Neurotrophic Factors and Regeneration

Our research group is investigating the signalling and biological functions of GDNF neurotrophic family ligands and endoplasmic reticulum located CDNF/MANF protein families, both within and outside of the nervous system. We are also interested in the therapeutic potential of these proteins in various diseases, so we are testing their efficacy in animal models of Parkinson's disease and diabetes mellitus. For therapeutic purposes we are also developing small molecules mimicking the action of GDNF and CDNF/MANF proteins. One of the highlights of our research has been, in 2021, the successful completion of phase I-II clinical trials of CDNF protein that was discovered in our laboratory in Parkinson's disease patients by the Finnish company Herantis Pharma Plc.

News and Research Highlights