • Karaman S*, Lehti S, Zhang C, Taskinen MR, Käkelä R, Mardinoglu A, Brorson H, Alitalo K*, Kivelä R*. Multi-omics characterization of lymphedema-induced adipose tissue resulting from breast cancer-related surgery. FASEB J. 2024 Oct 31;38(20):e70097

    * Corresponding authors

  • Antila S, Chilov D, Nurmi H, Li Z, Näsi A, Gotkiewicz M, Sitnikova V, Jäntti H, Leinonen NA, Koivisto H, Ray J, Keuters M, Sultan I, Scoyni F, Trevisan D, Wojciechowski S, Kaakinen M, Dvorakova L, Singh A, Jukkola J, Korvenlaita N, Eklund L, Koistinaho J, Karaman S, Malm T, Tanila H, Alitalo K. Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology. Nat Cardiovasc Res 2024 Mar 15,
  • Alve S, Gramolelli S, Jukonen J, Juteau S, Pink A, Manninen A, Monto E, Lackman MH, Olli Carpén, Saharinen P, Karaman S, Vaahtomeri K, Ojala PM. DLL4-Notch3-WNT5B axis is a novel mediator of bi-directional pro-metastatic crosstalk between melanoma and lymphatic endothelial cells. JCI Insight. 2024 Jan 9;9(1):e171821.
2023
  • PREPRINT: Karaman S*, Lehti S, Zhang C, Taskinen MR, Käkelä R, Mardinoglu A, Brorson H, Alitalo K*, Kivelä R*. Multi-omics characterization of lymphedema-induced adipose tissue from breast cancer patients. (2023)  

    * Corresponding authors
  • Rannikko JH, Verlingue L, Miguel MD, Pasanen A, Robbrecht D, Skytta T, Iivanainen S, Shetty S, Ma YT, Graham DM, Arora SP, Jaakkola P, Yap C, Xiang Y, Mandelin J, Karvonen MK, Jalkanen J, Karaman S, Koivunen JP, Minchom A, Hollmén M, Bono P. Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: the phase I/II first-in-human MATINS trial. Cell Rep Med, 2023, Accepted See preprint at: 
  • Paavonsalo S, Subashi Y, Lackman MH, Karaman S. Whole-mount immunofluorescence staining of blood and lymphatic vessels in murine small intestine. STAR Protoc. 2023 May 13;4(2):102310 
  • Li Z, Antila S, Nurmi H, Chilov D, Korhonen EA, Fang S, Karaman S, Engelhardt B, Alitalo K. Autoimmune neuroinflammation is not affected by the VEGFC/VEGFR3 inhibition-mediated regression and functional impairment of dural lymphatic vessels. Sci Immunol. 2023 Sci Immunol. 2023 Apr 14;8(82):eabq0375
  • Anisimov A, Fang S, Hemanthakumar KA, Örd T, Avondt KV, Chevre R, Anu Toropainen A, Singha P, Gilani H, Nguyen SD, Karaman S, Korhonen EA, Adams RH, Augustin HG, Öörni K, Soehnlein O, Kaikkonen MU, Alitalo K. The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium. Nat Cardiovasc Res. 2, 307–321 (2023).  
2022

  • Lackman MH, Subashi Y, Karaman S. A closer look at adipose tissue lymphatics and their markers. Curr Opin Hematol. 2022 Feb 25.

  • Karaman S*, Paavonsalo S, Heinolainen K, Lackman MH, Ranta A, Hemanthakumar KA, Kubota Y, Alitalo K*. Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance. J Exp Med. 2022 Mar 7;219(3):e20210565

