Publications

Selected publications

All publications (by year)

Doctoral theses

Master theses

Selected publications

Rouhiainen, A., Kulesskaya, N., Mennesson, M., Misiewicz, Z., Sipilä, T., Sokolowska, E., ... & Hovatta, I. (2019). The bradykinin system in stress and anxiety in humans and mice. Scientific Reports, 9, 19437. DOI: 10.1038/s41598-019-55947-5.

Misiewicz, Z., Iurato, S., Kulesskaya, N., Salminen, L., Rodrigues, L., Maccarrone, G., ... & Hovatta, I. (2019). Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior. PLoS Genetics, 15(9), e1008358. DOI: 10.1371/journal.pgen.1008358.

Mennesson, M., Rydgren, E., Lipina, T., Sokolowska, E., Kulesskaya, N., Morello, F., ... & Hovatta, I. (2019). Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction. Neuropsychopharmacology, 44, 1855–1866. DOI: 10.1038/s41386-019-0344-5. See also Research Highlight.

Laine, M. A., Trontti, K., Misiewicz, Z., Sokolowska, E., Kulesskaya, N., Heikkinen, A., ... Hovatta, I. (2018). Genetic Control of Myelin Plasticity After Chronic Psychosocial Stress. eNeuro, 5(4). DOI: 10.1523/ENEURO.0166-18.2018

Trontti, K., Väänänen, J., Sipilä, T., Greco, D., & Hovatta, I. (2018). Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression. RNA, 24(5), 643-655. DOI: 10.1261/rna.064881.117

Laine, M. A., Sokolowska, E., Dudek, M., Callan, S.-A., Hyytiä, P., & Hovatta, I. (2017). Brain activation induced by chronic psychosocial stress in mice. Scientific Reports, 7, [15061]. DOI: 10.1038/s41598-017-15422-5

Misiewicz, Z., Hiekkalinna, T. S., Paunio, T. M., Varilo, T. T., Terwilliger, J., Partonen, T., & Hovatta, I. M. (2016). A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate. Scientific Reports, 6, [39345]. DOI: 10.1038/srep39345

Hovatta, I. (2015). Genetics: Dynamic Cellular Aging Markers Associated with Major Depression. Current Biology, 25(10), R409-R411. DOI: 10.1016/j.cub.2015.03.036

Rossi, M., Kilpinen, L. H., Muona, M., Surakka, I., Ingle, C., Lahtinen, J., ... Hovatta, I. (2014). Allele-specific regulation of DISC1 expression by miR-135b-5p. European Journal of Human Genetics, 22(6), 840-843. DOI: 10.1038/ejhg.2013.246

Sokolowska, E., & Hovatta, I. (2013). Anxiety genetics-findings from cross-species genome-wide approaches. Biology of mood & anxiety disorders , 3(9). DOI: 10.1186/2045-5380-3-9

Ahola, K., Siren, I., Kivimaki, M., Ripatti, S., Aromaa, A., Lönnqvist, J., & Hovatta, I. (2012). Work-Related Exhaustion and Telomere Length: A Population-Based Study. PLoS One,7(7), Article Number: e40186. DOI: 10.1371/journal.pone.0040186

Donner, J., Sipila, T., Ripatti, S., Kananen, L., Chen, X., Kendler, K. S., ... Hovatta, I. (2012). Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. American journal of medical genetics. Part B, Neuropsychiatric genetics, 159B(3), 316-327. DOI: 10.1002/ajmg.b.32029

Juhila, J., Sipila, T., Icay, K., Nicorici, D., Ellonen, P., Kallio, A., ... Hovatta, I. (2011). MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus. PLoS One, 6(6), e21495. DOI: 10.1371/journal.pone.0021495

Muinos-Gimeno, M., Espinosa-Parrilla, Y., Guidi, M., Kagerbauer, B., Sipilae, T., Maron, E., ... Estivill, X. (2011). Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. Biological Psychiatry, 69(6), 526-533. DOI: 10.1016/j.biopsych.2010.10.010

Kas, M. J., Kahn, R. S., Collier, D. A., Waddington, J. L., Ekelund, J., Porteous, D. J., ... Hovatta, I. (2011). Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man. Science translational medicine, 3(102). DOI: 10.1126/scitranslmed.3002917

Hovatta, I., Juhila, J., & Donner, J. (2010). Oxidative stress in anxiety and comorbid disorders. Neuroscience Research, 68(4), 261-275. DOI: 10.1016/j.neures.2010.08.007

