Development and diversity of neurons in the dorsal raphe

The dorsal raphe contains diverse neurons, including serotonergic, glutamatergic and GABA neurons, important for regulation of mood and motivation. We are interested in the properties of these cell types and the mechanisms driving their differentiation. In particular, we are interested in the mechanisms by which transcription factors expressed in the post-mitotic neurons drive differentiation of molecularly, anatomically and functionally distinct subsets of dorsal raphe serotonergic neurons.



Haugas M, Tikker L, Achim K, Salminen M, Partanen J. Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. Development  143:  4495-4508;  doi: 10.1242/dev.136614, 2016