PUBLICATIONS

Selected publications

 

ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons.
Harjuhaahto S, Rasila TS, Molchanova SM, Woldegebriel R, Kvist J, Konovalova S, Sainio MT, Pennonen J, Torregrosa-Muñumer R, Ibrahim H, Otonkoski T, Taira T, Ylikallio E, Tyynismaa H.
Neurobiol Dis. 2020 May 11;141:104940. doi: 10.1016/j.nbd.2020.104940.

Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content.
Woldegebriel R, Kvist J, Andersson N, Õunap K, Reinson K, Wojcik MH, Bijlsma EK, Hoffer MJV, Ryan MM, Stark Z, Walsh M, Cuppen I, van den Boogaard MH, Bharucha-Goebel D, Donkervoort S, Winchester S, Zori R, Bönnemann CG, Maroofian R, O'Connor E, Houlden H, Zhao F, Carpén O, White M, Sreedharan J, Stewart M, Ylikallio E, Tyynismaa H.
Hum Mol Genet. 2020 Jun 3;29(9):1426-1439. doi: 10.1093/hmg/ddaa051.

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajärvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietiläinen K, Auvinen P, Ristimäki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz ÖH, Katajisto P.
Nature. 2019 Jul;571(7765):398-402. doi: 10.1038/s41586-019-1383-0.

Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis.
Melvin RG, Lamichane N, Havula E, Kokki K, Soeder C, Jones CD, Hietakangas V.
Elife. 2018 Nov 27;7. pii: e40841. doi: 10.7554/eLife.40841.

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
Balboa D, Saarimäki-Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, Eurola S, Ustinov J, Grym H, Huopio H, Partanen J, Wartiovaara K, Otonkoski T.
Elife. 2018 Nov 9;7. pii: e38519. doi: 10.7554/eLife.38519.

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone.
Konovalova S, Liu X, Manjunath P, Baral S, Neupane N, Hilander T, Yang Y, Balboa D, Terzioglu M, Euro L, Varjosalo M, Tyynismaa H.
Redox Biol. 2018 Aug 4;19:37-45. doi: 10.1016/j.redox.2018.07.024.

MANF protects human pancreatic beta cells against stress-induced cell death.
Hakonen E, Chandra V, Fogarty CL, Yu NY, Ustinov J, Katayama S, Galli E, Danilova T, Lindholm P, Vartiainen A, Einarsdottir E, Krjutškov K, Kere J, Saarma M, Lindahl M, Otonkoski T.
Diabetologia. 2018 Oct;61(10):2202-2214. doi: 10.1007/s00125-018-4687-y.

Human pluripotent reprogramming with CRISPR activators.
Weltner J, Balboa D, Katayama S, Bespalov M, Krjutškov K, Jouhilahti EM, Trokovic R, Kere J, Otonkoski T.
Nat Commun. 2018 Jul 6;9(1):2643. doi: 10.1038/s41467-018-05067-x.

Absence of NEFL in patient-specific neurons in early-onset Charcot-Marie-Tooth neuropathy.
Sainio MT, Ylikallio E, Mäenpää L, Lahtela J, Mattila P, Auranen M, Palmio J, Tyynismaa H.
Neurol Genet. 2018 Jun 5;4(3):e244. doi: 10.1212/NXG.0000000000000244.

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.
Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, Deshpande V, Carmeliet P, Katajisto P, Sabatini DM, Yilmaz ÖH.
Cell Stem Cell. 2018 May 3;22(5):769-778.e4. doi: 10.1016/j.stem.2018.04.001.

PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression.
Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, Sundström J, Kauko O, Grénman R, Varjosalo M, Westermarck J, Hietakangas V.
Dev Cell. 2017 Oct 23;43(2):240-252.e5. doi: 10.1016/j.devcel.2017.09.022.

Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9.
Balboa D, Weltner J, Novik Y, Eurola S, Wartiovaara K, Otonkoski T.
Stem Cell Res. 2017 Jul;22:16-19. doi: 10.1016/j.scr.2017.05.005.

Salt-Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH/NADP+ Redox Balance.
Teesalu M, Rovenko BM, Hietakangas V.
Curr Biol. 2017 Feb 6;27(3):458-464. doi: 10.1016/j.cub.2016.12.032.

Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.
Mattila J, Havula E, Suominen E, Teesalu M, Surakka I, Hynynen R, Kilpinen H, Väänänen J, Hovatta I, Käkelä R, Ripatti S, Sandmann T, Hietakangas V.
Cell Rep. 2015 Oct 13;13(2):350-64. doi: 10.1016/j.celrep.2015.08.081.

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.
Katajisto P, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM.
Science. 2015 Apr 17;348(6232):340-3. doi: 10.1126/science.1260384.

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM.
Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163.

All Publications

Link to PubMed