SELECTED RECENT PUBLICATIONS

 

  1. Miroshnikova YA, Le, HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Höppner N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA (2018) A biomechanical network of adhesion forces and cell mechanics couples proliferation and differentiation to drive epidermal stratification. Nat Cell Biol 20:69-80.
  2. Chacon-Martinez CA, Klose M, Niemann C, Glauche I, Wickström SA. (2016). Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. EMBOJ. 36, 151-164. Highlighted by EMBOJ News&Views, Faculty of 1000
  3. Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol. 18, 864-875. Highlighted by Nature Reviews Molecular Cell Biology, Faculty of 1000
  4. Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA (2015). Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun. 6:8198
  5. Radovanac K, J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fässler R, Wickström SA. (2013). Stabilization of Integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBOJ. 32, 1409-1424.

ALL PUBLICATIONS

2018

Miroshnikova YA, Le, HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Höppner N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA (2018) A biomechanical network of adhesion forces and cell mechanics couples proliferation and differentiation to drive epidermal stratification. Nat Cell Biol 20:69-80.

Nüchel J, Zuk A, Schönborn K, Rabenhorst A, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, and Eckes B. (2018) TGFβ1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators. Autophagy 3, 1-51.

2017

Rübsam M, Mertz AF, Kubo A, Marg S, Ziegler W, Jungst C, Schauss A, Horsley V, Dufresne E, Amagai M. Wickström SA, and Niessen CM. (2017) E-cadherin integrates EGFR signaling and mechanotransduction to control tissue polarization and skin barrier function. Nat Commun 8, 1250.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkötter PT, Huber TB, Wickström SA, Benzing T, Schermer B. (2017). YAP-mediated mechanotransduction determines the podocyte's response to injury. Science Signaling 10(474). pii: eaaf8165

Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM. (2017). Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective. Cold Spring Harb Perspect Biol. 2017 Sep 11. pii: a029207

Elzeneini E, and Wickström SA. (2017). Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis. J Cell Biol; 216, 2607-2610

Miroshnikova YA, Nava MM, and Wickström, SA. (2017) Emerging roles of mechanical forces in chromatin regulation. J Cell Sci. 130, 2243-2250.

2016

Chacon-Martinez CA, Klose M, Niemann C, Glauche I, Wickström SA. (2016). Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. EMBOJ. 36, 151-164. Highlighted by EMBOJ News&Views, Faculty of 1000

Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol. 18, 864-875. Highlighted by Nature Reviews Molecular Cell Biology, Faculty of 1000

Krenn PW, Hofbauer SW, Pucher S, Hutterer E, Hinterseer E, Asslaber D, Sternberg C, Neureiter D, Aberger F, Wickström SA, Egle A, Greil R, Hartmann TN. (2016). Integrin-linked kinase is induced by TNFα-NF-κB signals and required for centrosome clustering in chronic lymphocytic leukemia cells. Cancer Res. 76, 2186-2196.

2015

Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA (2015). Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun. 6:8198

Rahn E, Petermann P, Their K, Bloch W, Morgner J, Wickström, SA, Knebel-Mörsdorf D. (2015) Invasion of Herpes Simplex Virus Type 1 into Murine Epidermis: An Ex Vivo Infection Study, J Invest Dermatol. 135, 3009-3016.

Schneider D, and Wickström SA. (2015). Force generation and transmission in keloid fibroblasts: Dissecting the role of mechanosensitive molecules in cell function. Exp Dermatol. 8, 574-575.

2014

Schiefermeier N, Scheffler JM, de Araujo ME, Stasyk T, Yordanov T, Ebner HL, Offterdinger M, Munck S, Hess MW, Wickström SA, Lange A, Wunderlich W, Fässler R, Teis D, LA. (2014). The late endosomal p14/MP1 (Lamtor2/3) complex regulates focal adhesion dynamics during cell migration. J Cell Biol. 205, 525-540.

Eckes B, Krieg T, and Wickström SA. (2014). Role of integrin signaling through Integrin-linked kinase (ILK) in skin physiology and pathology. Exp Dermatol. 23, 453-456.

2013

Traub S, J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA. (2013). The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165. Biomaterials. 34, 5958-5968.

