Publications

• A comprehensive p75 neurotrophin receptor gene network and pathway analyses identifying new target genes, Nature Scientific Reports
• Kainate receptor auxiliary subunit NETO2-related cued fear conditioning impairments associate with defects in amygdala development and excitability, Eneuro
• Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic deficits in an AD mouse model, International Journal of Molecular Sciences
• Inactivation of the GATA cofactor ZFPM1 results in abnormal development of dorsal raphe serotonergic neuron subtypes and increased anxiety-like behaviour, Journal of Neuroscience
• Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats, European Journal of Neuroscience
• Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2, Journal of Biological Chemistry
• TrkB activation in Parvalbumin interneurons orchestrates cortical plasticity, bioRxiv

• Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish, Nature Scientific Reports
• TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins, Frontiers in Molecular Neuroscience
• Fluoxetine‐induced plasticity in the visual cortex outlasts the duration of the naturally occurring critical period, European Journal of Neuroscience
• Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor: “Siamese Twins” in Antidepressant Action, Biological Psychiatry Journal
• Culturing primary neurons from rat hippocampus and cortex, Neuronal Signaling
• Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors, BioRxiv

• Social Learning Requires Plasticity Enhanced by Fluoxetine Through Prefrontal Bdnf-TrkB Signaling to Limit Aggression Induced by Post-Weaning Social Isolation, Nature
• Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia, Nature Scientific Reports
• Longitudinal two-photon imaging in the somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine, Nature Scientific Reports
• Automated analysis of images for molecular quantification in immunohistochemistry, Elsevier Heliyon
• Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN, Elsevier Neuropharmacology
• Elastase-2 Knockout Mice Display Anxiogenic- and Antidepressant-Like Phenotype: Putative Role for BDNF Metabolism in Prefrontal Cortex, Molecular Neurobiology
• Effects of the Antidepressant Fluoxetine on the Somatostatin Interneurons in the Basolateral Amygdala, Neuroscience Journal
• iPlasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants, Psychiatry and Clinical Neuroscience
• Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania, PeerJ

• Isoflurane produces antidepressant effects and induces TrkB signaling in rodents, Nature Scientific Reports
• Neuronal plasticity and neurotrophic factors in drug responses, Nature Molecular Psychiatry
• Depolarizing γ‐aminobutyric acid contributes to glutamatergic network rewiring in epilepsy, American Neurological Association
• Brain-derived neurotrophic factor in mood disorders and antidepressant treatments, Elsevier Neurobiology of Disease
• Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression, Neuroscience and Biobehavioral Reviews
• Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses, Elsevier Neuropharmacology
• Chronic imaging through “transparent skull” in mice, PLoS One

• Editorial, Neurobiology of Disease
• Neurochemical Phenotype of Reelin Immunoreactive Cells in the Piriform Cortex Layer II, Frontiers in Cellular Neuroscience
• Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex, Frontiers in Cellular Neuroscience
• Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs, FASEB Journal
• Actin Tyrosine-53-Phosphorylation in Neuronal Maturation and Synaptic Plasticity, Journal of Neuroscience
• Trophic Factors: Neurotrophic Factors, Neuroscience in the 21st Century

• GDNF is not required for catecholaminergic neuron survival in vivo, Nature Neuroscience
• Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling, Cell - Developmental Cell
• Evidence for Competition for Target Innervation in the Medial Prefrontal Cortex, Cerebral cortex
• Distinct effects of perinatal exposure to fluoxetine or methylmercury on parvalbumin and perineuronal nets, the markers of critical periods in brain development, International Journal of Developmental Neuroscience
• NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in the brain – Restoration by chronic amitriptyline, Elsevier European Neuropsychopharmacology
• The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals With Schizophrenia: A Single-Blind, Randomized Clinical Trial, Schizophrenia Bulletin
• Interplay Between Nitric Oxide and Brain-Derived Neurotrophic Factor in Neuronal Plasticity, CNS & Neurological Disorders

• Nimodipine Activates TrkB Neurotrophin Receptors and Induces Neuroplastic and Neuroprotective Signaling Events in the Mouse Hippocampus and Prefrontal Cortex, Cell Molecular Neurobiology
• TrkB overexpression in mice buffers against memory deficits and depression-like behavior but not all anxiety- and stress-related symptoms induced by developmental exposure to methylmercury, Frontiers in Behavioral Neuroscience
• Mice with altered BDNF signaling as models for mood disorders and antidepressant effects, Frontiers in Behavioral Neuroscience
• Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells, Elsevier Journal of Neuroscience Methods
• Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain, Cerebral Cortex
• Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons, International Journal of Neuropsychopharmacology
• Neurotrophins and Psychiatric Disorders, Neurotrophic Factors- Handbook of Experimental Pharmacology
• Aivosairaudet ovat kalleimmat kansantautimme, Duodecim

