Myocardial infarction (MI) is a common cause of death and the prevalence of risk factors for MI, such as hypertension, hypercholesterolemia and diabetes mellitus, are prevalent and may increase as a result of population ageing and rising obesity rates. Statin drug therapy is an important part of heart disease prevention. Poor adherence both hampers the effectiveness of the medications and increases the risk of recurrence and mortality. The aim is to study the prevalence of poor adherence to statin drug therapy after myocardial infarction and how adherence is affected by household structure and other social factors. The analyses are based on the nationwide registration of drugs and hospitalization in Finland.

Key words: medication adherence, cardiovascular disease, statins, household structure

Researcher: Kimmo Herttua

Alcohol misuse was ranked in the top three risk factors for global disease burden in 2010. Pricing and availability of alcohol have been regarded as effective tools in reducing harm. Changes in alcohol prices have been documented to be inversely associated with changes in consumption and alcohol-related harm. Much of the evidence on this issue is based on cross-sectional state-level time series data and natural experiments have been called for. The changes in Finnish alcohol legislation that occurred in 2004 can be considered as a natural experiment. In the European context, research on the association between prices of alcohol and alcohol-related harm is scarce or non-existent. The objectives of this study are (i) to estimate the impact of changes in alcohol policy of  2004 in Finland on alcohol-related, cardiovascular and all-cause mortality, hospitalization related to alcohol, and interpersonal violence according to a wide range of socio-demographic indicators and (ii) to estimate effects of affordability of alcohol and minimum prices of alcohol on alcohol-related mortality and morbidity according to different socio-demographic indicators   The analyses are based on the nationwide registration of hospitalization, causes of death and crimes, and information on alcohol prices and socio-demographic indicators in Finland and other EU countries.

Key words: alcohol drinking, alcohol misuse, price of alcohol, natural experiment, mortality, morbidity, socio-demographic inequalities

Researcher: Kimmo Herttua

It is known that many different factors play a role in leisure-time physical activity behavior. However, a consensus of the factors involved in leisure-time physical activity behavior has not been reached. Genetic studies are a new area of physical activity research. Motives for physical activity have been widely studied but longitudinal studies are still missing. The purpose of this project was to quantify longitudinally genetic and environmental influences on leisure-time physical activity and to examine the associations between motives and longitudinal leisure-time physical activity. The results of the latest longitudinal Finnish twin studies point to the existence of age-specific genetic and environmental influences on leisure-time physical activity. Variations in environmental factors seem to explain the observed deterioration in leisure-time physical activity levels. A decline in genetic influences is seen first from adolescence to young adulthood and again from the age of thirty to the mid-thirties. In the Finnish twin participants, mastery, physical fitness, and psychological state were the major motivation factors associated with consistent leisure-time physical activity behavior. The results also indicate that intrinsic motivation factors may be important for engagement in leisure-time physical activity.

Researcher: Sari Aaltonen

With growing pressure from an ageing population on social and health-care expenditure, it is of major policy importance to analyze the reasons for admission to institutional care at older ages. This study focuses on how different chronic medical conditions, socio-economic factors, living with a spouse, and the death of a spouse are associated with admission among people aged 65 years or older. The findings in this study imply that the future need for institutional care will depend not only on the increasing numbers of older people but also on the development of the prevalence and severity of chronic medical conditions associated with admission, and on older people’s income, housing conditions and access to informal care from their spouse.

Key words: nursing home, institution, long-term care, elderly, socioeconomic position, widowhood, bereavement

Researcher: Elina Einiö

Childhood is a critical phase of life for the formation of the further health risk factor profile. We found that childhood physical development is strictly genetically regulated in several Western (Finnish, Swedish, Danish, Dutch, and US) populations, and genetic factors affect strongly also on cognitive and other mental development. This regulation is also very similar in Japanese and Chinese populations in spite of large ethnic and environmental differences to Western populations. Childhood social environment was found to modify the effects of genetic and environmental factors. Physical development in childhood was associated with metabolic risk factor profile and risk of metabolic diseases in adulthood. At the moment the main focus is to understand better how physical development is associated with mental development in childhood and how societal macro environment modifies the role of genetic and environmental factors behind the physical development of the child.

