Publications

SELECTED PUBLICATIONS

Research articles:

This study identifies the transcription factor NF-Y as a key brake on intestinal stem cell proliferation, showing that its loss leads to excessive, nutrient-driven epithelial expansion along with increased mitochondria and lipid droplets in progenitor cells. Mechanistically, NF-Y restrains this growth by regulating transcription of mTORC1 signaling components (including Pras40 and Sestrin), revealing how the intestine calibrates its absorptive capacity to match nutrient availability without overgrowing.

Here we show that Intestinal Stem Cell mTOR signaling acts as an early fate determinant, allowing regional control of intestinal cell differentiation in response to nutrition.

Here, we have developed a powerful tool for organ-wide quantitative analysis of regional heterogeneity in midgut cells.

Here we have cloned a library of 850 Drosophila transcriptional regulators and used it to screen mediators of the Insulin-mTOR network. In case you are interested in using our library for screenings, do not hesitate to contact.

Here we show that intestinal tissue plasticity is dependent on the glucose metabolizing hexosamine synthesis pathway. The work is previewed by .

Reviews:

Full list of publications can be found .