GABA neurons are the main inhibitory neurons in the brain, including the brainstem. Functionally diverse and highly important GABA neurons are located in the brainstem, both within and outside the dopaminergic and serotonergic nuclei. However, the spectrum of their subtypes and their specific molecular characteristics are poorly understood.
Our studies have revealed developmental mechanisms and molecular characteristics of the main GABA neuron subgroups in the brainstem. These include GABA neurons associated with the dopaminergic nuclei. Further work should address their cellular diversity, subtype-specific developmental regulatory mechanisms and neurophysiological roles.
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