Cell Shape and Motility

How cells changing their shape or moving orchestrate their cytoskeleton?

Cells and tissues are not static structures, but during development they change their size and shape and migrate. Plasticity of cells and tissues also requires remodeling of cytoskeleton in order to orchestrate their adhesive, protrusive and contractile properties. We want to understand how disassembly of actin cytoskeleton is regulated in cells that are changing their shape or moving.