Donner, J., Haapakoski, R., Ezer, S., Melen, E., Pirkola, S., Gratacos, M., ... Hovatta, I. (2010). Assessment of the Neuropeptide S System in Anxiety Disorders. Biological Psychiatry,68(5), 474-483. DOI: 10.1016/j.biopsych.2010.05.039

Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lönnqvist, J., Peltonen, L., ... Hovatta, I. (2010). Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls. PLoS One, 5. DOI: 10.1371/journal.pone.0010826

Sipila, T., Kananen, L., Greco, D., Donner, J., Silander, K., Terwilliger, J. D., ... Hovatta, I. (2010). An Association Analysis of Circadian Genes in Anxiety Disorders. Biological Psychiatry, 67(12), 1163-1170. DOI: doi:10.1016/j.biopsych.2009.12.011

Donner, J., Pirkola, S., Silander, K., Kananen, L., Terwilliger, J., Lönnqvist, J., ... Hovatta, I. (2008). An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Biological Psychiatry, 64(8), 672-680. DOI: 10.1016/j.biopsych.2008.06.002

Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., ... Barlow, C. (2005). Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature, 438, 662-666. DOI:10.1038/nature04250

Zapala, M. A., Hovatta, I., Ellison, J. A., Wodicka, L., Del Rio, J. A., Tennant, R., ... Barlow, C. (2005). Adult mouse brain gene expression patterns bear an embryologic imprint. Proceedings of the National Academy of Sciences of the United States of America, 102, 10357-10362. DOI: 10.1073/pnas.0503357102

All publications (by year)

2019

Forstner, A.J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., ... Hovatta, I., ... , & Schumacher, J. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. Mol Psychiatry. DOI:10.1038/s41380-019-0590-2. Epub ahead of print

Oksanen, M., Hyötyläinen, I., Trontti, K., Rolova, T., Wojciechowski, S., Koskuvi, M., ... , Hovatta, I., ... , & Koistinaho, J. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes. Glia. DOI:10.1002/glia.23741. Epub ahead of print

Sinha, V., Ukkola-Vuoti, L., Ortega-Alonso, A., Torniainen-Holm, M., Therman, S., Tuulio-Henriksson, A., ... , Hovatta, I., ... , & Hennah, W. Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population. Mol Psychiatry. DOI:10.1038/s41380-019-0429-x

Meier, S.M., Trontti, K., Purves, K.L., Damm, T., Grove, J., Laine, M.A., ... Hovatta, I., Mattheisen, M., & Mors, Ole. (2019) Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study. JAMA Psychiatry, 76(9), 924-932. DOI:10.1001/jamapsychiatry.2019.1119

Mantere, O., Trontti, K., García-González, J., Balcells, I., Saarnio, S., Mäntylä, T., ... , Hovatta, I., & Suvisaari, J. Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis. J Psychiatr Res, 109, 18-26. DOI:10.1016/j.jpsychires.2018.11.008

2018

Laine, M. A., Trontti, K., Misiewicz, Z., Sokolowska, E., Kulesskaya, N., Heikkinen, A., ... & Hovatta, I. (2018). Genetic Control of Myelin Plasticity After Chronic Psychosocial Stress. eNeuro, 5(4). DOI: 10.1523/ENEURO.0166-18.2018

Mantere, O., Trontti, K., García-González, J., Balcells, I., Saarnio, S., Mäntylä, T., ... Hovatta, I., Suvisaari, J. (2018). Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis. Journal of Psychiatric Research, 109, 18-26. DOI:10.1016/j.jpsychires.2018.11.008

Gielen, M., Hageman, G. J., Antoniou, E. E., Nordfjall, K., Mangino, M., Balasubramanyam, M., ... Hovatta, I., ... Zeegers, M.P., TELOMAAS group. (2018) Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. The American Journal of Clinical Nutrition, 108(3), 453–475. DOI: 10.1093/ajcn/nqy107

2017

Sindi, S., Ngandu, T., Hovatta, I., Kåreholt, I., Antikainen, R., Hänninen, T., Levälahti, E., ... FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. Journal of Alzheimer's Disease, 59(4), 1459-1470. DOI: 10.3233/JAD-170123

Vincent, J., Hovatta, I., Frissa, S., Goodwin, L., Hotopf, M., Hatch, S. L., ... & Powell, T. R. Assessing the contributions of childhood maltreatment subtypes and depression case-control status on telomere length reveals a specific role of physical neglect. Journal of Affective Disorders, 213, 16-22. DOI: 10.1016/j.jad.2017.01.031

