Research articles:

Mattila, J., Viitanen, A., Fabris, G., Korzelius, J & Hietakangas, V. Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation. Science Advances February 9, 2024 vol. 10(6) 

Here we show that Intestinal Stem Cell mTOR signaling acts as an early fate determinant allowing regional control of intestinal cell differentiation in response to nutrition.

Viitanen, A., Gullmets, J., Morikka, J., Katajisto, P., Mattila, J & Hietakangas, V. An image analysis method for regionally defined cellular phenotyping of the Drosophila midgut. Cell Reports Methods July 30, 2021

Here we have developed a powerful tool for organ-wide quantitative analysis of the regional heterogeneity of midgut cells.

Liu, Y., Mattila, J & Hietakangas, V. Systematic Screen for Drosophila Transcriptional Regulators Phosphorylated in Response to Insulin/mTOR Pathway. G3: Genes, Genomes, Genetics August 1, 2020 vol. 10 no. 8:2843-2849

Here we have cloned a library of 850 Drosophila transcriptional regulators and used it to screen mediators of the Insulin-mTOR network. In case you are interested in using our library for screenings, do not hesitate to contact.

Mattila, J., Kokki, K., Hietakangas, V. & Boutros, M. Stem cell intrinsic hexosamine metabolism regulates intestinal adaptation to nutrient content. Dev Cell. 2018 47(1):112-121

Here we show that intestinal tissue plasticity is dependent on the glucose metabolizing hexosamine synthesis pathway. The work is previewed by Beebe & Thummel Dev Cell 2018 47(1).

Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., Kilpinen, H., Väänänen, J., Hovatta, I., Käkelä, R., Ripatti, S., Sandmann, T. & Hietakangas, V. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Rep. 2015 Oct 13;13(2):350-64

Mattila, J., Kallijärvi, J. & Puig, O.: RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc Natl Acad Sci USA 2008 105(39):14873-8

Mattila, J., Omelyanchuk, L., Kyttälä, S., Turunen, H. & Nokkala, S.: Role of Jun N-terminal Kinase (JNK) signaling in the wound healing and regeneration of Drosophila melanogaster wing imaginal disc. Int J Dev Biol 2004 49: 391-399


Mattila & Hietakangas, V.: FlyBook: Regulation of carbohydrate energy metabolism in Drosophila melanogaster. Genetics 2017 207(4) 1231:1253

Puig, O. & Mattila, J.: Understanding Forkhead box class O function: lessons from Drosophila melanogaster. Antioxid Redox Signal 2011 14(4): 635-647

Full list of publications can be found here.