* Corresponding authors

Paper featured on the cover of March 2022 issue

Link to related 
2021
  • Yamashita M, Niisato M, Kawasaki Y, Karaman S, Robciuc MR, Shibata Y, Ishida Y, Nishio R, Masuda T, Sugai T, Ono M, Tuder RM, Alitalo K, Yamauchi K. VEGF-C/VEGFR-3 signaling in macrophages ameliorates acute lung injury. Eur Respir J. 2021 Aug 26:2100880
  • Clement C, D'Alessandro A, Thangaswamy S, Chalmers S, Furtado R, Spada S, Mondanelli G, Ianni F, Gehrke S, Gargaro M, Manni G, Lopez Cara LC, Runge P, Tsai WL, Karaman S, Arasa J, Fernandez-Rodriguez R, Beck A, Macchiarulo A, Gadina M, Halin C, Fallarino F, Skobe M, Veldhoen M, Moretti S, Formenti S, Demaria S, Soni R, Galarini R, Sardella R, Lauvau G, Putterman C, Alitalo K, Grohmann U, Santambrogio L. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine. Nat Commun. 2021 Jul 21;12(1):4447
2020
  • Paavonsalo S, Hariharan S, Lackman MH, Karaman S. Capillary Rarefaction in Obesity and Metabolic Diseases-Organ-Specificity and Possible Mechanisms. Cells. 2020 Dec 14;9(12):E2683.
2009 - 2019
  • Yoon SY, Dieterich LC, Karaman S, Proulx ST, Bachmann SB, Sciaroni C, Detmar M. An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth. PLoS One. 2019 Jul 25;14(7):e0220341.
  • Le Joncour, Karaman S, Laakkonen P. Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish. Journal of Visualized Experiments. 2019 Apr 16;(146)
  • Schwager S, Renner S, Hemmerle T, Karaman S, Proulx ST, Fetz R, Golding-Ochsenbein AM, Probst P, Halin C, Neri D, Detmar M. Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation. JCI Insight. 2018 Dec 6;3(23)
  • Karaman S*, Leppänen VM*, Alitalo K. Vascular endothelial growth factor signaling in development and disease. Development. 2018 Jul 20;145(14). pii: dev151019
  • Roudnicky F, Yoon SY, Poghosyan S, Schwager S, Poyet C, Vella G, B. Bachmann S, Karaman S, Shin JW, Otto VI, Detmar M. Alternative transcription of a shorter, non-antiangiogenic thrombospondin-2 variant in cancer-associated blood vessels. Oncogene. 2018 May;37(19):2573-2585
  • Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen M, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, Alitalo K. Development and plasticity of meningeal lymphatic vessels. J Exp Med. 2017 Nov 15. pii: jem.20170391
  • Vaahtomeri K, Karaman S, Mäkinen T, Alitalo K. Lymphangiogenesis guidance by paracrine and pericellular factors. Genes Dev. 2017 Aug 15;31(16):1615-1634
  • Karaman S, Alitalo K. Midkine and melanoma metastasis: a malevolent mix. Dev Cell. 2017 Aug 7;42(3):205-207
  • Nitschke M, Bell A, Karaman S, Amouzgar M, Rutkowski J, Scherer P, Alitalo K, McDonald D. Retrograde lymph flow leads to chylothorax in transgenic mice with lymphatic malformations. Am J Pathol. 2017 Jul 3. pii: S0002-9440(17)30043-3
  • Gousopoulos E, Proulx ST, Bachmann SB, Dieterich LC, Scholl J, Karaman S, Bianchi R, Detmar M. An important role of VEGF-C in promoting lymphedema development. J Invest Dermatol. 2017 May 16. pii: S0022-202X(17)31534-8.
  • Karaman S, Alitalo K. ORAI1 controls the unique adjustment of lymphatics to fluid flow. Circ Res. 2017 Apr 28;120(9):1373-1375
  • Heinolainen K, Karaman S, D’Amico G, Tammela T, Sormunen R, Eklund L, Alitalo K*, Zarkada G*. VEGFR3 modulates vascular permeability by controlling VEGF/VEGFR2 signaling. Circ Res. 2017 Apr 28;120(9):1414-1425.
  • Gousopoulos E*, Karaman S*, Proulx ST, Leu K, Buschle D, Detmar M. High-fat diet in absence of obesity does not aggravate surgically-induced lymphedema in mice. Eur Surg Res. 2017;58(3-4):180-192.
  • Karaman S, Hollmén M, Yoon SY, Alkan HF, Alitalo K, Wolfrum C, Detmar M.Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice. Sci Rep. 2016 Aug 11;6:31566.
