Publications

Recent publications.

  • Induced Pluripotent Stem Cells as a Possible Approach for Exploring the Pathophysiology of Polycystic Ovary Syndrome (PCOS). Khatun M, Lundin K, Naillat F, Loog L, Saarela U, Tuuri T, Salumets A, Piltonen TT, Tapanainen JS. Stem Cell Rev Rep. 2023 Sep 28. doi: 10.1007/s12015-023-10627-w. Epub ahead of print. PMID: 37768523.

  • CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate. Danti L, Lundin K, Sepponen K, Yohannes DA, Kere J, Tuuri T, Tapanainen JS. J Ovarian Res. 2023 Sep 20;16(1):194. doi: 10.1186/s13048-023-01264-5. PMID: 37726790; PMCID: PMC10510196.

  • Reference standards for follicular density in ovarian cortex from birth to sexual maturity. Hassan J, Knuus K, Lahtinen A, Rooda I, Otala M, Tuuri T, Gidlöf S, Edlund E, Menezes J, Malmros J, Byström P, Sundin M, Langenskiöld C, Vogt H, Frisk P, Petersen C, Damdimopoulou P, Jahnukainen K. Reprod Biomed Online. 2023 Oct;47(4):103287. doi: 10.1016/j.rbmo.2023.103287. Epub 2023 Jul 17. PMID: 37603956.

  • Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells. Sepponen K, Lundin K, Yohannes DA, Vuoristo S, Balboa D, Poutanen M, Ohlsson C, Hustad S, Bifulco E, Paloviita P, Otonkoski T, Ritvos O, Sainio K, Tapanainen JS, Tuuri T. Differentiation. 2022 Aug 30:S0301-4681(22)00062-7. doi: 10.1016/j.diff.2022.08.001. Epub ahead of print. PMID: 36114074.
  • Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation. Lundin K, Sepponen K, Väyrynen P, Liu X, Yohannes DA, Survila M, Ghimire B, Känsäkoski J, Katayama S, Partanen J, Vuoristo S, Paloviita P, Rahman N, Raivio T, Luiro K, Huhtaniemi I, Varjosalo M, Tuuri T, Tapanainen JS. Mol Hum Reprod. 2022 Apr 29;28(5):gaac012. doi: 10.1093/molehr/gaac012. 
  • DUX4 is a multifunctional factor priming human embryonic genome activation. Vuoristo S, Bhagat S, Hydén-Granskog C, Yoshihara M, Gawriyski L, Jouhilahti EM, Ranga V, Tamirat M, Huhtala M, Kirjanov I, Nykänen S, Krjutškov K, Damdimopoulos A, Weltner J, Hashimoto K, Recher G, Ezer S, Paluoja P, Paloviita P, Takegami Y, Kanemaru A, Lundin K, Airenne T, Otonkoski T, Tapanainen J, Kawaji H, Murakawa Y, Bürglin T, Varjosalo M,  Johnson M, Tuuri T, Katayama S, Kere J: iScience 25: 104137, 2022
  • Proteome-wide and matrisome-specific atlas of the human ovarycomputes fertility biomarker candidates and open the way for precision oncofertility. Ouni E, Nedbal V, Da Pian M, Cao H, Haas KT, Peaucelle A, Van Kerk O, Herinckx G, Marbaix E, Dolmans MM, Tuuri T, Otala M, Amorim CA, Vertommen D: Matrix Biology 109:91-120, 2022
  • Estradiol Valerate vs Ethinylestradiol in Combined Oral Contraceptives: Effects on the Pituitary-Ovarian Axis. Haverinen A, Luiro K, Kangasniemi MH, Piltonen TT, Hustad S, Heikinheimo O, Tapanainen JS. J Clin Endocrinol Metab. 2022 Jun 16;107(7):e3008-e3017. doi: 10.1210/clinem/dgac150. PMID: 35279718.
  • Women with polycystic ovary syndrome have poorer work ability and higher disability retirement rate at midlife: a Northern Finland Birth Cohort 1966 study. Kujanpää L, Arffman RK, Vaaramo E, Rossi HR, Laitinen J, Morin-Papunen L, Tapanainen J, Ala-Mursula L, Piltonen TT. Eur J Endocrinol. 2022 Aug 4;187(3):479-488. doi: 10.1530/EJE-22-0027. PMID: 35900320; PMCID: PMC9422246.
  • Time and dose-dependent effects of FGF8-FGFR1 signaling in GnRH neurons derived from human pluripotent stem cells. Yellapragada V, Eskici N, Wang Y, Madhusudan S, Vaaralahti K, Tuuri T, Raivio T: Disease Models and Mechanisms 15(8):dmm049436, 2022
  • A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis. Ouni E, Peaucelle A, Haas KT, Van Kerk O, Dolmans MM, Tuuri T, Otala M, Amorim CA:  Nat Communications 12:5603, 2021
  • Small RNA expression and miRNA modification dynamics in human oocytes and early embryos. Paloviita P, Hydén-Granskog C, Yohannes DA, Paluoja P, Kere J, Tapanainen JS, Krjutškov K, Tuuri T, Võsa U, Vuoristo S: Genome Res 31:1474-1485, 2021
  • Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells. Lund C, Yellapragada V, Vuoristo S, Balboa D, Trova S, Allet C, Eskici N, Pulli K, Giacobini P, Tuuri T, Raivio T: Dis Model Mech 13:3, 2020 (shared last author)
  • Complement in Human Pre-implantation Embryos: Attack and Defense. Reichhardt MP, Lundin K, Lokki AI, Recher G, Vuoristo S, Katayama S, Tapanainen JS, Kere J, Meri S, Tuuri T. Front Immunol. 2019 Sep 18;10:2234. doi: 10.3389/fimmu.2019.02234.
  • Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG. Koistinen H, Koel M, Peters M, Rinken A, Lundin K, Tuuri T, Tapanainen JS, Alfthan H, Salumets A, Stenman UH, Lavogina D. Mol Cell Endocrinol. 2019 Jan 5;479:103-109. doi: 10.1016/j.mce.2018.09.006.
  • Demographic and evolutionary trends in ovarian function and aging. Laisk T, Tšuiko O, Jatsenko T, Hõrak P, Otala M, Lahdenperä M, Lummaa V, Tuuri T, Salumets A, Tapanainen JS. Hum Reprod Update. 2019 Jan 1;25(1):34-50. doi: 10.1093/humupd/dmy031.
  • rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology. Marjonen H, Auvinen P, Kahila H, Tšuiko O, Kõks S, Tiirats A, Viltrop T, Tuuri T, Söderström-Anttila V, Suikkari AM, Salumets A, Tiitinen A, Kaminen-Ahola N: Clin Epigenetics.10:80, 2018
  • The Role of Sequential BMP Signaling in Directing Human Embryonic Stem Cells to Bipotential Gonadal Cells. Sepponen K, Lundin K, Knuus K, Väyrynen P, Raivio T, Tapanainen JS, Tuuri T. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4303-4314. doi: 10.1210/jc.2017-01469.
  • Optimizing bone morphogenic protein 4-mediated human embryonic stem cell differentiation into trophoblast-like cells using fibroblast growth factor 2 and transforming growth factor-β/activin/nodal signalling inhibition. Koel M, Võsa U, Krjutškov K, Einarsdottir E, Kere J, Tapanainen J, Katayama S, Ingerpuu S, Jaks V, Stenman UH, Lundin K, Tuuri T, Salumets A. Reprod Biomed Online. 2017 Sep;35(3):253-263. doi: 10.1016/j.rbmo.2017.06.003.
  • Research resource: small RNA-seq of human granulosa cells reveals miRNAs in FSHR and aromatase genes. Velthut-Meikas A, Simm J, Tuuri T, Tapanainen JS, Metsis M, Salumets A. Mol Endocrinol. 2013 Jul;27(7):1128-41. doi: 10.1210/me.2013-1058.