Key words: childhood, physical development, mental development, genetics, ethnicity, international comparisons

Researchers: Karri Silventoinen and Aline Jelenkovic

Across societies, poor mental and physical health and excess mortality are consistently linked to union dissolution. External and alcohol-related excess mortality is most pronounced immediately after separation, particularly among men, suggesting that psychological support during the separation process is needed to avoid high-risk health behaviors, such as alcohol use as a coping mechanism. Poor mental health explains excess suicide mortality after separation, but particularly among men, separation is a risk factor for suicide even without pre-existing mental health problems. The findings of the project also suggest that mental health is more closely linked to union stability than to whether the union is marital or not. Poor mental health seems to put strain on unions and even hinder the formation of long-term unions. At the moment the main focus of the project is in examining the effects of physical health conditions on subsequent separation risk, and the role of socio-economic disadvantage in shaping these associations. 

Key words: mental health, divorce, marriage, marital transitions, non-marital transitions, cohabitation, separation, psychotropic medication, mortality, physical health

Researchers: Niina Metsä-Simola, Elina Einiö

The overall aim of this EU Horizon2020 funded comparative project is to identify the opportunities offered by the urban environment for the promotion of mental wellbeing and cognitive function of older individuals in Europe. To achieve this, the project will advance understanding by bringing together longitudinal studies across cities in Europe, the US and Canada to unravel the causal pathways and multi-level interactions between the urban environment and the individual determinants of mental wellbeing in older age. The project will examine the causes of variation in mental wellbeing and disorders in old age both within as well as between cities and identify national and urban policies for the prevention and early diagnosis of mental conditions and disorders of older people. This knowledge will contribute to the establishment of preventive strategies in urban settings to promote the mental dimension of healthy ageing, reduce the negative impact of mental disorders on co-morbidities and preserve cognitive function in old age. The specific objectives of MINDMAP are:

  1. To assess the impact of the urban environment on the mental wellbeing and disorders associated with ageing, and estimate the extent to which exposure to specific urban environmental factors and policies explain differences in ageing-related mental and cognitive disorders both within as well as between European cities. The project will assemble and harmonize data from 10 ongoing longitudinal ageing studies across more than 16 cities in Europe, Canada and the United States. This will be complemented by registry data on mortality and hospital discharge, as well as international longitudinal surveys of ageing.
  2. To assess the causal pathways and interactions between the urban environment and the individual determinants of mental health and cognitive ageing in older adults. We will test the hypothesis that mental health and cognitive capacity in old age are shaped by the interaction between specific characteristics of the urban environment and social, biological, behavioural, and psychosocial characteristics. Our study will also asses the interaction between the urban environment and the genetic make-up.
  3. To use agent-based modelling to simulate the effect of prevention and early identification policies specific to urban environments on the trajectories of mental health and cognitive ageing across cities in Europe. Integrating findings from the first two aims into a novel agent-based model, we will use a systems approach to simulate the potential impact of multiple policy and intervention scenarios on the mental and cognitive wellbeing of older populations in European cities.

To achieve these aims, we adopt an interdisciplinary approach that integrates insights and methodological approaches from mental health and psychiatry, biology, epidemiology, epigenetics, geriatrics, geography and social sciences. To achieve impact, we model the impact of concrete features of the urban environment, policies and interventions on common mental health disorders in European cities. We involve a wide number of stakeholders at the regional, national and European level to translate knowledge into practice. A major legacy of the project will be a research infrastructure of harmonized international urban cohort studies of ageing and mental health. This infrastructure will advance the study of the interactions between contextual exposures in the urban environment and individual determinants of mental health and cognitive ageing within and beyond the MINDMAP project.

