New Single-Cell Atlas Reveals the Human Pancreas' Remarkable Plasticity

Driven by the ambition to create a definitive multi-omic atlas of the human pancreas, ESPACE spans key biological states from development and healthy adulthood to type 2 diabetes. Through the integration of single-cell transcriptomics, chromatin accessibility, spatial transcriptomics, and multiplex protein imaging across over 4 million cells from 57 donors, we generated an unparalleled resource for understanding pancreatic biology.