The University of Helsinki is a leading Nordic university with a preeminent role in life science research. Within the university, Helsinki Institute of Life Science (HiLIFE) builds on existing strengths, new recruits, and partnerships in order to create an attractive international environment for solving grand challenges in health, food, and environment. It coordinates research infrastructures, provides research-based interdisciplinary training, and supports researchers within its units and partner faculties.

The Laboratory of Structural Biology at HiLIFE is inviting applications for a


In this position you will apply cryo-EM on challenging complexes involved in maintaining protein homeostasis in the cell using novel methodologies for sample preparation. HiLIFE offers an international, supportive, and well-equipped research environment. Further experience can be gained through a six month research visit to University of Oxford.

We welcome applications from candidates at different career levels and with different backgrounds. Prior practical expertise in cryo-EM is desirable but not required. The position is made for four years and is available immediately.

Our research is aimed at understanding the structure and function of biological macromolecules and their complexes. We apply a range of methods, including cryo-EM, advanced fluorescence microscopy methods, and correlative imaging. We are also active in computational method development for these tasks.

In this project you will join a “Structures of Endogenous Macromolecular Assemblies“ consortium formed between three groups in Helsinki and two collaborating groups at the University of Oxford, providing complementary expertise in materials science, CRISPR genome editing, proteostasis, bioengineering, and cryo-EM. Your aim will be to characterize structures of endogenous macromolecular complexes including those involved in proteostasis using a novel type cryo-EM grid that is being developed.

The local cryo-EM core facility houses a Talos Arctica with a Falcon III detector and a Volta phase plate, in addition to a Linkam/Zeiss setup for correlative imaging. Access to several other high-end microscopes, including a Titan Krios, is available for the project through research visits to the University of Oxford.

To apply, please submit your application using the University of Helsinki electronic recruitment system by clicking on Apply for job by August 5, 2018. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal by August 5, 2018.

The position is funded by the Academy of Finland.

Please send informal queries about the post to Juha Huiskonen (juha.huiskonen(at)

Postdoc in cryo-EM of endogenous macromolecular complexes involved in proteostasis

Essential skills
•Hold a PhD degree in a relevant field, such as biochemistry, molecular biology, structural biology or biophysics, and research experience in related fields.
•Strong publication record in leading peer-reviewed journals.
•Excellent familiarity with the current literature and research questions in their own field.
•Demonstrated expertise in working with proteins and macromolecular complexes and in cell culture.
•Good communication skills, including the ability write research articles and reviews and to present work at international meetings.

Desirable skills
•Experience in advanced sample preparation methods such as cell sorting, genome editing, or production of stable cell lines.
•Cryo-EM sample preparation and data collection using modern autoloader instruments.
•Analysis of cryo-EM data using standard methods.
•Experience of independently managing a research project.

Haku päättyy

05.08.2018 23:59 EEST