Mattila J, Viitanen A, Fabris G, Strutynska T, Korzelius J, Hietakangas V. Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation. Science Advances, 2024, 10:eadi2671.
Paukštytė J, López Cabezas RM, Feng Y, Tong K, Hanke D, Elomaa E, Gregorova P, Doudin M, Särkkä M, Sarameri J, Lippi A, Vihinen H, Juutila J, Nieminen AI, Törönen P, Holm L, Jokitalo E, Krisko A, Huiskonen J, Sarin P, Hietakangas V, Picotti P, Barral Y, Saarikangas J. Mapping protein structural changes identifies new determinants of aging. Molecular Cell, 2023, 83: 3360-3376.
van den Berg L, Kokki K, Wowro SJ, Petricek KM, Deniz O, Stegmann CA, Robciuc M, Teesalu M, Melvin RG, Nieminen AI, Schupp M, Hietakangas V. Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange. Cell Reports, 2023; 42:112739.
Havula E, Ghazanfar S, Lamichane N, Francis D, Hasygar K, Liu Y, Alton L, Johnstone J, Needham E, Pulpitel T, Clark, T, Nirubini H, Shang V, Tong, V, Jiwnani N, Audia G, Alves A, Sylow L, Mirth C, Neely GG, Yang J, Hietakangas V, Simpson S, Senior A. Genetic variation of macronutrient tolerance in Drosophila melanogaster. Nature Communications, 2022; 13:1637.
Döhla J, Kuuluvainen E, Gebert N, Amaral A, Englund JI, Gopalakrishnan S, Konovalova S, Nieminen AI, Salminen ES, Torregrosa Munumer R, Ahlqvist K, Yang Y, Bui H, Otonkoski T, Käkelä R, Hietakangas V, Tyynismaa H, Ori A, Katajisto P. Metabolic determination of cell fate through selective inheritance of mitochondria. Nature Cell Biology, 2022; 24:148-154.
Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi, Oleg Dyachok M, Montaser H, Lund P-E, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson P-O, Barg S, Tengholm A, Otonkoski T. Functional, metabolic and transcriptional maturation of stem cell derived beta-cells. Nature Biotechnology, 2022, doi: 10.1038/s41587-022-01219-z
Kokki K*, Lamichane N*, Nieminen AI, Ruhanen H, Rovenko B, Havula E, Käkelä R, Hietakangas V. Metabolic gene regulation by Drosophila GATA transcription factor Grain. PLoS Genetics, 2021, doi: 10.1371/journal.pgen.1009855
*Equal contribution
Viitanen A, Gullmets J, Morikka J, Katajisto P, Mattila J, Hietakangas V. An image analysis method for regionally defined cellular phenotyping of the Drosophila midgut. Cell Reports Methods, 2021, doi: 10.1016/j.crmeth.2021.100059.
Hasygar K, Deniz O, Liu Y, Gullmets J, Hynynen R, Ruhanen H, Kokki K, Käkelä R, Hietakangas V. Coordinated control of adiposity and growth by anti-anabolic kinase ERK7. EMBO Reports, 2020, e201949602.
Qiao X, Liu Y, Llamazares Prada M, Haikala H, Talvinen K, Gupta A, Yetukuri L, Pylvänäinen JW, Meinander A, Aittokallio T, Kronqvist P, Klefström J, Hietakangas V, Eilers M, Westermarck J. UBR5 governs MYC protein expression thresholds in development and cancer. Cancer Research, 2020, 80: 1414-1427.
Melvin RG, Lamichane N, Havula E, Kokki K, Soeder C, Jones C, Hietakangas V. Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis. eLife, 2018, 7. pii: e40841.
Mattila J, Kokki K, Hietakangas V, Boutros M. Stem cell intrinsic hexosamine metabolism regulates intestinal adaptation to nutrient content. Developmental Cell, 2018, 47:112-121.
Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, Sundström J, Kauko O, Grénman R, Varjosalo M, Westermarck J, Hietakangas V. PWP1 mediates nutrient-dependent growth control through nucleolar regulation of ribosomal gene expression. Developmental Cell, 2017, 43:240-252.
Teesalu M, Rovenko BM, Hietakangas V. Salt inducible kinase 3 provides sugar tolerance by regulating NADPH/NADP+ redox balance. Current Biology, 2017, 27:458-464.
Mattila J*, Havula E*, Suominen E, Teesalu M, Surakka I, Hynynen R, Kilpinen H, Väänänen J, Hovatta I, Käkelä R, Ripatti S, Sandmann T, Hietakangas V. Mondo-Mlx mediates organismal sugar sensing through Gli-similar transcription factor Sugarbabe. Cell Reports, 2015, 13:350-64.
* Equal contribution
Bartok O*, Teesalu M*, Ashwall-Fluss R, Pandey V, Hanan M, Rovenko B, Poukkula M, Havula E, Moussaieff A, Vodala S, Nahmias Y, Kadener S, Hietakangas V. The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing. EMBO Journal, 2015, 34:1538-53.
* Equal contribution
Hasygar K, Hietakangas V. p53- and ERK7-dependent Ribosome Surveillance Response Regulates Drosophila Insulin-like Peptide Secretion. PLoS Genetics, 2014, 10:e1004764.
Havula E, Teesalu M, Hyötyläinen T, Seppälä H, Hasygar K, Auvinen P, Orešič M, Sandmann T, Hietakangas V. Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. PLoS Genetics, 2013, 9:e1003438.
Deniz O, Hasygar K, Hietakangas V. Emerging cellular and physiological roles of the conserved atypical MAP kinase ERK7. FEBS Letters, 2023; 597:601-607.
Havula E, Hietakangas V. Sugar sensing by ChREBP/Mondo-Mlx – new insight into downstream regulatory networks and integration of nutrient-derived signals. Current Opinion in Cell Biology, 2018, 51:89-96.
Mattila J, Hietakangas V. Regulation of Carbohydrate Energy Metabolism in Drosophila melanogaster. Genetics, 2017, 207:1231-1253.
Havula E, Hietakangas V. Glucose sensing by ChREBP/MondoA-Mlx transcription factors. Seminars in Cell & Developmental Biology, 2012. 23:640-647.