The Faculty of Medicine at the University of Helsinki conducts high-quality research and provides research-based basic and post-graduate education in medicine and dentistry, psychology and logopedics. Located in the Meilahti-Ruskeasuo Campus, it offers excellent opportunities for close collaboration with both the University Hospital and public-sector research institutes (the National Institute of Health and Welfare, the Finnish Institute of Occupational Health). In addition to teaching and research, the Faculty serves as an important authority in the field of healthcare and actively participates in ethical discourse. The Faculty aims to become one of the most highly reputed medical faculties in the world as well as to maintain and to strengthen its position as a Centre of Excellence in teaching. The Research Programs Unit (RPU) consolidates demonstrated research excellence within the Faculty, with focused units addressing the greatest challenges in human and animal health.

The Laboratory of Dr. Thomas G. McWilliams (Tenure-Track Assistant Professor of Mitochondrial Medicine and Academy of Finland Research Fellow), invites applications for a:

POST-DOCTORAL FELLOW IN TRANSLATIONAL CELL BIOLOGY

Description:

Mitochondrial autophagy (mitophagy) is regarded as a key quality control mechanism to neutralise damaged mitochondria. Dysregulated mitophagy has been linked to a variety of disease states, yet in vivo data supporting this in mammals has been limited due to a lack of tools and reagents. The McWilliams lab employs sophisticated genetics, disease models, cutting edge cell biology assays and rigorous molecular analyses to delineate the regulation of in vivo mitophagy pathways during a variety of physiological contexts (McWilliams et al., 2018 Cell Metabolism; Baumann K. 2018 Nat Rev Mol Cell Bio; McWilliams et al., 2016 Journal of Cell Biology). Building upon our recent discoveries, the successful candidate will exploit the resources of the lab and its close collaborators to investigate in vivo mitophagy during specific disease states. You will be expected to seamlessly integrate into a young and dynamic team with a vibrant international atmosphere. This position is fully funded by the Novo Nordisk Foundation and is available from August 2018 for up to three years.

Candidate Specification:

Essential:
-PhD in a relevant biomedical discipline with a strong academic track record.
-First-author research paper in an internationally recognised, peer-reviewed journal (published, in press or under review).
-Demonstrated research background in cell biology: hands on experience with mouse models, microscopy and primary cell culture is considered a distinct advantage.
-A collegial team player with a resourceful attitude and excellent interpersonal skills: capable of contributing to collaborative projects, as well being able to work and plan independently.
-Outstanding critical thinking skills and excellent English communication skills (written, verbal).
-Basic knowledge of statistics and commitment to rigorous experimental standards.

Desirable:
-Strong background in metabolism, membrane biology or protein biochemistry.
-Experience in preparation of mammalian tissues for histology, immunohistochemistry.
-Expertise in high resolution microscopy and image analysis.

This post is available with an initial one-year contract and possibility of a two-year extension. A 6-month trial period will be applied. Salary will be commensurate with the credentials and previous experience of the post-doctoral researcher.

Further Particulars:
In addition to having the opportunity to perform research, attend conferences, mentor students & enhance their communication skills - the successful candidate will benefit from a supportive research environment with the opportunity for tailored mentoring, consistent with the particular career trajectory of their interest. Our laboratory has direct access to state-of-the-art instrumentation, facilities and cutting-edge multidisciplinary expertise for all aspects of this project. The laboratory further benefits from an extensive collaborative network and is an associated laboratory of FinMIT: a renowned Finnish Centre of Excellence for Mitochondrial Research. Located in the modern surroundings of Biomedical Helsinki, our lab directly interfaces with leading scientists and clinicians in the dynamic Meilahti campus, set against the backdrop of Helsinki just minutes away: a thriving cosmopolitan European capital. Finland is an unrivalled leader in education, innovation, gender equality and consistently ranked as one of the best places in the world to live.

The application should include: a personal statement, a detailed CV and contact details for three referees, and be submitted as a single PDF document through the University of Helsinki electronic recruitment system by clicking on ”Apply for job”. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.

Closing date for applications is 02 July 2018.

Informal enquires may be directed to Dr. McWilliams at thomas.mcwilliams(at)helsinki.fi

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02.07.2018 23:59 EEST