Radovanac K, J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fässler R, Wickström SA. (2013). Stabilization of Integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBOJ. 32, 1409-1424.

Malan D, Elischer A, Hesse M, Wickström SA, Fleischmann BK, W. (2013). Deletion of the integrin-linked kinase impairs endothelial cell development and function due to defective caveolar-based signaling. Development 140, 987-95

Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, Mann M. (2013). In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Reports. 21, 552-66.

Morgner J, and Wickström SA, (2013). The weakest link: A new paradigm for stabilizing the integrin-actin connection. Cell Cycle. 12, 2929-2930.

Ghatak, S, Morgner J, and Wickström SA. (2013). ILK: a pseudokinase with a unique function in the integrin-actin linkage. Biochem Soc Trans. 41, 995-1001.

2011

Wickström SA,* and Fässler R. (2011). Regulation of membrane traffic by integrin signaling. Trends Cell Biol. 21, 266-273. * Corresponding author

Wickström SA,*  Radovanac K, and Fässler R. (2011).Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol. 3, a005116. * Corresponding author

Wickström SA*, Lange A, Hess MW, Polleux J, Spatz JP, Krüger M, Pfaller K, Lambacher A, Bloch W, Mann M, Huber LA, Fässler R. (2010). Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell. 19, 574-588. *Corresponding author; Highlighted by Faculty of 1000 and Nature Reviews Molecular Cell Biology

Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R. (2010). CYLD negatively regulates cell cycle progression by inactivation of HDAC6 and accumulation of acetylated tubulin. EMBO J. 29, 131-144.

Wickström SA, Lange A, Montanez E, and Fässler R. (2010). The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J. 29, 281-291.

Legate KR*, Wickström SA*, and Fässler R. (2009). Genetic and cell biological analysis of integrin inside-out signaling. Genes Dev. 23, 397-418. * Equal contribution

Wickström SA and Fässler R. (2009). Integrins anchor the invasive machinery. Dev Cell. 17, 158-160.

Montanez E, Wickström SA, Altstätter J, Chu H, Fässler R. (2009). α-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J. 28, 3132 - 3144.

Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R. (2009). Integrin-linked kinase is an adaptor with essential functions during mouse development.  Nature. 461, 1002-1006.

Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M. (2008). Solid Tumor Proteome and Phosphoproteome Analysis by High Resolution Mass Spectrometry. J Proteome Res. 7, 5314–5326.

Wang HV, Chang LW, Brixius K, Wickström SA, Montanez E, Thievessen I, Schwander M, Müller U, Bloch W, Mayer U, Fässler R. (2008). Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol. 180, 1037-1049.

Zhao H, Jutila A, Nurminen T, Wickström SA, J, Kinnunen PK. (2005). Binding of endostatin to phosphatidylserine containing membranes and formation of amyloid fibers. Biochemistry. 44, 2857-2863.

Wickström SA, Alitalo K, and Keski-Oja J. (2005). Endostatin signalling and regulation of endothelial cell – matrix interactions. Adv Cancer Res. 94, 197-229.

Wickström SA and Keski-Oja J. (2005). Degradation products of endothelial basement membranes: their role as tumor suppressor. Duodecim. 121, 27-35. (Article in Finnish)

Wickström SA, Alitalo K, Keski-Oja J. (2004). An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. J Biol Chem. 279, 20178-20185.

Wickström SA, Alitalo K, Keski-Oja J. (2003). Endostatin associates with lipid rafts and induces actin cytoskeleton reorganization via down regulation of RhoA activity. J Biol Chem. 278, 37895-37901.

Wickström SA, Keski-Oja J, and Alitalo K. (2003). Matrix reloaded to circulation hits the tumor target. Cancer Cell.

Wickström SA, Alitalo K, Keski-Oja J. (2002). Endostatin associates with α5β1 integrin and caveolin-1 and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. Cancer Res. 62, 5580-5589.

Wickström SA, Veikkola T, Rehn M, Pihlajaniemi T, Alitalo K, Keski-Oja J. (2001). Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in human endothelial cell cultures. Cancer Res. 61, 6511-6516.

Lehti K, Valtanen H, Wickström SA, Lohi J, J. (2001). Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain. J Biol Chem. 275, 15006-13.