Brunello C.A., Schuberth L.E., Didio F., Enkavi G., Lyytikainen E., Gil Ortiz M., Boeykens A., Avila Marti J.C., Pastor Munoz P., Mattila H.S., Kaptan S., Le Joncour V., Normann C., Vattulainen I., Vestring S., Castrén E. The neurosteroid allopregnanolone promotes neuroplasticity by directly binding to TRKB receptor. Submitted.
BrunelloC.A., Gil Ortiz M. , Pastor Muñoz P., Araujo J.P., Caceres Pajuelo J.E., Avila Marti J.C., Lyytikainen E., Tonelli S., Didio G., Le Joncour V., Castrén E. BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors. Submitted.
Didio G., Aitta-aho T., Umemori J., Castrén E. The BDNF/TrkB pathway in Somatostatin-expressing neurons suppresses cocaine-seeking behaviour. BioRxiv,, 2024.
Liu W., Vesterinen M., Andersson A., Partanen P., Knapič S. Juvonen J.J., Siebenhühner F., Salonen A., Renvall H., Ilmoniemi R.J., Castrén E., Isometsä E. Van De Ville D., Palva J.M., Palva S. MEG oscillation-based functional connectivity identifies clinically relevant depression phenotypes. Nature Mental Health, in press, 2026.
Gallo M.T., Virenque A., Golinelli A., Fumagalli F., Castrén E, Brivio P., Calabrese F. From early-life fluoxetine exposure to lifelong, sex-specific behavioral changes: decoding the dynamics of sensitive periods. Mol. Psychiatry, 31: 1205–1215. doi: 10.1038/s41380-025-03223-6, 2026.
Kiiso T., Partanen P., Jacobs K., Varga B.A., Palva S., Palva J.M., Castrén E., Balin R. Surgical Protocol for a Large, Resealable Cranial Window Enabling Longitudinal, Multi-Modal Electrophysiology Recordings of the Mouse Default Mode Network. J. Vis. Exp. (231), e70337, doi:10.3791/70337, 2026.
Brunello C., Pastor Muñoz P., Araujo J.P., Seiffert N., Kaurinkoski K., Casarotto P., Biojone C., Castrén E. Fingolimod acutely facilitates activation of TRKB in a BDNF-dependent manner. Cell. Mol. Neurobiol., 2025, 10.1007/s10571-026-01774-y.
Jetsonen E., Suleymanova I., Didio G., Castrén E*., Umemori J*. Chronic treatment with fluoxetine regulates mitochondrial features and plasticity-associated transcriptomic pathways in parvalbumin-positive interneurons of prefrontal cortex. Neuropsychopharmacology, 50(12):1864-1874. doi: 10.1038/s41386-025-02219-8, 2025.
Ribeiro-Rodrigues L., Fonseca-Gomes J., Paulo S.L., Viais R., Ribeiro F.F., Miranda-Lourenço C., Mouro F.M., Belo R.F., Ferreira C.B., Tanqueiro S.R., Fereira-Manso M., Umemori J., Castrén E., Paiva V.H., Sebastião A.M., Aronica E., Rainha Campos A., Bentes C., Xapelli S, Diógenes M.J. Cleavage of the TrkB-FL Receptor During Epileptogenesis: Insights from a Kainic Acid-Induced Model of Epilepsy and Human Samples. Pharmacological research 215:107707, 2025. doi: 10.1016/j.phrs.2025.107707.
2024
Fonseca-Gomes J., Rodrigues T.M., Vaz S.H., Ramalho R.M., Miranda H.V., Tanqueiro S., Bordino C., Ramalho M.J., Manso M.F., Costa-Coelho T., Miranda-Lourenço C., Belo R.F., Ferreira C., Neves V., Rombo D.M., Martins I.C., Jerónimo-Santos A., Caetano A., Manso N., Mäkinen P., Marttinen M., Takalo M., Bremang M., Pike I., Haapasalo A., Loureiro J.A., Pereira M.C., Santos N.S., Outeiro T.F., Castanho M.A.R.B., Fernandes A., Hiltunen M., Duarte C.B. Castrén E., de Mendonça A. Sebastião A.M. and Diógenes M.J. A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer’s Disease. Molecular therapy, 33(1):421. doi: 10.1016/j.ymthe.2024.12.005, 2024.
McCulloch D.E-W., Lopez J.P., Dalla C., Castrén E, Erritzoe D., Frøkjær V., Lundberg J., Preller K., Fisher P., Knudsen G.M.. Knowledge Gaps in Psychedelic Medicalisation: Preclinical and Neuroimaging Mechanisms. Neuroscience Applied, 2024, .
Brunello C., Cannarozzo C., Castrén E. Rethinking the role of TRKB in the action of antidepressants and psychedelics Trends Neurosci, S0166-2236(24)00154-1. doi: 10.1016/j.tins.2024.08.011, 2024.
Madsen C.A., Navarro M.L., Elfving B., Kessing L.V., Castrén E., Mikkelsen J.D. and Knudsen G.M. The effect of antidepressant treatment on blood BDNF levels in depressed patients: A review and methodological recommendations for assessment of BDNF in blood. European Neuropsychopharmacology, 87:35-55. doi: 10.1016/j.euroneuro.2024.06.008, 2024.
2023
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2022
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