Adipose tissue dysfunction is a central contributor to metabolic disease in obesity and type 2 diabetes.
Our translational research group studies the mechanisms that regulate metabolic flexibility and mitochondrial function in human adipose and other peripheral metabolic tissues, with the goal of understanding how these processes influence long-term metabolic health and insulin sensitivity.
We investigate molecular and cellular pathways that shape tissue mitochondrial function, inflammatory responses, and remodeling, as well as how signals derived from adipose tissue contribute to other organs and systemic metabolic regulation. To address these questions, we integrate human clinical phenotyping and multi-omics data with mechanistic studies in vitro and ex vivo, enabling direct translational insight.
One current area of interest in our group is the role of gut-derived hormones, bile acids and metabolites, which are increasingly recognized as important mediators of the metabolic improvements observed after bariatric surgery. By studying how these signals interact with adipose and muscle tissue and other metabolic organs, we aim to gain insight into pathways that are disrupted in obesity and improved by surgical or pharmacological interventions.