Publications, Peer-Reviewed Articles and Book Chapters of the Mitochondrial Morphogenesis research group – Zhao Lab
Peer-Reviewed Articles and Book Chapters

Yang Z, Wang L, Yang C, Pu S, Guo Z, Wu Q, Zhou Z, Zhao H*. Mitochondrial Membrane Remodeling. Front. Bioeng. Biotechnol. 2021, 9, 786806. *Corresponding author.

Hilander T, Jackson CB, Robciuc M, Bashir T and Zhao H*. The roles of assembly factors in mammalian mitoribosome biogenesis. Mitochondrion 2021, 60: 70-84. *Corresponding author

Wang L, Yan Z, Vihinen H, Eriksson O, Wang W, Soliymani R, Lu Y, Xue Y, Jokitalo E, Li J, Zhao H*. FAM92A1 Is a BAR Domain Protein Required for Mitochondrial Ultrastructure and Function. J. Cell Biol. 2019, 218 (1): 97-111.  *Corresponding author

Zhao H*, Lappalainen P. A simple guide to biochemical approaches for analyzing protein-lipid interactions. Mol. Biol. Cell. 2012, 23 (15): 2823-2830. *Corresponding author

Zhao H*, Hakala M, Lappalainen P. ADF/Cofilin Binds Phosphoinositides in a Multivalent Manner to Act as a PIP2-Density Sensor. Biophys. J. 2010, 98 (10): 2327-2336. *Corresponding author

Qian W, Li Q, Wu X, Li W, Li Q, Zhang J, Li M, Zhang D, Zhao H, Zou X, Jia H, Zhang L, Yang XD & Hou Z. Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein. Oncogene 2020, 39: 6802-6815.

Zhu Y, Wang T, He S, Pu S, Zhao H, Zhou Z, Wu Q. Comparison of antiobesity effects of adipose-derived stromal/stem cells from different sources in a natural aging model. Diabetes Metab. Syndr. Obes. 2021, 14: 4535-4546.

Yang C, Pu S, Zhu H, Qin W, Zhao H, Guo Z & Zhou Z. Identification and functional characterization of CD133(+)GFAP(+)CD117(+)Sca1(+) neural stem cells. Mol. Cell Biochem. 2022. (E-pub ahead of print).

Salo, V. T., Li, S., Vihinen, H., Hölttä-Vuori, M., Szkalisity, A., Horvath, P., Belevich, I., Peränen, J., Thiele, C., Somerharju, P., Zhao, H., Santinho, A., Thiam, A. R., Jokitalo, E. & Ikonen, E. Seipin facilitates triglyceride flow to lipid droplet and counteracts droplet ripening via endoplasmic reticulum contact. Dev. Cell 2019, 50 (4): 478-493.

Nevzorov I,  Sidorenko E, Wang W, Zhao H, Vartiainen MK. Myosin-1 C uses a novel phosphoinositide-dependent pathway for nuclear localization. EMBO Rep. 2018, 19 (2): 290-304.

Senju Y, Kalimeri M, Koskela EV, Somerharju P, Zhao H, Vattulainen I, Lappalainen P. Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides. Proc. Natl. Acad. Sci. USA. 2017, 114 (43): E8977-E8986.

Zhang H, Liu D, Wang L, Liu Z, Wu R, Janoniene A, Ma M, Pan G, Baranauskiene L, Zhang L, Cui W, Petrikaite V, Matulis D, Zhao H, Pan J, Santos HA. Microfluidic encapsulation of procky Zinc-doped copper oxide nanoparticles with CD1142 modified spermine acetalated dextran for efficient cancer therapy. Adv. Healthc. Mater. 2017, 6 (11): 2192-2640.

Prevost C., Zhao H, Manzi J, Lemichez  E, Lappalainen  P, Callan-Jones A, Bassereau P. IRSp53 senses negative membrane curvature and phase separates along membrane tubules. Nat. Commun. 2015, 6: 8529.

