.
Publications
Rouhiainen, A., Kulesskaya, N., Mennesson, M., Misiewicz, Z., Sipilä, T., Sokolowska, E., ... & Hovatta, I. (2019). The bradykinin system in stress and anxiety in humans and mice. Scientific Reports, 9, 19437. DOI: 10.1038/s41598-019-55947-5.
Misiewicz, Z., Iurato, S., Kulesskaya, N., Salminen, L., Rodrigues, L., Maccarrone, G., ... & Hovatta, I. (2019). Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior. PLoS Genetics, 15(9), e1008358. DOI: 10.1371/journal.pgen.1008358.
Mennesson, M., Rydgren, E., Lipina, T., Sokolowska, E., Kulesskaya, N., Morello, F., ... & Hovatta, I. (2019). Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction. Neuropsychopharmacology, 44, 1855–1866. DOI: 10.1038/s41386-019-0344-5. See also Research Highlight.
Laine, M. A., Trontti, K., Misiewicz, Z., Sokolowska, E., Kulesskaya, N., Heikkinen, A., ... Hovatta, I. (2018). Genetic Control of Myelin Plasticity After Chronic Psychosocial Stress. eNeuro, 5(4). DOI: 10.1523/ENEURO.0166-18.2018
Trontti, K., Väänänen, J., Sipilä, T., Greco, D., & Hovatta, I. (2018). Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression. RNA, 24(5), 643-655. DOI: 10.1261/rna.064881.117
Laine, M. A., Sokolowska, E., Dudek, M., Callan, S.-A., Hyytiä, P., & Hovatta, I. (2017). Brain activation induced by chronic psychosocial stress in mice. Scientific Reports, 7, [15061]. DOI: 10.1038/s41598-017-15422-5
Misiewicz, Z., Hiekkalinna, T. S., Paunio, T. M., Varilo, T. T., Terwilliger, J., Partonen, T., & Hovatta, I. M. (2016). A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate. Scientific Reports, 6, [39345]. DOI: 10.1038/srep39345
Hovatta, I. (2015). Genetics: Dynamic Cellular Aging Markers Associated with Major Depression. Current Biology, 25(10), R409-R411. DOI: 10.1016/j.cub.2015.03.036
Rossi, M., Kilpinen, L. H., Muona, M., Surakka, I., Ingle, C., Lahtinen, J., ... Hovatta, I. (2014). Allele-specific regulation of DISC1 expression by miR-135b-5p. European Journal of Human Genetics, 22(6), 840-843. DOI: 10.1038/ejhg.2013.246
Sokolowska, E., & Hovatta, I. (2013). Anxiety genetics-findings from cross-species genome-wide approaches. Biology of mood & anxiety disorders , 3(9). DOI: 10.1186/2045-5380-3-9
Ahola, K., Siren, I., Kivimaki, M., Ripatti, S., Aromaa, A., Lönnqvist, J., & Hovatta, I. (2012). Work-Related Exhaustion and Telomere Length: A Population-Based Study. PLoS One,7(7), Article Number: e40186. DOI: 10.1371/journal.pone.0040186
Donner, J., Sipila, T., Ripatti, S., Kananen, L., Chen, X., Kendler, K. S., ... Hovatta, I. (2012). Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. American journal of medical genetics. Part B, Neuropsychiatric genetics, 159B(3), 316-327. DOI: 10.1002/ajmg.b.32029
Juhila, J., Sipila, T., Icay, K., Nicorici, D., Ellonen, P., Kallio, A., ... Hovatta, I. (2011). MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus. PLoS One, 6(6), e21495. DOI: 10.1371/journal.pone.0021495
