Publications
Selected publications of the PI
- Tuovinen, E. A., Grönholm, J., Öhman, T., Pöysti, S., Toivonen, R., Kreutzman, A., Heiskanen, K., Trotta, L., Toiviainen-Salo, S., Routes, J. M., Verbsky, J., Mustjoki, S., Saarela, J., Kere, J., Varjosalo, M., Hänninen, A. & Seppänen, M. R. J., Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency. J Clin Immunol. 19 Feb 2020.
- Majri S, Fritz JM, Villarino AJ, Zheng L, Kanellopoulou C, Chaigne-Delalande B, Grönholm J, Niemela JE, Afzali B, Biancalana M, Pittaluga S, Sun A, Cohen JL, Holland SM, O’Shea JJ, Uzel G, Lenardo MJ. STAT5B: a differential regulator of the life and death of CD4+ effector memory T cells. J. Immunol. 1:110-118 (2018).
- Afzali B*, Grönholm J*, Vandrovcova J*, O'Brien C, Sun HW, Vanderleyden I, Davis FP, Khoder A, Zhang Y, Hegazy AN, Villarino AV, Palmer IW, Kaufman J, Watts NR, Kazemian M, Kamenyeva O, Keith J, Sayed A, Kasperaviciute D, Mueller M, Hughes JD, Fuss IJ, Sadiyah MF, Montgomery-Recht K, McElwee J, Restifo NP, Strober W, Linterman MA, Wingfield PT, Uhlig HH, Roychoudhuri R, Aitman TJ, Kelleher P, Lenardo MJ, O'Shea JJ, Cooper N, Laurence ADJ. BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency. Nat Immunol. 18:813-823 (2017) *Equal contribution
- Grönholm J, Pagni PP, Pham MN, Gibson CB, Macomber PF, Vela JL, von Herrath M, Lenardo MJ. Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice. Diabetologia. 60:1475-1482 (2017)
- Grönholm J, Lenardo MJ. Novel diagnostic and therapeutic approaches for autoimmune diabetes–a prime time to treat insulitis as a disease. Clin Immunol. 156:109-18 (2015)
- Grönholm J*, Vanhatupa S*, Ungureanu D*, Väliaho J, Laitinen T, Valjakka J and Silvennoinen O. Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1. BMC Biochemistry. 13:20 (2012) *Equal contribution
- Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O and Rämet M. Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. FASEB J. 26:1239-50 (2012)