• Neuronal plasticity and antidepressant actions, Cell
• The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease, PLOS One
• Trophic Factors: Neurotrophic Factors, Neuroscience in the 21st Century
• BDNF in fragile X syndrome, Elsevier Neuropharmacology
• Neuronal Network Plasticity and Recovery From Depression, JAMA Psychiatry
• Gene Expression Patterns Underlying the Reinstatement of Plasticity in the Adult Visual System, Hindawi Neural Plasticity

• Sleep homeostasis and depression: studies with the rat clomipramine model of depression, Neuroscience
• Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis, Journal of Biological Chemistry
• Brain-derived neurotrophic factor expression after acute administration of ethanol, European Journal of Pharmacology
• Treatment of Neurodevelopmental Disorders in Adulthood, Journal of Neuroscience
• Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice, Elsevier Neurobiology of Aging
• The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf k/o heterozygous null mice, Elsevier Neuropharmacology
• The Aromatase Gene CYP19A1: Several Genetic and Functional Lines of Evidence Supporting a Role in Reading, Speech and Language, Behavioral Genetics
• The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development, PLUS One
• IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels, Hindawi Neural Plasticity
• Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits, Genes Brain and Behavior

• Fear Erasure in Mice Requires Synergy Between Antidepressant Drugs and Extinction Training, Science
• Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus, Elsevier Neuropharmacology
• An increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy, Elsevier Neurobiology of Disease
• Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons, PLUS One
• A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress, Genes Brain and Behavior

• BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse, Elsevier Neurobiology of Disease
• Effects of Maternal Smoking and Exposure to Methylmercury on Brain-Derived Neurotrophic Factor Concentrations in Umbilical Cord Serum, Toxicological Sciences
• Darkness Reduces BDNF Expression in the Visual Cortex and Induces Repressive Chromatin Remodeling at the BDNF Gene in Both Hippocampus and Visual Cortex, Cellular and Molecular Neurobiology
• Riittääkö että masennuslääke vain otetaan, Dosis : farmaseuttinen aikakauskirja
• Neurotrophic Factors and Antidepressant Action: Recent Advances, Modern Trends in Pharmacopsychiatry

2008

• Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro, Molecular Biology of the Cell

2002

• Expression Profiling to Understand Actions of NMDA/Glutamate Receptor Antagonists in Rat Brain, Neurochemical Research

• Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders, Elsevier European Neuropharmacology

1998

• Regulation of brain-derived neurotrophic factor mRNA levels in the hippocampus by neuronal activity, Elsevier Progress in Brain Research

1995

• Transcriptional induction of rat mineralocorticoid receptor gene in neurons by corticosteroids, Journal of Molecular Endocrinology

• Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus, Elsevier Neuroscience

1994

• Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus,
  
  Journal of Cerebral Blood Flow & Metabolism
• Glucocorticoids and Neurotrophin Gene Regulation in the Nervous System, Annals of New York Academy of Sciences

• Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM, Elsevier Developmental Brain Research

• BCL-2 Messenger RNA is localized in neurons of the developing and adult rat brain, Elsevier Neuroscience

• Brain-derived neurotrophic factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus, Elsevier Developmental Neuroscience

1993

• Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar Granule Cells Promotes Purkinje Cell Differentiation, Journal of Cell Biology

• Long-Term Alterations in NMDA-Sensitive l-[3H]Glutamate Binding in the Rat Hippocampus Following Fimbria-Fornix Lesioning, Elsevier Experimental Neurology

• Differential Effects of MK-801 on Brain-Derived Neurotrophic Factor mRNA Levels in Different Regions of the Rat Brain, Experimental Neurology

• Effects of neurotransmitters and hormones on neuronal production of neurotrophins, Seminars in Neuroscience

• NMDA-sensitive [3H]glutamate binding in the epileptic rat hippocampus: an autoradiographic study, Neuroreport

• The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus, Neuroreport

1992

• Cerebellar GABA-A Receptors in Two Rat Lines Selected for High and Low Sensitivity to Moderate Alcohol Doses: Pharmacological and Genetic Studies, Elsevier Alcohol
• Distribution of histamine in the rat kidney during pregnancy and development, Cell and Tissue Research

• Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation, Journal of Cell Biology

1991

• Kainic acid-induced changes in histamine-immunoreactive nerve fibers in the rat brain, Agents and Actions

• Different effects of chronic Na+, Cl-, and K+ depletion on brain vasopressin mRNA and plasma vasopressin in young rats, Cellular and Molecular Neurobiology