Selected recent publications
- Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Kraft M, Schoofs H, Petkova M, Andrade J, Grosso AR, Benedito R, Roo AK, Boon LM, Vikkula M, Kapp FG, Hägerling R, Potente M, Mäkinen T. Nat Cardiovasc Res (2025). doi: 10.1038/s44161-025-00655-9
- Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium. Schoofs H, DaubelN, Schnabellehner S, Grönloh MLB, Palacios MartínezS, Halme A, Marks AM, Jeansson M, BarcosS, Brakebusch C, Benedito R, Engelhardt B, Vestweber D, Gängel K, Linsenmeier F, Schürmann S, Saharinen P, van Buul JD, Friedrich O, Smith RS, Majda M, Mäkinen T. Nature (2025). doi.org/10.1038/s41586-025-08724-6
- Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation. Petkova M, Kraft M, Stritt S, Martinez-Corral I, OrtsäterH, Vanlandewijck M, Jakic B, Baselga E, Castillo SD, Graupera M, Betsholtz C, Mäkinen T. J Exp Med 220:e20220741 (2023). doi.org/10.1084/jem.20220741
- Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. Hernández Vásquez MN, Ulvmar MH, González-Loyola A, Kritikos I, Sun Y, He L, Halin C, Petrova TV, Mäkinen T. EMBO J 40:e107192 (2021). doi.org/10.15252/embj.2020107192
- PI3K-mediated crosstalk between angiopoietin and vascular endothelial growth factor C signaling pathways is required for lymphangiogenesis. Korhonen EA, Jha SK, Murtomäki A, Anisimov A, Pink A, Stritt S, Zhang Y, Stanczuk L, Sun Z, Kapiainen E, Singh A, Sultan I, Leppänen VM, Eklund L, He Y, Augustin HG, Saharinen P, Mäkinen T, Alitalo K. J Clin Invest 132(15):e155478 (2022). doi.org/10.1172/JCI155478
- Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation. Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Diez SC, Brouillard P, Libbrecht L, Graupera M, Alitalo K, Boon L, Vikkula M, Mäkinen T. Nat Commun 11:2869 (2020). doi.org/10.1038/s41467-020-16496-y
- EphrinB2-EPHB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. Frye M, Stritt S, Ortsäter H, Hernandez-Vasquez M, Kaakinen M, Vicente A, Wiseman J, Eklund L, Martinez-Torrecuadrada JL, Vestweber D, Mäkinen T. eLife 9:e57732 (2020). doi.org/10.7554/eLife.57732
- Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Frye M, Taddei A, Dierkes C, Martinez-Corral I, Fielden M, Ortsäter H, Kazenwadel J, Calado DP, Ostergaard P, Salminen M, He L, Harvey N, Kiefer F, Mäkinen T. Nat Commun 9:1511 (2018). doi.org/10.1038/s41467-018-03959-6
- Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms. Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo, K, Mäkinen T. Nat Commun 9:1296 (2018). doi.org/10.1038/s41467-018-03692-0
- Non-venous origin of dermal lymphatic vasculature. Martinez-Corral I, Ulvmar MH, Stanczuk L, Tatin F, Kizhatil K, John SWM, Alitalo K, Ortega S, Makinen T. Circ Res 116:1649-1654 (2015). doi.org/10.1161/CIRCRESAHA.116.306170
- cKit lineage hemogenic endothelium-derived cells contribute to mesenteric lymphatic vessels. Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Lavina B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T. Cell Rep 10:1708-1721 (2015). doi.org/10.1016/j.celrep.2015.02.026