The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.
Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T.
Nat Commun. 2022 Oct 26;13(1):6363. doi: 10.1038/s41467-022-34069-z.
Cellular shape reinforces niche to stem cell signaling in the small intestine.
Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P.
Sci Adv. 2022 Oct 14;8(41):eabm1847. doi: 10.1126/sciadv.abm1847.
Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle.
Neupane N, Rajendran J, Kvist J, Harjuhaahto S, Hu B, Kinnunen V, Yang Y, Nieminen AI, Tyynismaa H.
Commun Biol. 2022 Oct 5;5(1):1060. doi: 10.1038/s42003-022-04034-z.
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
Nat Biotechnol. 2022 Mar 3. doi: 10.1038/s41587-022-01219-z.
Metabolic determination of cell fate through selective inheritance of mitochondria.
Döhla J, Kuuluvainen E, Gebert N, Amaral A, Englund JI, Gopalakrishnan S, Konovalova S, Nieminen AI, Salminen ES,
Torregrosa Muñumer R, Ahlqvist K, Yang Y, Bui H, Otonkoski T, Käkelä R, Hietakangas V, Tyynismaa H, Ori A, Katajisto P.
Nat Cell Biol. 2022 Feb;24(2):148-154. doi: 10.1038/s41556-021-00837-0.
Threshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism.
Kenvin S, Torregrosa-Muñumer R, Reidelbach M, Pennonen J, Turkia JJ, Rannila E, Kvist J, Sainio MT, Huber N, Herukka SK, Haapasalo A, Auranen M, Trokovic R, Sharma V, Ylikallio E, Tyynismaa H.
Hum Mol Genet. 2021 Oct 12:ddab299. doi: 10.1093/hmg/ddab299.
Metabolic gene regulation by Drosophila GATA transcription factor Grain.
Kokki K, Lamichane N, Nieminen AI, Ruhanen H, Morikka J, Robciuc M, Rovenko BM, Havula E, Käkelä R, Hietakangas V.
PLoS Genet. 2021 Oct 11;17(10):e1009855. doi: 10.1371/journal.pgen.1009855.
An image analysis method for regionally defined cellular phenotyping of the Drosophila midgut.
Viitanen A, Gullmets J, Morikka J, Katajisto P, Mattila J, Hietakangas V.
Cell Rep Methods. 2021 Jul 30;1(5):100059. doi: 10.1016/j.crmeth.2021.100059.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ.
Nature. 2021 Jun;594(7863):430-435. doi: 10.1038/s41586-021-03525-z.
SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism.
Lithovius V, Saarimäki-Vire J, Balboa D, Ibrahim H, Montaser H, Barsby T, Otonkoski T.
Diabetologia. 2021 Mar;64(3):630-640. doi: 10.1007/s00125-020-05346-7.
Coordinated control of adiposity and growth by anti-anabolic kinase ERK7.
Hasygar K, Deniz O, Liu Y, Gullmets J, Hynynen R, Ruhanen H, Kokki K, Käkelä R, Hietakangas V.
EMBO Rep. 2021 Feb 3;22(2):e49602. doi: 10.15252/embr.201949602.
ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons.
Harjuhaahto S, Rasila TS, Molchanova SM, Woldegebriel R, Kvist J, Konovalova S, Sainio MT, Pennonen J, Torregrosa-Muñumer R, Ibrahim H, Otonkoski T, Taira T, Ylikallio E, Tyynismaa H.
Neurobiol Dis. 2020 May 11;141:104940. doi: 10.1016/j.nbd.2020.104940.
Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content.
Woldegebriel R, Kvist J, Andersson N, Õunap K, Reinson K, Wojcik MH, Bijlsma EK, Hoffer MJV, Ryan MM, Stark Z, Walsh M, Cuppen I, van den Boogaard MH, Bharucha-Goebel D, Donkervoort S, Winchester S, Zori R, Bönnemann CG, Maroofian R, O'Connor E, Houlden H, Zhao F, Carpén O, White M, Sreedharan J, Stewart M, Ylikallio E, Tyynismaa H.
Hum Mol Genet. 2020 Jun 3;29(9):1426-1439. doi: 10.1093/hmg/ddaa051.
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P.
Nature. 2019 Jul;571(7765):398-402. doi: 10.1038/s41586-019-1383-0.
Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis.
Melvin RG, Lamichane N, Havula E, Kokki K, Soeder C, Jones CD, Hietakangas V.
Elife. 2018 Nov 27;7. pii: e40841. doi: 10.7554/eLife.40841.
Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
Balboa D, Saarimäki-Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, Eurola S, Ustinov J, Grym H, Huopio H, Partanen J, Wartiovaara K, Otonkoski T.
Elife. 2018 Nov 9;7. pii: e38519. doi: 10.7554/eLife.38519.
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