Muinos-Gimeno, M., Espinosa-Parrilla, Y., Guidi, M., Kagerbauer, B., Sipilae, T., Maron, E., ... Estivill, X. (2011). Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. Biological Psychiatry, 69(6), 526-533. DOI: 10.1016/j.biopsych.2010.10.010
Kas, M. J., Kahn, R. S., Collier, D. A., Waddington, J. L., Ekelund, J., Porteous, D. J., ... Hovatta, I. (2011). Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man. Science translational medicine, 3(102). DOI: 10.1126/scitranslmed.3002917
Hovatta, I., Juhila, J., & Donner, J. (2010). Oxidative stress in anxiety and comorbid disorders. Neuroscience Research, 68(4), 261-275. DOI: 10.1016/j.neures.2010.08.007
Donner, J., Haapakoski, R., Ezer, S., Melen, E., Pirkola, S., Gratacos, M., ... Hovatta, I. (2010). Assessment of the Neuropeptide S System in Anxiety Disorders. Biological Psychiatry,68(5), 474-483. DOI: 10.1016/j.biopsych.2010.05.039
Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lönnqvist, J., Peltonen, L., ... Hovatta, I. (2010). Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls. PLoS One, 5. DOI: 10.1371/journal.pone.0010826
Sipila, T., Kananen, L., Greco, D., Donner, J., Silander, K., Terwilliger, J. D., ... Hovatta, I. (2010). An Association Analysis of Circadian Genes in Anxiety Disorders. Biological Psychiatry, 67(12), 1163-1170. DOI: doi:10.1016/j.biopsych.2009.12.011
Donner, J., Pirkola, S., Silander, K., Kananen, L., Terwilliger, J., Lönnqvist, J., ... Hovatta, I. (2008). An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Biological Psychiatry, 64(8), 672-680. DOI: 10.1016/j.biopsych.2008.06.002
Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., ... Barlow, C. (2005). Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature, 438, 662-666. DOI:10.1038/nature04250
Zapala, M. A., Hovatta, I., Ellison, J. A., Wodicka, L., Del Rio, J. A., Tennant, R., ... Barlow, C. (2005). Adult mouse brain gene expression patterns bear an embryologic imprint. Proceedings of the National Academy of Sciences of the United States of America, 102, 10357-10362. DOI: 10.1073/pnas.0503357102
2020
Mennesson M, Orav E, Gigliotta A, ... & Hovatta, I. Kainate Receptor Auxiliary Subunit NETO2-Related Cued Fear Conditioning Impairments Associate with Defects in Amygdala Development and Excitability. eNeuro. 2020;7(4):ENEURO.0541-19.2020.
DOI:10.1523/ENEURO.0541-19.2020
Oksanen M, Hyötyläinen I, Trontti K, ... & Hovatta, I. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes. Glia. 2020;68(3):589-599.
DOI:10.1002/glia.23741
Li C., Stoma S., Lotta LA., Warner S., Albrecht E., Allione A., ... Hovatta I., ..., & Codd V. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020;106(3):389-404. DOI:10.1016/j.ajhg.2020.02.006
2019
Rouhiainen, A., Kulesskaya, N., Mennesson, M., Misiewicz, Z., Sipilä, T., Sokolowska, E., ... & Hovatta, I. (2019). The bradykinin system in stress and anxiety in humans and mice. Scientific Reports, 9, 19437. DOI: 10.1038/s41598-019-55947-5.