2016

Berglund, K., Reynolds, C. A., Ploner, A., Gerritsen, L., Hovatta, I., Pedersen, N. L., & Hägg, S. (2016). Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk. Aging Clinical and Experimental Research, 8(7), 1398-1415. DOI: 10.18632/aging.100995

2015

Walsh, K. M., Codd, V., Rice, T., Nelson, C. P., Smirnov, I. V., McCoy, L. S., ... Hovatta, I. (2015). Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget, 6(40), 42468-42477. DOI: 10.18632/oncotarget.6468

Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., ... Hietakangas, V. (2015). Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Reports, 13(2), 350-364. DOI: 10.1016/j.celrep.2015.08.081

Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., ... NABEC UKBEC Consortium (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, [8570]. DOI:10.1038/ncomms9570

Hovatta, I. (2015). Genetic influence on CNS gene expression: impact on behavior. ( Reference Module in Biomedical Sciences; Vol. 2015). Elsevier Academic Press. DOI: 10.1016/B978-0-12-801238-3.04601-8

Hovatta, I. (2015). Genetics: Dynamic Cellular Aging Markers Associated with Major Depression. Current Biology, 25(10), R409-R411. DOI: 10.1016/j.cub.2015.03.036

2014

Broer, L., Raschenberger, J., Deelen, J., Mangino, M., Codd, V., Pietilainen, K. H., ... Ladwig, K-H. (2014). Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. European Journal of Epidemiology, 29(9), 629-638. DOI: 10.1007/s10654-014-9940-1

Walsh, K. M., Codd, V., Smirnov, I. V., Rice, T., Decker, P. A., Hansen, H. M., ... Hovatta, I. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46(7), 731-735. DOI: 10.1038/ng.3004

Albrecht, E., Sillanpaa, E., Karrasch, S., Alves, A. C., Codd, V., Hovatta, I., ... Schulz, H. (2014). Telomere length in circulating leukocytes is associated with lung function and disease.European Respiratory Journal, 43(4), 983-992. DOI: 10.1183/09031936.00046213

Joensuu, T., Tegelberg, S., Reinmaa, E., Segerstrale, M., Hakala, P., Pehkonen, H., ... Lehesjoki, A-E. (2014). Gene Expression Alterations in the Cerebellum and Granule Neurons of Cstb(-/-) Mouse Are Associated with Early Synaptic Changes and Inflammation. PLoS One, 9(2), [89321]. DOI: 10.1371/journal.pone.0089321

2013

Nieratschker, V., Lahtinen, J., Meier, S., Strohmaier, J., Frank, J., Heinrich, A., ... Hovatta, I. (2013). Longer telomere length in patients with schizophrenia. Schizophrenia Research,149(1-3), 116-120. DOI: 10.1016/j.schres.2013.06.043

Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., ... CARDIoGRAM Consortium (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45(4), 422-427. DOI: 10.1038/ng.2528

Kouri, V-P., Olkkonen, J., Kaivosoja, E., Ainola, M-M., Juhila, J., Hovatta, I., ... Mandelin, J. (2013). Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level.PLoS One, 8(1), Article Number: e54049. DOI: 10.1371/journal.pone.0054049

Sokolowska, E., & Hovatta, I. (2013). Anxiety genetics-findings from cross-species genome-wide approaches. Biology of mood & anxiety disorders , 3(9). DOI: 10.1186/2045-5380-3-9

2012

Tiainen, A-M. K., Mannisto, S., Blomstedt, P. A., Moltchanova, E., Perala, M-M., Kaartinen, N. E., ... Eriksson, J. G. (2012). Leukocyte telomere length and its relation to food and nutrient intake in an elderly population. European Journal of Clinical Nutrition, 66(12), 1290-1294. DOI: 10.1038/ejcn.2012.143

Kajantie, E., Pietilainen, K. H., Wehkalampi, K., Kananen, L., Räikkönen, K., Rissanen, A., ... Hovatta, I. (2012). No association between body size at birth and leucocyte telomere length in adult life-evidence from three cohort studies. International Journal of Epidemiology, 41(5), 1400-1408. DOI: 10.1093/ije/dys127

