New article in Stem Cells International
6.4.2022 Members of the Pietiläinen group in collaboration with the Pirinen group published optimised protocols for adipocyte cell culture.
E. Herbers, M. Patrikoski, A. Wagner, R. Jokinen, A. Hassinen, S. Heinonen, S. Miettinen, H. Peltonieni, E. Pirinen, K. Pietiläinen 2022 Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes in Stem Cells International https://doi.org/10.1155/2022/3308194
12.3.2021 Check out our new preprint in Biorxiv:
Nicotinamide riboside alleviates Parkinson’s disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure. Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Nilsen, Jaan-Olle Andressoo, Eija Pirinen. bioRxiv 2021.03.12.435062. DOI: https://doi.org/10.1101/2021.03.12.435062
12/2020 In a Diabetes research foundation's interview series focusing on diabetes research supporters and researchers, Eija Pirinen tells about her background, motivations for obesity research and future goals. Read more at https://www.diabetestutkimus.fi/tukijat_ja_tutkijat_kertovat/eija_pirinen_-_diabetestutkija (only in Finnish)
4.12.2020 -> https://twitter.com/MolMetab/status/1334789249816801282
5.11.2020 "What makes mitochondria lazy?" we wonder in the most recent issue of Yliopisto (8/2020). Eija Pirinen talks about developing a 3D cell culture model for adipose tissue, and how understanding mitochondria is key when studying obesity. Read the 8/2020 issue of Yliopisto magazine at /fi/uutiset/terveys/ihmisen-ylipaino-nakyy-solujen-sisalla-solujen-energiatehtaat-eli-mitokondriot-laiskottelevat
19.8.2020 Pirinen lab collaboration project showing NAD+ depletion in mouse cancer cachexia - read all about it in November's issue of Molecular Metabolism!
J.J. Hulmi, F. Penna, N. Pöllänen, T.A. Nissinen, J. Hentilä, L. Euro, J.H. Lautaoja, R. Ballarò, R. Soliymani, M. Baumann, O. Ritvos, E. Pirinen, M. Lalowski 2020. Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins DOI: 10.1016/j.molmet.2020.101046
14.5.2020 Our niacin trial paper is out! Check out the press release here and be sure to also read the full story in Cell Metabolism: Pirinen et al. 2020 Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy DOI: 10.1016/j.cmet.2020.04.008.
In brief: Pirinen et al. report that niacin, a vitamin B3, can efficiently rescue NAD+ levels in the muscle and blood of patients with mitochondrial myopathy, improving disease signs and muscle strength. NAD+ levels increased also in healthy subjects. The evidence suggests that niacin is an effective NAD+ booster in humans.
30.4.2020 A nice overview of mitochondrial dysfunction in metabolic disease published in the Finnish medical journal Duodecim by Vladimir Heiskanen and Eija Pirinen. Article is in Finnish, abstract available also in English. (Mitokondrioiden toimintahäiriö aineenvaihduntasairauksissa - tulevatko B3-vitamiinit aikanaan avuksi? Duodecim 2020 136(9):1005-12)