MINDMAP projet homepage

Researchers: Lasse Tarkiainen, Kaarina Korhonen, Heta Moustgaard

Rapid increase in the standard of living, unparalleled to any phase of human history, has leaded to dramatic increase of obesity and metabolic diseases in western societies. Genetic factors explain important part of the individual differences in body mass index and their role increases from childhood to adulthood. Genetic factors can also be found behind eating behavior and other risk factors of obesity. However socio-economic factors and cognitive ability are also associated with obesity and metabolic diseases. Genetic and environmental factors interact and their effects on metabolic factors vary between different social contexts. In the future we aim to study the complex relationships between genetic factors, socio-economic micro-environment and societal macro-environment in the formation of metabolic disorders and diseases.

Key words: obesity, metabolic diseases, genetics, socio-economic factors, gene-environment interactions

Researcher: Karri Silventoinen

Parental and childhood health may have significant consequences for educational and labour market outcomes. Acute health shocks and chronic conditions are known to affect employment careers among middle-aged adults, but less is known about the social consequences of illness for children and youth.

We use large, internationally exceptional register-based data on families with annual repeated measurements on parents and children over several decades to quantify the social consequences of parental and childhood health problems and to clarify the causal mechanisms through which they may affect educational and employment trajectories in youth.

Health-related marginalization in youth may have long-term consequences in terms of unemployment and labour market exclusion. These present a major strain on both the individual and the social protection system. By identifying key mechanisms of health related selection the results will inform policy interventions aiming at reducing such harm.

Key words: childhood health, parental health, educational outcomes, employment outcomes, intergenerational transmission

Researchers: Heta Moustgaard, Hanna Remes, Niina Metsä-Simola, Janne Mikkonen and Mikko Aaltonen

Among the many concerns relating to population ageing is the growing number of people living with Alzheimer’s disease and other types of dementia. Progressive dementia is one of the most important causes of disability at older ages and people with dementia commonly need long-term institutional care at the end of life. This project will enhance understanding of the dynamics between socioeconomic, demographic and health-related factors that contribute to dementia risk throughout the life-course and the use of institutional long-term care with dementia.

Keywords: Alzheimer’s disease, dementia, elderly, life course, long-term care, socioeconomic position, nursing home

Researcher: Kaarina Korhonen

Key publications:

Korhonen, K., Einiö, E., Leinonen, T., Tarkiainen, L., & Martikainen, P. (2018). Time-varying effects of socio-demographic and economic factors on the use of institutional long-term care before dementia-related death: A Finnish register-based study. PloS one, 13(6), e0199551.

Korhonen, K., Einiö, E., Leinonen, T., Tarkiainen, L., & Martikainen, P. (2020). Midlife socioeconomic position and old-age dementia mortality: a large prospective register-based study from Finland. BMJ open, 10(1)

The death of a spouse is one of the biggest emotional shocks in life, and it is known to have a major effect on health. This study will expand our previous work on the effects of widowhood by studying short-term hospitalizations before and after the death of a spouse. We will use panel data and methods to examine the risks of being hospitalized due to various diseases and accidents. Our research contributes to the debate on adverse consequences of stressful life events.

Key words: widowhood, bereavement, hospital use

Researcher: Elina Einiö

Growing family instability is suggested to increase the importance of multigenerational ties in contemporary societies. Previous studies propose that contacts with grandparents may improve children’s adjustment to parental separation, but it is unclear how grandparental characteristics shape the short-term and long-term mental health effects that parental separation has on children. Little is also known about the importance of grandparents for the separating parents’ own mental health. This study aims to fill these gaps. Using longitudinal register-data on all Finnish families with children, as well as their grandparents, we examine how the effect of parental separation on children’s mental health, and the association between parents’ separation and their own mental health, are shaped by grandparental characteristics.

Key words: mental health, union stability, intergenerational effects

Researchers: Niina Metsä-Simola, Hanna Remes