Ramalingam N, Franke C,  Jaschinski E, Winterhoff M, Lu Y, Brühmann S,  Junemann A, Meier H, Noegel A, Weber I, Zhao H, Merkel R, Schleicher M, Faix J. A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D-confinement.  Nat. Commun. 2015, 6: 8496.

Nguyen SD, Javanainen M, Rissanen S, Zhao H, Huusko J, Kivelä AM, Ylä-Herttuala S,  Navab M, Fogelman AM, Vattulainen I, Kovanen PT, Öörni K. Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDl aggregation. J. Lipid Res. 2015, 56 (6): 1206-1221.

Linkner J, Witte G, Zhao H, Junemann A, Nordholz B, Runge-Wollmann P, Lappalainen P, Faix J. The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and cytokinesis. J. Cell Sci. 2014, 127 (6): 1279-1292.

Zhao H, Michelot A, Koskela EV, Tkach V, Stamou D, Drubin DG, and Lappalainen P. Membrane-sculpting BAR and F-BAR domains generate stable lipid microdomains. Cell Reports 2013, 4 (6): 1213-1223.

Weber M*, Zhao H*, Aro N, Yuan Q, Lappalainen P, and Jäntti J. A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions. Mol. Biol. Cell 2013, 24 (3): 331-341. * equal contribution

Pykalainen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakala J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R, and Lappalainen P. The BAR domain of epithelial-specific protein Pinkbar stabilizes planar membrane sheets. Nat. Struct. Mol. Biol. 2011, 18 (8): 902-907.

Zhao H, Pykalainen A, and Lappalainen P. I-BAR domain proteins: linking actin and membrane dynamics in the formation of plasma membrane protrusions. Curr. Opin. Cell Biol. 2011, 23 (1): 14-21.

Saarikangas J, Zhao H, Lappalainen P. Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides. Physiol. Rev. 2010, 90 (1): 259-289.

Ramalingam N, Zhao H, Breitsprecher D, Lappalainen P, Faix J, and Schleicher M. Phospholipids regulate localization and activity of mDia1 formin. Eur. J. Cell Biol. 2010, 8 (10): 723-732.

Saarikangas J,* Zhao H*, Pykalainen A, Laurinmaki P, Mattila PK, Kinnunen PK, Butcher SJ, Lappalainen P. Molecular mechanisms of membrane deformation by I-BAR domain proteins. Curr. Biol. 2009, 19 (2): 95-107. * equal contribution

Zhao H, Sood R, Jutila A, Shambhunath B, Fimland G, Nissen-Meyer J, and Kinnunen PKJ. Interaction of the antimicrobial peptide pheromone Plantaricin A with model membranes: implications for a novel mechanism of action. Biochim. Biophys. Acta Biomembranes 2006, 1758 (9): 1461-1474.

Zhao H, Arimatti J, Nurminen T, Wickström SA, Jorma KO, and Kinnunen PKJ. Binding of endostatin to phosphatidylserine-containing membranes and formation of amyloid-like fibers. Biochemistry 2005, 44 (8): 2857-2863.

Metso A, Zhao H, Tuunainen I, and Kinnunen PKJ. Observation of the main phase transition of dinervonoylphosphocholine giant liposomes by fluorescence microscopy. Biochim. Biophys. Acta Biomembranes 2005, 1713 (2): 83-91.

Zhao H, Tuominen EKJ, and Kinnunen PKJ. Formation of amyloid fibers triggered by phophatidylserine containing membranes. Biochemistry 2004, 43 (32): 10302-10307.

Zhao H, Shambhunath B, Tuominen EKJ, and Kinnunen PKJ. Binding of Histone H1 to human leukemic T cells and comparison with giant liposomes. Biochemistry 43 (31), 2004, 10192-10202.

Zhao H and Kinnunen PKJ. Modulation of phospholipase A2 activity by antimicrobial peptides. Antimicrob. Agents Chemother. 2003, 47 (3): 965-971.