Forstner, A.J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., ... Hovatta, I., ... , & Schumacher, J. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. Mol Psychiatry. DOI:10.1038/s41380-019-0590-2. Epub ahead of print
Oksanen, M., Hyötyläinen, I., Trontti, K., Rolova, T., Wojciechowski, S., Koskuvi, M., ... , Hovatta, I., ... , & Koistinaho, J. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes. Glia. DOI:10.1002/glia.23741. Epub ahead of print
Misiewicz, Z., Iurato, S., Kulesskaya, N., Salminen, L., Rodrigues, L., Maccarrone, G., ... & Hovatta, I. (2019). Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior. PLoS Genetics, 15(9), e1008358. DOI: 10.1371/journal.pgen.1008358
Sinha, V., Ukkola-Vuoti, L., Ortega-Alonso, A., Torniainen-Holm, M., Therman, S., Tuulio-Henriksson, A., ... , Hovatta, I., ... , & Hennah, W. Variants in regulatory elements of PDE4D associate with major mental illness in the Finnish population. Mol Psychiatry. DOI:10.1038/s41380-019-0429-x
Meier, S.M., Trontti, K., Purves, K.L., Damm, T., Grove, J., Laine, M.A., ... Hovatta, I., Mattheisen, M., & Mors, Ole. (2019) Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study. JAMA Psychiatry, 76(9), 924-932. DOI:10.1001/jamapsychiatry.2019.1119
Mantere, O., Trontti, K., García-González, J., Balcells, I., Saarnio, S., Mäntylä, T., ... , Hovatta, I., & Suvisaari, J. Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis. J Psychiatr Res, 109, 18-26. DOI:10.1016/j.jpsychires.2018.11.008
Mennesson, M., Rydgren, E., Lipina, T., Sokolowska, E., Kulesskaya, N., Morello, F., ... & Hovatta, I. (2019). Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction. Neuropsychopharmacology, 44, 1855–1866. DOI: 10.1038/s41386-019-0344-5
2018
Laine, M. A., Trontti, K., Misiewicz, Z., Sokolowska, E., Kulesskaya, N., Heikkinen, A., ... & Hovatta, I. (2018). Genetic Control of Myelin Plasticity After Chronic Psychosocial Stress. eNeuro, 5(4). DOI: 10.1523/ENEURO.0166-18.2018
Trontti, K., Väänänen, J., Sipilä, T., Greco, D., & Hovatta, I. (2018). Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression. RNA, 24(5), 643-655. DOI: 10.1261/rna.064881.117
Mantere, O., Trontti, K., García-González, J., Balcells, I., Saarnio, S., Mäntylä, T., ... Hovatta, I., Suvisaari, J. (2018). Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis. Journal of Psychiatric Research, 109, 18-26. DOI:10.1016/j.jpsychires.2018.11.008
Gielen, M., Hageman, G. J., Antoniou, E. E., Nordfjall, K., Mangino, M., Balasubramanyam, M., ... Hovatta, I., ... Zeegers, M.P., TELOMAAS group. (2018) Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. The American Journal of Clinical Nutrition, 108(3), 453–475. DOI: 10.1093/ajcn/nqy107
2017
Laine, M. A., Sokolowska, E., Dudek, M., Callan, S.-A., Hyytiä, P., & Hovatta, I. (2017). Brain activation induced by chronic psychosocial stress in mice. Scientific Reports, 7, [15061]. DOI: 10.1038/s41598-017-15422-5
Sindi, S., Ngandu, T., Hovatta, I., Kåreholt, I., Antikainen, R., Hänninen, T., Levälahti, E., ... FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. Journal of Alzheimer's Disease, 59(4), 1459-1470. DOI: 10.3233/JAD-170123
Vincent, J., Hovatta, I., Frissa, S., Goodwin, L., Hotopf, M., Hatch, S. L., ... & Powell, T. R. Assessing the contributions of childhood maltreatment subtypes and depression case-control status on telomere length reveals a specific role of physical neglect. Journal of Affective Disorders, 213, 16-22. DOI: 10.1016/j.jad.2017.01.031
2016
Misiewicz, Z., Hiekkalinna, T. S., Paunio, T. M., Varilo, T. T., Terwilliger, J., Partonen, T., & Hovatta, I. M. (2016). A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate. Scientific Reports, 6, [39345]. DOI: 10.1038/srep39345
Berglund, K., Reynolds, C. A., Ploner, A., Gerritsen, L., Hovatta, I., Pedersen, N. L., & Hägg, S. (2016). Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk. Aging Clinical and Experimental Research, 8(7), 1398-1415. DOI: 10.18632/aging.100995
2015
Walsh, K. M., Codd, V., Rice, T., Nelson, C. P., Smirnov, I. V., McCoy, L. S., ... Hovatta, I. (2015). Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget, 6(40), 42468-42477. DOI: 10.18632/oncotarget.6468
Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., ... Hietakangas, V. (2015). Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Reports, 13(2), 350-364. DOI: 10.1016/j.celrep.2015.08.081
Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., ... NABEC UKBEC Consortium (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, [8570]. DOI:10.1038/ncomms9570
