Morphogenesis and Cellular Dynamics
In the last several decades work on model organisms has revealed that small numbers of highly conserved signaling molecules are repeatedly utilized in various stages of development across species. Despite the increasing knowledge of the molecular basis of tissue morphogenesis, how the activity of these signaling pathways is translated into changes in cell behavior and how cell shape changes affect developmental signaling remain poorly understood. Since morphogenesis involves dynamic cellular processes, tracking real-time changes in cell shapes must be crucial for further understanding these processes. By using the Drosophila pupal wing, we are interested in elucidating how tissue morphogenesis and dynamic cellular communications are regulated at the subcellular level.
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To elucidate how tissue morphogenesis and signaling molecules are regulated during development, precise spatial and temporal control of...