The gastrointestinal epithelium undergoes rapid and continuous renewal, a process tightly regulated by surrounding stromal cells, such as fibroblasts. Disruption of this regulatory balance contributes to pathologies, such as colorectal cancer, one of the most prevalent and deadly malignancies. In Ollila lab, we investigate the identities and functions of the various fibroblast subtypes within the gastrointestinal tract, and study the molecular mechanisms facilitating the communication between different cell types. In addition, we study the mechanisms of fibroblast rewiring during tumorigenesis, transforming from homeostatic to cancer-promoting cells. Our studies deepen the understanding of stromal-epitelial crosstalk, potentially uncovering novel therapeutic approaches for gastrointestinal pathologies such as colorectal cancer.