Hovatta, I. (2015). Genetic influence on CNS gene expression: impact on behavior. ( Reference Module in Biomedical Sciences; Vol. 2015). Elsevier Academic Press. DOI: 10.1016/B978-0-12-801238-3.04601-8
Hovatta, I. (2015). Genetics: Dynamic Cellular Aging Markers Associated with Major Depression. Current Biology, 25(10), R409-R411. DOI: 10.1016/j.cub.2015.03.036
2014
Broer, L., Raschenberger, J., Deelen, J., Mangino, M., Codd, V., Pietilainen, K. H., ... Ladwig, K-H. (2014). Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. European Journal of Epidemiology, 29(9), 629-638. DOI: 10.1007/s10654-014-9940-1
Walsh, K. M., Codd, V., Smirnov, I. V., Rice, T., Decker, P. A., Hansen, H. M., ... Hovatta, I. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46(7), 731-735. DOI: 10.1038/ng.3004
Rossi, M., Kilpinen, L. H., Muona, M., Surakka, I., Ingle, C., Lahtinen, J., ... Hovatta, I. (2014). Allele-specific regulation of DISC1 expression by miR-135b-5p. European Journal of Human Genetics, 22(6), 840-843. DOI: 10.1038/ejhg.2013.246
Albrecht, E., Sillanpaa, E., Karrasch, S., Alves, A. C., Codd, V., Hovatta, I., ... Schulz, H. (2014). Telomere length in circulating leukocytes is associated with lung function and disease.European Respiratory Journal, 43(4), 983-992. DOI: 10.1183/09031936.00046213
Joensuu, T., Tegelberg, S., Reinmaa, E., Segerstrale, M., Hakala, P., Pehkonen, H., ... Lehesjoki, A-E. (2014). Gene Expression Alterations in the Cerebellum and Granule Neurons of Cstb(-/-) Mouse Are Associated with Early Synaptic Changes and Inflammation. PLoS One, 9(2), [89321]. DOI: 10.1371/journal.pone.0089321
2013
Nieratschker, V., Lahtinen, J., Meier, S., Strohmaier, J., Frank, J., Heinrich, A., ... Hovatta, I. (2013). Longer telomere length in patients with schizophrenia. Schizophrenia Research,149(1-3), 116-120. DOI: 10.1016/j.schres.2013.06.043
Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., ... CARDIoGRAM Consortium (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45(4), 422-427. DOI: 10.1038/ng.2528
Kouri, V-P., Olkkonen, J., Kaivosoja, E., Ainola, M-M., Juhila, J., Hovatta, I., ... Mandelin, J. (2013). Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level.PLoS One, 8(1), Article Number: e54049. DOI: 10.1371/journal.pone.0054049
Sokolowska, E., & Hovatta, I. (2013). Anxiety genetics-findings from cross-species genome-wide approaches. Biology of mood & anxiety disorders , 3(9). DOI: 10.1186/2045-5380-3-9
2012
Tiainen, A-M. K., Mannisto, S., Blomstedt, P. A., Moltchanova, E., Perala, M-M., Kaartinen, N. E., ... Eriksson, J. G. (2012). Leukocyte telomere length and its relation to food and nutrient intake in an elderly population. European Journal of Clinical Nutrition, 66(12), 1290-1294. DOI: 10.1038/ejcn.2012.143
Kajantie, E., Pietilainen, K. H., Wehkalampi, K., Kananen, L., Räikkönen, K., Rissanen, A., ... Hovatta, I. (2012). No association between body size at birth and leucocyte telomere length in adult life-evidence from three cohort studies. International Journal of Epidemiology, 41(5), 1400-1408. DOI: 10.1093/ije/dys127
Savolainen, K., Räikkönen, K., Kananen, L., Kajantie, E., Hovatta, I., Lahti, M., ... Eriksson, J. G. (2012). History of mental disorders and leukocyte telomere length in late adulthood: The Helsinki Birth Cohort Study (HBCS). Journal of Psychiatric Research, 46(10), 1346-1353. DOI: 10.1016/j.jpsychires.2012.07.005
Hovatta, I., de Mello, V. D. F., Kananen, L., Lindstrom, J., Eriksson, J. G., Ilanne-Parikka, P., ... Uusitupa, M. (2012). Leukocyte Telomere Length in the Finnish Diabetes Prevention Study. PLoS One, 7(4), Article Number: e34948. DOI: 10.1371/journal.pone.0034948
Polvi, A., Linnankivi, T., Kivela, T., Herva, R., Keating, J. P., Makitie, O., ... Lehesjoki, A-E. (2012). Mutations in CTC1, Encoding the CTS Telomere Maintenance Complex Component 1, Cause Cerebroretinal Microangiopathy with Calcifications and Cysts. American Journal of Human Genetics, 90(3), 540-549. DOI: 10.1016/j.ajhg.2012.02.002
Donner, J., Sipila, T., Ripatti, S., Kananen, L., Chen, X., Kendler, K. S., ... Hovatta, I. (2012). Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. American journal of medical genetics. Part B, Neuropsychiatric genetics, 159B(3), 316-327. DOI: 10.1002/ajmg.b.32029
Ahola, K., Siren, I., Kivimaki, M., Ripatti, S., Aromaa, A., Lönnqvist, J., & Hovatta, I. (2012). Work-Related Exhaustion and Telomere Length: A Population-Based Study. PLoS One,7(7), Article Number: e40186. DOI: 10.1371/journal.pone.0040186
2011
Hovatta, I. (2011). Ahdistuneisuuden biologiaa. Suomen lääkärilehti, 66( 36), 2585-90.
