Publications

Ekaterina Sidorenko, Maria Sokolova, Antti Pennanen, Salla Kyheröinen, Guido Posern, Roland Foisner, Maria K.

Vartiainen. Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity bioRxiv 2021.01.08.425886; doi: https://doi.org/10.1101/2021.01.08.425886

  • Ulferts S, Prajapati B, Grosse R, Vartiainen MK. Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus. Cold Spring Harb Perspect Biol. 2020 Dec 7:a040121. doi: 10.1101/cshperspect.a040121. https://pubmed.ncbi.nlm.nih.gov/33288541/ PDF available at: http://cshperspectives.cshlp.org/cgi/reprint/cshperspect.a040121.pdf?ijkey=9TyazWmdsh3CPPF&keytype=finite

  • Hyrskyluoto A, Vartiainen MK. Regulation of nuclear actin dynamics in development and disease.Curr Opin Cell Biol. 2020 Jun;64:18-24. doi: 10.1016/j.ceb.2020.01.012. https://pubmed.ncbi.nlm.nih.gov/32088545/

  • Redchuk TA, Karasev MM, Verkhusha PV, Donnelly SK, Hülsemann M, Virtanen J, Moore HM, Vartiainen MK, Hodgson L, Verkhusha VV. Optogenetic regulation of endogenous proteins. Nat Commun. 2020 Jan 30;11(1):605. doi: 10.1038/s41467-020-14460-4. https://pubmed.ncbi.nlm.nih.gov/32001718/

  • Kyheröinen S, Vartiainen MK. Nuclear actin dynamics in gene expression and genome organization. Semin Cell Dev Biol. 2019 Nov 14. pii: S1084-9521(18)30314-8. doi:10.1016/j.semcdb.2019.10.012. https://pubmed.ncbi.nlm.nih.gov/31735514/

  • Sidorenko E, Vartiainen MK. Nucleoskeletal regulation of transcription: Actin on MRTF. Exp Biol Med (Maywood). 2019 Nov;244(15):1372-1381. doi: 10.1177/1535370219854669. https://pubmed.ncbi.nlm.nih.gov/31142145/

