Publications

Selected publications

Original articles

Melvin RG, Lamichane N, Havula E, Kokki K, Soeder C, Jones C, Hietakangas V. Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis. eLife 2018, 7. pii: e40841.

Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, Sundström J, Kauko O, Grénman R, Varjosalo M, Westermarck J, Hietakangas V. PWP1 mediates nutrient-dependent growth control through nucleolar regulation of ribosomal gene expression. Developmental Cell 2017, 43:240-252.

Teesalu M, Rovenko BM, Hietakangas V. Salt inducible kinase 3 provides sugar tolerance by regulating NADPH/NADP+ redox balance. Current Biology 2017, 27:458-464.

Mattila J*, Havula E*, Suominen E, Teesalu M, Surakka I, Hynynen R, Kilpinen H, Väänänen J, Hovatta I, Käkelä R, Ripatti S, Sandmann T, Hietakangas V. Mondo-Mlx mediates organismal sugar sensing through Gli-similar transcription factor Sugarbabe. Cell Reports 2015, 13:350-64.
* Equal contribution

Bartok O*, Teesalu M*, Ashwall-Fluss R, Pandey V, Hanan M, Rovenko B, Poukkula M, Havula E, Moussaieff A, Vodala S, Nahmias Y, Kadener S, Hietakangas V. The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing. EMBO Journal 2015, 34:1538-53.
* Equal contribution

Hasygar K, Hietakangas V. p53- and ERK7-dependent Ribosome Surveillance Response Regulates Drosophila Insulin-like Peptide Secretion. PLoS Genetics 2014, 10:e1004764.

Havula E, Teesalu M, Hyötyläinen T, Seppälä H, Hasygar K, Auvinen P, Orešič M, Sandmann T, Hietakangas V. Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. PLoS Genetics 2013. 9:e1003438.

Review articles

Havula E, Hietakangas V. Sugar sensing by ChREBP/Mondo-Mlx – new insight into downstream regulatory networks and integration of nutrient-derived signals. Current Opinion in Cell Biology 2018, 51:89-96.

Mattila J, Hietakangas V. Regulation of Carbohydrate Energy Metabolism in Drosophila melanogaster. Genetics 2017, 207:1231-1253.

Havula E, Hietakangas V. Glucose sensing by ChREBP/MondoA-Mlx transcription factors. Seminars in Cell & Developmental Biology 2012. 23:640-647.

 

All Publications

Link to PubMed