Savolainen, K., Räikkönen, K., Kananen, L., Kajantie, E., Hovatta, I., Lahti, M., ... Eriksson, J. G. (2012). History of mental disorders and leukocyte telomere length in late adulthood: The Helsinki Birth Cohort Study (HBCS). Journal of Psychiatric Research, 46(10), 1346-1353. DOI: 10.1016/j.jpsychires.2012.07.005

Hovatta, I., de Mello, V. D. F., Kananen, L., Lindstrom, J., Eriksson, J. G., Ilanne-Parikka, P., ... Uusitupa, M. (2012). Leukocyte Telomere Length in the Finnish Diabetes Prevention Study. PLoS One, 7(4), Article Number: e34948. DOI: 10.1371/journal.pone.0034948

Polvi, A., Linnankivi, T., Kivela, T., Herva, R., Keating, J. P., Makitie, O., ... Lehesjoki, A-E. (2012). Mutations in CTC1, Encoding the CTS Telomere Maintenance Complex Component 1, Cause Cerebroretinal Microangiopathy with Calcifications and Cysts. American Journal of Human Genetics, 90(3), 540-549. DOI: 10.1016/j.ajhg.2012.02.002

2011

Hovatta, I. (2011). Ahdistuneisuuden biologiaa. Suomen lääkärilehti, 66( 36), 2585-90.

Vollert, C., Zagaar, M., Hovatta, I., Taneja, M., Vu, A., Dao, A., ... Salim, S. (2011). Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms. Behavioural Brain Research, 224(2), 233-240. DOI: 10.1016/j.bbr.2011.05.010

Salim, S., Asghar, M., Taneja, M., Hovatta, I., Wu, Y-L., Saha, K., ... Hite, B. (2011). Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Letters,585(9), 1375-1381. DOI: 10.1016/j.febslet.2011.04.023

Salim, S., Asghar, M., Taneja, M., Hovatta, I., Chugh, G., Vollert, C., & Vu, A. (2011). Potential contribution of oxidative stress and inflammation to anxiety and hypertension.Behavioural Brain Research, 1404, 63-71. DOI: 10.1016/j.brainres.2011.06.024

Hovatta, I. (2011). Telomeerien pituus mielenterveyden häiriöissä. Duodecim, 127(15), 1516-1517.

2010

Tyynismaa, H., Carroll, C. J., Raimundo, N., Ahola-Erkkilä, S. T., Wenz, T., Ruhanen, H., ... Suomalainen, A. (2010). Mitochondrial myopathy induces a starvation-like response.Human Molecular Genetics, 19(20), 3948-3958. DOI: 10.1093/hmg/ddq310

Hovatta, I., & Sipilä, T. L. M. (2010). Molecular genetics of anxiety. In Encyclopedia of Life Sciences John Wiley & Sons Ltd.

Eerola, J., Kananen, L., Manninen, K., Hellstrom, O., Tienari, P. J., & Hovatta, I. (2010). No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(11), 1181-1184. DOI: 10.1093/gerona/glq125

Hovatta, I., Juhila, J., & Donner, J. (2010). Oxidative stress in anxiety and comorbid disorders. Neuroscience Research, 68(4), 261-275. DOI: 10.1016/j.neures.2010.08.007

Winn, M. E., Zapala, M. A., Hovatta, I., Risbrough, V. B., Lillie, E., & Schork, N. J. (2010). The effects of globin on microarray-based gene expression analysis of mouse blood.Mammalian Genome, 21(5-6), 268-275. DOI: 10.1007/s00335-010-9261-y

Hovatta, I., Tienari, P., Sajantila, A., & Wartiovaara, A. (2010). Tutkijoiden kouluttajien haasteet. Duodecim, 126(19), 2301-2303.

2009

Hovatta, I. (2009). A functional genomics approach reveals a role for oxidative stress in the regulation of anxiety Neuroscience Research 65 ELSEVIER IRELAND LTD. DOI:10.1016/j.neures.2009.09.1672

Raimundo, N., Vanharanta, S., Aaltonen, L. A., Hovatta, I., & Suomalainen, A. (2009). Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas. Oncogene, 28(9), 1261-1273. DOI: 10.1038/onc.2008.472

Hovatta, I. (2009). Genetic influence on CNS gene expression: impact on behavior. In E. L. R. S. (Ed.), Encyclopedia of neuroscience (pp. 647-654). Amsterdam: Elsevier Academic Press.

Zapala, M. A., Barlow, C., & Hovatta, I. (2009). Molecular anatomy of the mammalian brain. In Encyclopedia of Neuroscience: volume 4 (pp. 913-919). Oxford: Academic Press.