  • Ochsenbein AM, Karaman S, Proulx ST, Goldmann R, Chittazhathu J, Dasargyri A, Chong C, Leroux JC, Stanley ER, Detmar M. Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling. Angiogenesis. 2016 Oct;19(4):513-24.
  • Escobedo N*, Proulx ST*, Karaman S*, Dillard ME, Johnson N, Detmar M, Oliver G. Restoration of lymphatic function rescues obesity in Prox1 haploinsufficient mice.JCI Insight. 2016 Feb 1;1(2). pii: e85096.
  • Ochsenbein AM, Karaman S, Proulx ST, Berchtold M, Jurisic G, Stoeckli ET, Detmar M. Endothelial cell-derived Sema3A inhibits filopodia formation by blood vascular tip cells. Development. 2016 Feb 15;143(4):589-94.
  • Aspelund A, Robciuc MR, Karaman S, Mäkinen T, Alitalo K. Lymphatic system in cardiovascular medicine.Circ Res. 2016 Feb;118(3):515-30.
  • Hollmén M, Karaman S, Schwager S, Lisibach A, Christiansen AJ, Maksimow M, Varga Z, Jalkanen S, Detmar M. G-CSF-regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer. Oncoimmunology. 2015 Nov 24;5(3):e1115177.
  • Karaman S, Buschle D, Luciani P, Leroux JC, Detmar M, Proulx ST. Decline of lymphatic vessel density and function in murine skin during aging. Angiogenesis. 2015 Oct;18(4):489-98.
  • Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015 Jun 29;212(7):991-9.
  • Hollmén M, Roudnicky F, Karaman S, Detmar M. Characterization of macrophage--cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer.Sci Rep. 2015 Mar 17;5:9188.
  • Karaman S, Hollmén M, Robciuc MR, Alitalo A, Nurmi H, Morf B, Buschle D, Alkan HF, Ochsenbein AM, Alitalo K, Wolfrum C, Detmar M. Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet. Mol Metab. 2014 Dec 4;4(2):93-105.
  • Hirakawa S, Detmar M, Karaman S. Lymphatics in nanophysiology. Adv Drug Deliv Rev. 2014 Jul;74:12-8.
  • Ochsenbein AM*, Karaman S*, Jurisic G, Detmar M. The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation.Adv Anat Embryol Cell Biol. 2014;214:143-52.
  • Blum KS*, Karaman S*, Proulx ST, Ochsenbein AM, Luciani P, Leroux JC, Wolfrum C, Detmar M. Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PLoS One. 2014 Apr 8;9(4):e94713.
  • Karaman S, Detmar M. Mechanisms of lymphatic metastasis. J Clin Invest. 2014 Mar;124(3):922-8.
  • Proulx ST, Luciani P, Dieterich LC, Karaman S, Leroux JC, Detmar M. Expansion of the lymphatic vasculature in cancer and inflammation: new opportunities for in vivo imaging and drug delivery. J Control Release. 2013 Dec 10;172(2):550-7.
  • Alitalo AK, Proulx ST, Karaman S, Aebischer D, Martino S, Jost M, Schneider N, Bry M, Detmar M. VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis. Cancer Res. 2013 Jul 15;73(14):4212-21.
  • Proulx ST, Luciani P, Christiansen A, Karaman S, Blum KS, Rinderknecht M, Leroux JC, Detmar M. Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials. 2013 Jul;34(21):5128-37.
  • Iolyeva M, Karaman S, Willrodt AH, Weingartner S, Vigl B, Halin C. Novel role for ALCAM in lymphatic network formation and function. FASEB J. 2013 Mar;27(3):978-90.
  • Jurisic G*, Maby-El Hajjami H*, Karaman S, Ochsenbein AM, Alitalo A, Siddiqui SS, Ochoa Pereira C, Petrova TV, Detmar M. An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation. Circ Res. 2012 Aug 3;111(4):426-36.
  • Turanli ET, Beger T, Erdincler D, Curgunlu A, Karaman S, Karaca E, Dasdemir S, Bolayirli M, Yazici H. Common MEFV mutations and polymorphisms in an elderly population: an association with E148Q polymorphism and rheumatoid factor levels. Clin Exp Rheumatol. 2009 Mar-Apr;27(2):340-3.
Book chapters
  • Karaman S, Nurmi H, Antila S, Alitalo K. Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. Methods Mol Biol. 2018;1846:291-300. Guillermo Oliver and Mark Kahn (Eds): Lymphangiogenesis September 2018.
  • Karaman S, Aspelund A, Detmar M, Alitalo K. The lymphatic system. European Society of Cardiology (ESC) Textbook of Vascular Biology.