  • Viita T, Kyheröinen S, Prajapati B, Virtanen J, Varjosalo M, Vartiainen MK. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. J Cell ci 2019 : jcs.226852 doi: 10.1242/jcs.226852 Published 19 March 2019 https://pubmed.ncbi.nlm.nih.gov/30890647/ >See also the First Person interview of Tiina: http://jcs.biologists.org/content/132/8/jcs232520
  • Sokolova M, Moore HM, Prajapati B, Dopie J, Merilainen L, Honkanen M, Matos RC, Poukkula M, Hietakangas V, Vartiainen MK Nuclear actin is required for transcription during Drosophila oogenesis iScience 2018 Nov 30;9:63-70. doi: 10.1016/j.isci.2018.10.010 https://pubmed.ncbi.nlm.nih.gov/30384134/
  • Nevzorov I, Sidorenko E, Wang W, Zhao H, Vartiainen MK. Myosin-1C uses a novel phosphoinositide-dependent pathway for nuclear localization. EMBO Rep. 2018 Feb;19(2):290-304. doi: 10.15252/embr.201744296. PubMed PMID: 29330316; PubMed Central PMCID: PMC5797967. https://pubmed.ncbi.nlm.nih.gov/29330316/
  • Moore HM, Vartiainen MK. F-actin organizes the nucleus. Nat Cell Biol. 2017 Nov 29;19(12):1386-1388. doi: 10.1038/ncb3650. PubMed PMID:29184179 https://pubmed.ncbi.nlm.nih.gov/29184179/
  • Kristó I, Bajusz C, Borsos BN, Pankotai T, Dopie J, Jankovics F, Vartiainen MK, Erdélyi M, Vilmos P. The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export. Biochim Biophys Acta. 2017 Oct;1864(10):1589-1604. doi: 10.1016/j.bbamcr.2017.05.020. PubMed PMID:28554770. https://pubmed.ncbi.nlm.nih.gov/28554770/
  • Virtanen JA, Vartiainen MK. Diverse functions for different forms of nuclear actin. Curr Opin Cell Biol. 2017 Jun;46:33-38. doi: 10.1016/j.ceb.2016.12.004. PubMed PMID:28092729. https://pubmed.ncbi.nlm.nih.gov/28092729/
  • Sharili AS, Kenny FN, Vartiainen MK, Connelly JT. Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes. Sci Rep. 2016 Sep 21;6:33893. doi: 10.1038/srep33893. PubMed PMID: 27650314; PubMed Central PMCID: PMC5030641. https://pubmed.ncbi.nlm.nih.gov/27650314/
  • Viita T, Vartiainen MK. From Cytoskeleton to Gene Expression: Actin in the Nucleus. Handb Exp Pharmacol. 2017;235:311-329. doi: 10.1007/164_2016_27. PubMed PMID:27316910. https://pubmed.ncbi.nlm.nih.gov/27316910/
  • Dopie J, Rajakylä EK, Joensuu MS, Huet G, Ferrantelli E, Xie T, Jäälinoja H, Jokitalo E, Vartiainen MK. Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators. J Cell Sci. 2015 Jul 1;128(13):2388-400. doi:10.1242/jcs.169441. PubMed PMID: 26021350; PubMed Central PMCID: PMC4510847. https://pubmed.ncbi.nlm.nih.gov/26021350/ > Faculty of 1000 recommendation: https://f1000.com/prime/725524420
  • Rajakylä EK, Viita T, Kyheröinen S, Huet G, Treisman R, Vartiainen MK. RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1. Nat Commun. 2015 Jan 14;6:5978. doi: 10.1038/ncomms6978. PubMed PMID: 25585691;PubMed Central PMCID: PMC4309436. https://pubmed.ncbi.nlm.nih.gov/25585691/
  • Ahtiainen L, Lefebvre S, Lindfors PH, Renvoisé E, Shirokova V, Vartiainen MK, Thesleff I, Mikkola ML. Directional cell migration, but not proliferation, drives hair placode morphogenesis. Dev Cell. 2014 Mar 10;28(5):588-602. doi:10.1016/j.devcel.2014.02.003. PubMed PMID:24636260. https://pubmed.ncbi.nlm.nih.gov/24636260/
  • Rajakylä EK, Vartiainen MK. Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression. Small GTPases.2014;5:e27539. doi: 10.4161/sgtp.27539. PubMed PMID:24603113; PubMed Central PMCID: PMC4114923. https://pubmed.ncbi.nlm.nih.gov/24603113/
  • Joensuu M, Belevich I, Rämö O, Nevzorov I, Vihinen H, Puhka M, Witkos TM, Lowe M, Vartiainen MK, Jokitalo E. ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays. Mol Biol Cell. 2014 Apr;25(7):1111-26. doi: 10.1091/mbc.E13-12-0712. PubMed PMID: 24523293; PubMed Central PMCID: PMC3967974. https://pubmed.ncbi.nlm.nih.gov/24523293/
