This research has mostly been based on associations between microbiota and health. The Human Microbiome (HUMI) research program is addressing translational aspects and is focusing on causal links between microbiota alterations and the increased risk or development of disease, mechanisms of host-microbe interactions, and microbiota-targeted therapeutics and diagnostics. This is realized by 7 Principal Investigators and their teams that collaborate with 9 clinical groups, constituting altogether around 100 researchers and supporting staff.