The recent recognition of the human microbiome as a new emerging hallmark of cancer reflects the importance and immense potential of this rapidly evolving field of cancer research.
In our lab, we delve into the intricate mechanisms of head and neck carcinogenesis, focusing on the dynamic interplay between tumor cells and oral microbiota—particularly, but not exclusively, bacteria. Our research bridges the fields of microbiology, immunology, and oncology within dental science, fostering interdisciplinary collaboration. Such integration is essential for comprehensive approaches to complex diseases like head and neck cancers.
Our discoveries have already made significant waves, unveiling novel mechanisms behind cancer cell phenotypic plasticity, potentially driving lymphatic metastasis. With a network of effective international collaborations as well as the valuable support of our funders, we continue to push the boundaries of knowledge, including how certain bacterial vesicles and toxins can alter the course of cancer development, from potentially premalignant changes to invasive lesions.
For more information, feel free to contact the PI at: abdelhakim.salem@helsinki.fi