  • Grosse R, Vartiainen MK. To be or not to be assembled: progressing into nuclear actin filaments. Nat Rev Mol Cell Biol. 2013 Nov;14(11):693-7. doi:10.1038/nrm3681. PubMed PMID: 24088744 https://pubmed.ncbi.nlm.nih.gov/24088744/
  • Skarp KP, Vartiainen MK. Actin as a model for the study of nucleocytoplasmic shuttling and nuclear dynamics. Methods Mol Biol. 2013;1042:245-55. doi:10.1007/978-1-62703-526-2_18. PubMed PMID: 23980013. https://pubmed.ncbi.nlm.nih.gov/23980013/
  • Skarp KP, Huet G, Vartiainen MK. Steady-state nuclear actin levels are determined by export competent actin pool.Cytoskeleton (Hoboken). 2013 Oct;70(10):623-34. doi: 10.1002/cm.21116. PubMed PMID:23749625. https://pubmed.ncbi.nlm.nih.gov/23749625/
  • Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J. Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature. 2013 May 23;497(7450):507-11. doi: 10.1038/nature12105. PubMed PMID: 23644458; PubMed Central PMCID: PMC3666313. https://pubmed.ncbi.nlm.nih.gov/23644458/
  • Huet G, Rajakylä EK, Viita T, Skarp KP, Crivaro M, Dopie J, Vartiainen MK. Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool. J Cell Sci. 2013 Jan 15;126(Pt 2):497-507. doi:10.1242/jcs.113241. PubMed PMID: 23203801 https://pubmed.ncbi.nlm.nih.gov/23203801/
  • Huet G, Skarp KP, Vartiainen MK. Nuclear actin levels as an important transcriptional switch. Transcription. 2012 Sep-Oct;3(5):226-30. doi:10.4161/trns.21062. PubMed PMID: 22771994; PubMed Central PMCID:PMC3632617. https://pubmed.ncbi.nlm.nih.gov/22771994/
  • Vartiainen MK. Nucleo-cytoplasmic actin relationships in Stockholm. Nucleus. 2012 Mar 1;3(2):123-5. doi: 10.4161/nucl.19515. PubMed PMID:22555602; PubMed Central PMCID: PMC3383565. https://pubmed.ncbi.nlm.nih.gov/22555602/
  • Dopie J, Skarp KP, Rajakylä EK, Tanhuanpää K, Vartiainen MK. Active maintenance of nuclear actin by importin 9 supports transcription. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):E544-52. doi: 10.1073/pnas.1118880109. PubMed PMID: 22323606; PubMed Central PMCID: PMC3295300. https://pubmed.ncbi.nlm.nih.gov/22323606/
  • Rohn JL, Sims D, Liu T, Fedorova M, Schöck F, Dopie J, Vartiainen MK, Kiger AA, Perrimon N, Baum B. Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol. 2011 Sep 5;194(5):789-805. doi: 10.1083/jcb.201103168. PubMed PMID: 21893601; PubMed Central PMCID: PMC3171124. https://pubmed.ncbi.nlm.nih.gov/21893601/
  • Nevalainen EM, Braun A, Vartiainen MK, Serlachius M, Andersson LC, Moser M, Lappalainen P. Twinfilin-2a is dispensable for mouse development. PLoS One. 2011;6(8):e22894. doi: 10.1371/journal.pone.0022894. PubMed PMID: 21876732; PubMed Central PMCID: PMC3158069. https://pubmed.ncbi.nlm.nih.gov/21876732/
  • McGee KM, Vartiainen MK, Khaw PT, Treisman R, Bailly M. Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis. EMBO Rep. 2011 Sep 1;12(9):963-70. doi: 10.1038/embor.2011.141. PubMed PMID: 21799516; PubMed Central PMCID: PMC3166461. https://pubmed.ncbi.nlm.nih.gov/21799516/
  • Pawłowski R, Rajakylä EK, Vartiainen MK, Treisman R. An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A. EMBO J. 2010 Oct 20;29(20):3448-58. doi: 10.1038/emboj.2010.216. PubMed PMID: 20818336; PubMed Central PMCID: PMC2964165. https://pubmed.ncbi.nlm.nih.gov/20818336/
  • Skarp KP, Vartiainen MK. Actin on DNA-an ancient and dynamic relationship. Cytoskeleton (Hoboken). 2010 Aug;67(8):487-95. doi: 10.1002/cm.20464. PubMed PMID: 20593452 https://pubmed.ncbi.nlm.nih.gov/20593452/
  • Vartiainen MK. Nuclear actin dynamics--from form to function. FEBS Lett. 2008 Jun 18;582(14):2033-40. doi: 10.1016/j.febslet.2008.04.010.PubMed PMID: 18423404. https://pubmed.ncbi.nlm.nih.gov/18423404/
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