Selected Publications:

Ollila S, Domènech-Moreno E, Laajanen K, Wong IP, Tripathi S, Pentinmikko N, Gao Y, Yan Y, Niemelä EH, Wang TC, Viollet B, Leone G, Katajisto P, Vaahtomeri K, Mäkelä TP.

"Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway". J Clin Invest. 2018 Jan 2;128(1):402-414.

  • Vaahtomeri K., Karaman S., Mäkinen T., Alitalo K. “Lymphangiogenesis guidance by paracrine and pericellular factors”. Genes & Development. 2017 Aug 15;31:1615-34
  • Vaahtomeri K.#, Hauschild R., Brown M., Leithner A., Mehling M., De Vries I., Kaufman W.A., Sixt M#. “Locally triggered release of chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia”. Cell Reports. 2017 May 2; 19(5);902-909. Selected as an issue highlight.
  • Schwarz J., Bierbaum V., Vaahtomeri K., Hauschild R., Brown M., de Vries I., Leithner A., Reversat A., Merrin J., Tarrant T., Bollenbach T., Sixt M. “Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6.” Current Biology. 2017 May 8;27(9):1314-1325.
  • Russo E.*, Teijeira A.*, Vaahtomeri K., Willrodt A-H., Bloch J.S., Nitschké M., Santambrogio L., Kerjaschki D., Sixt M. and Halin C.. ”CCL21 promotes tissue egress of intralymphatic dendritic cells through afferent lymphatic vessels”. Cell Reports. 2016 Feb 23; 14(7):1723-34
  • Yan Y., Ollila S., Wong I., Vallenius T., Palvimo J., Vaahtomeri K., Makela TP. “Sumoylation of AMPKalfa1 by PIAS4 antagonizes the inhibition of mTORC1 signaling by energy stress”. Nature communications. 2015 Nov 30;6:8979
  • Vaahtomeri K. and Sixt M. “Relax and come in”. Nature. 2014 Oct 23;514(7523):441-2
  • Vaahtomeri K. and Mäkelä TP. “Molecular mechanisms of tumor suppression by LKB1”. FEBS letters 2011 Apr 6;585(7):944-51
  • Vallenius T.*, Vaahtomeri K.*, Kovac B., Osiceanu A-M., Viljanen M., and Mäkelä T.P.. “An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers”. Journal of Cell Science. 2011 Feb 1;124(Pt 3):384-93
  • Vaahtomeri K., Ventelä E., Laajanen K., Katajisto P., Wipff PJ, Hinz B., Vallenius T., Tiainen M., Mäkelä TP. “LKB1 is required for TGFbeta mediated myofibroblast differentiation”. Journal of Cell Science, 2008 Nov 1;121(Pt 21):3531-40.
  • Londesborough A., Vaahtomeri K.*, Tiainen M.*, Katajisto P., Ekman N., Vallenius T., Mäkelä T.P. “LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment”. Development, 2008 Jul;135(13):2331-8.
  • Katajisto P., Vaahtomeri K., Ekman N., Ventelä E., Ristimäki A., Feil R., DePinho RA. and Mäkelä TP. “LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis”. Nature Genetics, 2008 Apr;40(4):455-9.
  • Tiainen, M., Vaahtomeri, K., Ylikorkala, A., and Makela, T.P. “Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1)”. Human Molecular Genetics. 2002 Jun 11:1497-1504.