Zhao H and Kinnunen PKJ (2002) Binding of the antimicrobial peptides temporin L to liposomes assessed by Trp Fluorescence. J. Biol. Chem. 2002, 277 (28): 25170-25177.

Zhao H, Dubielecka PM, Söderlund T, and Kinnunen PKJ. Interaction of adriamycin, cytochrome c, and serum albumin with lipid monolayers containing poly(ethylene glycol)-ceramide. Biophys. J. 2002, 83 (2): 954-967.

Zhao H, Rinaldi CR, Di Giulio A, Simmaco M, and Kinnunen PKJ. Interactions of the antimicrobial peptides temporins with model membranes. Comparison of temporins B and L. Biochemistry 2002. 41 (13): 4425-4436.

Zhao H, Mattila JP, Holopainen JM, Kinnunen PKJ. Comparison of the membrane association of two antimicrobial peptides, magainin 2 and indolicidin. Biophys. J. 2001, 81 (5): 2979-2991.

Nurminen TA, Holopainen JM, Zhao H, and Kinnunen PKJ. Observation of topical catalysis by sphingomyelinase coupled to microspheres. J. Am. Chem. Soc. 2002, 124 (41): 12129-12134.

Rinaldi AC, Mangoni ML, Rufo A, Luzi C, Simmaco M, Barra D, Zhao H, Kinnunen PKJ, Bozzi A, and Di Giulio A. Temporin L: antimicrobial, cytotoxic activities and effects on membrane permeabilization in lipid vesicles. Biochem. J. 2002, 368 (1): 91-100.

Yang H, Li M, Zhang W, Zhao H, and Zhang Z. Characteristics of photosensitization of pheophorbide in liposomal media. Sci. China, Series C: Life Sciences 1999, 42 (5): 471-480.

Xu YM, Zhao H, and Zhang Z. Raman Spectroscopic study of microcosmic photosensitive damage on the liposomes of the mixed phospholipids sensitized by hypocrellin and its derivatives. J. Photochem. Photobiol. B: Biology 1998, 43: 41-46.

Zhang WG, Weng M, Pang SZ, Zhang MH, Yang HY, Zhao H and Zhang Z. A novel photosensitizer, 2-butylamino-2-demethoxy-hypocrellin A (2-BA-2-DMHA) - 1. Synthesis of 2-BA-2-DMHA and its phototoxicity to MGC803 cells. J. Photochem. Photobiol. B: Biology 1998, 44 (1): 21-28.

Zhao H, Xu YM., and Zhang ZY. Raman spectroscopic studies of DNA photodamage sensitized by hypocrellin B and 5-brominated hypocrellin B. Chin. Sci. Bull. 1998, 43 (13): 1128-1134.

Zhang HY, Zhao H, Zhang ZY. Studying dynamic process of photosensitization by ESR method. Sci. China, Series C: Life Sciences. 1997, 40 (4): 356-362.



Yosuke S*, Lappalainen P, Zhao H*. Liposome co-sedimentation and co-flotation assays to study lipid-protein interactions. Methods in Molecular Biology Vol. 2251, Phosphoinositides (978-1-0716-1141-8), chapter 14, Springer, USA, 2021. * Corresponding author

Yosuke S, Zhao H*. Fluorescence assays to study membrane penetration of proteins. Methods in Molecular Biology Vol. 2251, Phosphoinositides (978-1-0716-1141-8), chapter 16, Springer, USA, 2021. * Corresponding author

Lappalainen P, Makkonen M, and Zhao H. Regulation of cytoplasmic actin monomer pool. in Actin-Based Motility, Part 2, 213-235. Springer, USA, 2010.

Zhao H, Rinaldi A C, Rufo A, Bozzi A, Kinnunen PKJ, and Di Giulio A. Structural and charge requirements for antimicrobial peptide insertion into biological and model membranes. In Pore-Forming Peptides and Protein Toxins (Menestrina, G., Dalla Serra, M. and Lazarovici, P., eds.), pp. 151-177, Harwood Academic Publishers, Reading, UK. 2002

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