FIBRE-MATCH concept and key research activities in each work package.
Lead Partner: University of Helsinki
WP leader: Anne Salonen
Contact Details: anne.salonen@helsinki.fi
Objectives: The aim is to identify metagenome-based gut microbiome types differing in their inferred capacity to metabolise common dietary fibres and the resultant gas. Further, we aim to characterise metagenomic features of the gut microbiome that associate with gas-related gastrointestinal symptoms in healthy subjects and irritable bowel syndrome (IBS) patients. The project utilizes existing stool metagenome data from the partners and from the public domain.
Lead Partner: Technical University of Tallinn
WP leader: Kaarel Adamberg
Contact Details: kaarel.adamberg@taltech.ee
Objectives: To identify dietary fibre-related microbial metabolic phenotypes of the human gut microbiota by characterizing the key metabolite outputs from common dietary fibres by representative functional gut microbiome types from WP1 in in vitro screening.
Lead Partner: University of Helsinki
WP leader: Anne-Maria Pajari
Contact Details: anne-maria.pajari@helsinki.fi
Objectives: To develop, based on the results of WP1 and WP2, a tailored intervention strategy with fermented fibre-rich food prototype product. WP2 will also develop a database on the contents of different dietary fibres in foods to facilitate analysis of food consumption data from the gut microbiota perspective and specific dietary recommendations for fibre.
Lead Partner: Örebro University
WP leader: Robert Jan Brummer
Contact Details: robert.brummer@oru.se
Objectives: To conduct two PoC trials, one in healthy volunteers and one in IBS patients, to test whether consumption of a microbiome-tailored dietary fibre decreases gas-related digestive symptoms in comparison to an unmatched fibre and/or enhances the health effects associated with fibre consumption. We will also study whether tailored nutritional advice, specifically focusing on fibre type, increases adherence to dietary guidelines, i.e., increases the intake of dietary fibre in habitual diet.