2008

von Schantz, C., Saharinen, J., Kopra, O., Cooper, J. D., Gentile, M., Hovatta, I., ... Jalanko, A. (2008). Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases. BMC Genomics, 9(146), 1-14. DOI: 10.1186/1471-2164-9-146

Hovatta, I., & Paunio, T. (2008). Mieli, keho ja geenit. Duodecim, 124(6), 675-677.

Hovatta, I., & Barlow, C. (2008). Molecular genetics of anxiety in mice and men. Annals of Medicine, 40(2), 92-109. DOI: 10.1080/07853890701747096

Rehnströ, K., Ylisaukko-oja, T., Vanhala, R., Vendt, L. V., Peltonen, L., Hovatta, I., ... Wendt, L. V. (2008). No association between common variants in glyoxalase 1 and autism spectrum disorders. American journal of medical genetics. Part B, Neuropsychiatric genetics, 147B(1), 124-127. DOI: 10.1002/ajmg.b.30582

Hovatta, I., & Mäkelä, T. (2008). Uusia malleja menestyvän tutkijan vakinaistamiselle. Duodecim, 124, 2555-9.

2007

Hovatta, I. (2007). Ahdistuneisuuden genetiikka: spesifisten geenien tunnistus on alkanut : [pääkirjoitus]. Duodecim, 123(14), 1665-1666.

Hovatta, I., Zapala, M. A., Broide, R. S., Schadt, E. E., Schork, N. J., Lockhart, D. J., & Barlow, C. (2007). DNA variation and brain-region specific expression profiles show different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biology, 8(R25). DOI: 10.1186/gb-2007-8-2-r25

2006

Luiro, K. M., Kopra, O., Blom, J. T., Gentile, M., Mitchison, H., Hovatta, I., ... Jalanko, A. (2006). Batten disease (JNCL) is linked to disturbances in mitochondrial, cytoskeletal, and synaptic compartments. Journal of Neuroscience Research, 84(5), 1124-1138. DOI: 10.1002/jnr.21015

von Schantz, C., Heine, C., Kopra, O., Hovatta, I., Peltonen, L., Kyttala, A., & Jalanko, A. (2006). Common Molecular Pathways Underlying Neuronal Ceroid Lipofuscinosis? Molecular Biology of the Cell, 17.

Hovatta, I. (2006). Hiirtä ahdistavat entsyymit. Duodecim, 123, 1665-1666.

2005

Hovatta, I., & Saarela, J. (2005). Affymetrix GeneChip system. In J. Tuimala, & M. M. Laine (Eds.), DNA Microarray Data Analysis (pp. 25-31). CSC - Scientific Computing.

Hovatta, I., & Barlow, C. (2005). Genome to Disease. In S. H. Koslow, & S. Subramaniam (Eds.), Databasing the Brain: Data to Knowledge (pp. 169-190). John Wiley & Sons Ltd.

2004

Arajarvi, R., Haukka, J., Varilo, T., Suokas, J. T., Juvonen, H., Suvisaari, J., ... Lönnqvist, J. (2004). Clinical phenotype of schizophrenia in a Finnish isolate. Schizophrenia Research,67, 195-205. DOI: 10.1016/S0920-9964(03)00007-0

2001

Ekelund, J., Hovatta, I., Parker, A., Paunio, T., Varilo, T., Martin, R., ... Palotie, L. (2001). Chromosome 1 loci in Finnish schizophrenia families. Human Molecular Genetics, 10, 1611-1617.

Paunio, T., Ekelund, J., Varilo, T., Parker, A., Hovatta, I., Turunen, J. A., ... Palotie, L. (2001). Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Human Molecular Genetics, 10, 3037-3048.

Lahdelma, L., Ahokas, A., Andersson, L. C., Suvisaari, J., Hovatta, I., Huttunen, M. O., & Koskimies, S. (2001). Mitchell B. Balter Award. Human leukocyte antigen-A1 predicts a good therapeutic response to clozapine with a low risk of agranulocytosis in patients with schizophrenia. Journal of Clinical Psychopharmacology, 21, 4-7. DOI: 10.1097/00004714-200102000-00002

2000

Virolainen, E., Wessman, M., Hovatta, I., Niemi, K. M., Ignatius, J., Kere, J., ... Palotie, A. (2000). Assignment of a novel locus for autosomal recessive congenital ichthyosis chromosome 19p13.1-p13.2. American Journal of Human Genetics, 2000(66), 1132-1137. DOI: 10.1086/302813

Kaunisto, M., Hamalainen, E., Kallela, M., Harno, H., Marttila, P., Hovatta, I., ... Wessman, M. (2000). Exclusion of CACNA1A and KCNN1 as candidate genes for migraine in three 19p13-linked Finnish families. American Journal of Human Genetics 67 Cell Press.

