The Fagerholm group at the Faculty of Bio- and Environmental Sciences, University of Helsinki is seeking to recruit a

POSTDOCTORAL RESEARCHER

The position is available from 1st September 2018 for minimum of one year with the possibility of extension.

The postdoc will participate in an Academy of Finland-funded project which investigates the molecular mechanisms by which integrins regulate immune cell programming and immune cell-mediated tumor rejection.

The Fagerholm group consists of Immunologists and Biochemists working together to understand the molecular mechanisms which regulate immune cell trafficking and function in vivo. We are especially interested in the role of integrins in immune system regulation and in immune-system related diseases such as immunodeficiency and cancer. We use a wide range of techniques such as mouse genetics, tumor models, in vivo immune cell migration and other functional assays, flow cytometry, cell biology, imaging and next generation sequencing to understand the molecular mechanisms involved in the regulation of immune cell function.

Applicants should possess a PhD degree in a relevant field (or be about to graduate) and an excellent academic record. They should have a strong understanding of basic principles of in vivo immunology and/or transcriptomics/genomics/epigenetics/cell biology, and have the ability to work productively both independently and as part of a team. Experience of techniques such as ChIP-seq and ATAC-seq is considered an advantage.

The salary of the successful candidate will be based on level 5 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance. The starting salary will be ca. 3100 - 3500 euros/month, depending on the appointee’s qualifications and experience. A six-month trial period will be applied.

Application should include the following documents as a single pdf file: a brief statement of research interests, a CV and the names and contact details of 2 referees.

Informal enquiries should be sent to susanna.fagerholm(at)helsinki.fi.
Deadline for application is 31st July 2018, but review of applications will begin immediately and continue until the position is filled.

For an outline of the group’s research: https://www.helsinki.fi/en/researchgroups/integrins-in-immunity.
Technical support for using the recruitment system: rekrytointi(at)helsinki.fi.

Recent publications from the lab include:
1. Savinko T, Guenther C, Uotila LM, Llort Asens M, Yao S, Tojkander S, Fagerholm SC. 2018. Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking. J Immunol 200:3109-3116.
2. Savinko T, Morrison V, Uotila L, Wolff H, Alenius H, Fagerholm SC. 2015. Functional beta2-integrins restrict skin inflammation in vivo, J Invest Dermatol.135:2249.
3. Morrison VL, James MJ, Grzes K, Cook P, Glass DG, Savinko T, Lek HS, Gawden-Bone C, Watts C, Millington OR, MacDonald AS, Fagerholm SC. 2014. Loss of beta2-integrin-mediated cytoskeletal linkage reprograms dendritic cells to a mature migratory phenotype. Nat Commun. 5: 5359.
4. Morrison VL, Macpherson M, Savinko T, Lek HS, Prescott A, Fagerholm SC. 2013. The beta2-integrin-kindlin-3 is essential for T cell homing but dispensable for T cell activation in vivo. Blood, 122:1428.

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31.07.2018 23:59 EEST