The 7th ScanPath Meeting

Monday, 30 October 2023

08:30-09:30     Registration and light breakfast

09:30-09:40     Welcome and Introduction

09:45-10:15     Key note: Olli Kallioniemi: Data- and AI-driven life science: Foundational models and hallmarks for cancer


                          Session 1: Spatial profiling (Chair: Teijo Pellinen)

10:15-10:45       Antti Kiviaho: An integrative analysis approach to spatial transcriptomics of prostate tumors

10:45-11:00       Andrew Erickson: Spatial genomics prostate cancer

11:00-11:15       Anna Laury: Spatial profiling of Ovarian carcinoma

11:15-11:30       Company presentation: Akoya Biosciences


11:30-12:30       LUNCH


                          Session 2: AI pathology (Chair: Patrick Micke)

12:45-13:00       Pekka Ruusuvuori: Generalization gap in histopathology AI

13:00-13:15       Sampsa Hautaniemi: Instance and semantic segmentation of H&E images in ovarian cancer

13:15-13:30       Tuomas Mirtti: Controllable and explainable AI in clinical pathology

13:30-13:45       Mikko Purhonen: Prediction of Treatment-free Remission with Convolutional Neural Network-guided Image Analysis in CML

13:45-14:00       Company presentation: Miltenyi Biotech

14:00-14:10       Company presentation: Aiforia


14:15-15:15       COFFEE & POSTERS (Kullager)


                          Session 3: Heterogeneity (Chair: Olli Carpén)

15:15-15:30       Steve Bova: Pilot 3D prostate cancer metastatic and nonmetastatic subclone tracking and timing

15:30-15:45       Rolf Skotheim: Challenges and opportunities in managing the extensive heterogeneity of multifocal prostate cancer

15:45-16:00       Martin Johansson: Kidney disease and regeneration

16:00-16:15       Pekka Taimen: Steroid hormone landscape of bladder cancer

16:15-16:25       Company presentation: Standard Biotools, David Guet


16:30-18:00      POSTERS and REFRESHMENTS (Kullager)

18:00-19:30      Activities (Jogging/Gym/Art exhibition/Sauna+pool)

19:30                SPARKLING

20:00                DINNER



Tuesday, 31 October 2023

08:30-09:00       Coffee    

                          Session 4: Tumor microenvironment (Chair: Caj Haglund)

09:00-09:15       Linglong Huang: Novel colon cancer multi-marker-defined fibroblast subsets;  associations with micro-niches and survival

09:15-0930        Maria Ulvmar: Analysis of structural vascular and stromal changes in tumor draining lymph nodes

09:30-09:45       Jaakko Knuutila: CAFs in squamous cell carcinoma of the skin

09:45-10:00       Sanna Pasonen-Seppänen: Dynamic interplay between macrophages and melanoma cells in tumor microenvironment

10:00-10:15       Karolina Punovuori: Role of tissue architecture and cell communication in cancer progression

10:15-10:30       Lassi Paavolainen: Unsupervised multiplexed spatial profiling of CAFs

10:30-11:00       COFFEE & CROSSTALK


                          Session 5: Biomarkers (Chair: Arne Östman)

11:00-11:15       Patrick Micke: Novel strategies to understand cancer immunity and its therapeutic impact

11:15-11:30       Caroline Schagerholm: Gene expression profiles in endocrine-resistant breast cancer

11:30-11:45       Camilla Böckelman: Molecular subtypes in gastrointestinal cancers

11:45-12:00       Kari Alitalo: A proxy for stem cells and tumor progression in colorectal cancer

12:00-12:15       Sami Ventelä: Biomarker for identification of HNSCC patients in risk of developing metastastic disease


12:15-13:30       LUNCH (CHECK-OUT TIME IS 12:00)


                           Session 6: Functional models and perturbation (Chair: Carina Strell)

13:30-13:45       Xinsong Chen: Breast Cancer Precision Medicine Assisted by Functional Assays And Multi-omics Data

13:45-14:00       Ashwini Nagaraj: Precision oncology for ovarian cancer using patient-derived immunocompetent cultures

14:00-14:15       Kirsi Ketola: Overcoming drug resistance in prostate cancer

14:15-14:30       Margarita Espona-Fiedler: From drug discovery to Onco-fibrotherapy

14:30-14:45       Heidi Haikala: Modeling solid tumor complexity and vascularity using organ-on-a-chip

14:45-15:00       Vesa Rahkama: High Fidelity Physiological Culture System for Prostate Cancer


15:00-15:15      Closing remarks

Name Title
1. Pauliina Munne Patient Derived Explant Cultures (PDEC) as a Model for Treatment Resistant ERα Positive Breast Cancer
2. Oxana Denisova Protein phosphatase PP2A-based triple-strike therapy for medulloblastoma
3. Rasmus Humlevik Hypoxia and immune evasion in young women with breast cancer: a population-based study
4. Viktor Ljungström Single-cell gene expression analysis of normal tissues for discovery of mechanisms of permissiveness for KRAS mutations
5. Laura Sysivirta Spatial Concordance Between Genome and Proteome in Oncology: A Systematic Review
6. Reetta Nätkin Phenotypic and genotypic characterisation of bicalutamide and enzalutamide resistance in castration-resistant prostate cancer cells
7. Silje Kjølle Basal-like breast cancer secretomes induce angiogenic signaling in the tumor microenvironment
8. Anna Gerdtsson Spatial tumor-immune protein signatures across subtypes of ovarian carcinoma
9. Jenni Säilä FAP/αSMA association with tumor MRI-visibility and progression in prostate cancer
10. Jussi Kasurinen Phenotypic subtypes predict outcomes in colorectal cancer
11. Carina Strell Effect of beta-blockers in patients with ductal carcinoma in situ on the risk of invasive breast cancer recurrence: a retrospective cohort study
12. Ella Kesti The prognostic significance of collagen VI in pancreatic ductal adenocarcinoma
13. Jefim Brodkin Prognostic effect of immunohistochemically classified molecular subtypes in gastric cancer
14. Sonja Koivukoski Unstained tissue imaging and virtual HE-staining of histological whole slide images: an assessment of histological feasibility
15. Margarita Espona-Fiedler High throughput screen in a pancreatic tumor-stroma model: uncovering therapeutic strategies
16. Linglong Huang Identification of spatially localized and prognosis-associated multi-marker-defined mesenchymal cell subsets of human colon cancer
17. Annabrita Schoonenberg FIMM Digital Microscopy and Molecular Pathology Unit
18. Anette Holmström Spatial transcriptomics services in FIMM Single-Cell Analytics Unit
19. Teijo Pellinen Spatial profiling of inflamed clear-cell renal cell carcinoma tumor microenvironment
20. Astrid Murumägi Targeting interacting pathways between cancer cells and fibroblasts in prostate cancer
21. Vesa Rahkama High Fidelity Physiological Culture System for Prostate Cancer
22. Katja-Rikka Louhi SignalStar™ multiplex immunohistochemistry is a flexible technology with fully validated protocols
23. Amanda Lindberg Investigation of PD1-PDL1 interaction as a predictor for response to immune checkpoint therapy in NSCLC patients
24. Hui Yu FGFR2 splice variant as a cell fate adjudicator determines clinical outcomes in NSCLC
25. Artemis Filippou Liprin-a1 contributes to oncogenic MAPK signaling and associates with MEK/ERK inhibitor response
26. Maria Ulvmar Evaluation of vascular and stromal changes in tumor draining lymph nodes of patients with pancreatic cancer using AI-driven image analysis - new potential sources of biomarkers in cancer
27. Robert Stad Akoya Biosciences