Varilo, T., Laan, M., Hovatta, I., Wiebe, V., Terwilliger, J. D., & Palotie, L. (2000). Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo.European Journal of Human Genetics, 8, 604-612. DOI: 10.1038/sj.ejhg.5200482

1999

Hovatta, I., Varilo, T., Suvisaari, J., Terwilliger, J. D., Ollikainen, V., Arajarvi, R., ... Palotie, L. (1999). A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. American Journal of Human Genetics, 65, 1114-1124. DOI: 10.1086/302567

Kaunisto, M., Kallela, M., Marttila, P., Farkkila, M., Havanka, H., Hamalainen, E., ... Wessman, M. (1999). Genetic studies on Finnish families with familial hemiplegic migraine.American Journal of Human Genetics 65 Cell Press.

1998

Pekkarinen, P., Hovatta, I., Hakola, P., Jarvi, O., Kestila, M., Lenkkeri, U., ... Peltonen, L. (1998). Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13. American Journal of Human Genetics, 62, 362-372.

1994

Hovatta, I., Kallela, K. M. J., Färkkilä, M., & Peltonen, L. (1994). Familial migraine: exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p.Genomics, 1994(23), 707-709. DOI: 10.1006/geno.1994.1563

Hovatta, I., Seppälä, J., Pekkarinen, P., Tanskanen, A. J., Lönnqvist, J., & Palotie, L. (1994). Linkage analysis in two schizophrenic families originating from a restricted subpopulation of Finland. Psychiatric Genetics, 4(3), 143-152.

Doctoral theses

2019

Marie Mennesson: Kainate receptor auxiliary subunits NETO1 and NETO2 in anxiety and fear-related behaviors, University of Helsiki, Finland.

Zuzanna Misiewicz: What Makes Us Anxious: A Cross-Species Multi-omics Approach to the Biological Basis of Anxiety Disorders, University of Helsinki, Finland. Approved with distinction.

2012

Jonas Donner: Candidate gene studies in human anxiety disorders, University of Helsinki, Finland. Approved with distinction.

2010

Helena Kilpinen (together with Leena Peltonen-Palotie): Genetic mechanisms underlying autism spectrum disorders, University of Helsinki, Finland. Approved with distinction.

Master theses

2018

Emilie Rydgren: The effect of NETO2 on synaptosomal kainate receptor subunit levels in fear-related brain regions, University of Helsinki, Finland

Joni Tiilikainen: Micro-RNAs in chronic stress, University of Helsinki, Finland

Aino Heikkinen: Number of oligodendrocytes and size of the myelinated area in mice exposed to chronic psychosocial stress, University of Helsinki, Finland

2017

Laura Salminen: The effect of homocysteine on telomere length, University of Helsinki, Finland

2016

Lea Urpa: Mouse strain-specific differences in transposable element expression following psychosocial stress, University of Helsinki, Finland

Mikaela Laine: Resilience to psychosocial stress associates with altered myelination in the mouse cortex, University of Helsinki, Finland

2014

Judit Garcia Gonzalez: Blood cell gene expression analysis of CDCL1 and TGFA in first episode psychosis patients, Polytechnic University of Valencia, Spain

2011

Katherine Icay: Identifying putative microRNA-regulated biological networks with bioinformatics tools, University of Helsinki, Finland

Kaisa Manninen: The role of Gsr in the regulation of anxiety-like behavior, University of Helsinki, Finland

2009

Pia Rasinkangas: Haem biosynthesis in anxiety: gene expression analysis and lentivirus vector construction for functional studies, University of Oulu, Finland

2008

Tessa Sipilä: Circadian clock-related genes as candidate genes for anxiety disorders, University of Jyväskylä, Finland

2007

Jonas Donner: A genetic analysis of thirteen anxiety candidate genes, University of Helsinki, Finland

Neurogenomics laboratory

Neurogenomics laboratory

Publications

Selected publications

All publications (by year)

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2001

2000

1999

1998

1994

Doctoral theses

2019

2012

2010

Master theses

2018

2017

2016

2014

2011

2009

2008

2007