Vollert, C., Zagaar, M., Hovatta, I., Taneja, M., Vu, A., Dao, A., ... Salim, S. (2011). Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms. Behavioural Brain Research, 224(2), 233-240. DOI: 10.1016/j.bbr.2011.05.010
Muinos-Gimeno, M., Espinosa-Parrilla, Y., Guidi, M., Kagerbauer, B., Sipilae, T., Maron, E., ... Estivill, X. (2011). Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. Biological Psychiatry, 69(6), 526-533. DOI: 10.1016/j.biopsych.2010.10.010
Juhila, J., Sipila, T., Icay, K., Nicorici, D., Ellonen, P., Kallio, A., ... Hovatta, I. (2011). MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus. PLoS One, 6(6), e21495. DOI: 10.1371/journal.pone.0021495
Salim, S., Asghar, M., Taneja, M., Hovatta, I., Wu, Y-L., Saha, K., ... Hite, B. (2011). Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Letters,585(9), 1375-1381. DOI: 10.1016/j.febslet.2011.04.023
Salim, S., Asghar, M., Taneja, M., Hovatta, I., Chugh, G., Vollert, C., & Vu, A. (2011). Potential contribution of oxidative stress and inflammation to anxiety and hypertension.Behavioural Brain Research, 1404, 63-71. DOI: 10.1016/j.brainres.2011.06.024
Hovatta, I. (2011). Telomeerien pituus mielenterveyden häiriöissä. Duodecim, 127(15), 1516-1517.
Kas, M. J., Kahn, R. S., Collier, D. A., Waddington, J. L., Ekelund, J., Porteous, D. J., ... Hovatta, I. (2011). Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man. Science translational medicine, 3(102). DOI: 10.1126/scitranslmed.3002917
2010
Sipila, T., Kananen, L., Greco, D., Donner, J., Silander, K., Terwilliger, J. D., ... Hovatta, I. (2010). An Association Analysis of Circadian Genes in Anxiety Disorders. Biological Psychiatry, 67(12), 1163-1170. DOI: doi:10.1016/j.biopsych.2009.12.011
Donner, J., Haapakoski, R., Ezer, S., Melen, E., Pirkola, S., Gratacos, M., ... Hovatta, I. (2010). Assessment of the Neuropeptide S System in Anxiety Disorders. Biological Psychiatry,68(5), 474-483. DOI: 10.1016/j.biopsych.2010.05.039
Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lönnqvist, J., Peltonen, L., ... Hovatta, I. (2010). Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls. PLoS One, 5. DOI: 10.1371/journal.pone.0010826
Tyynismaa, H., Carroll, C. J., Raimundo, N., Ahola-Erkkilä, S. T., Wenz, T., Ruhanen, H., ... Suomalainen, A. (2010). Mitochondrial myopathy induces a starvation-like response.Human Molecular Genetics, 19(20), 3948-3958. DOI: 10.1093/hmg/ddq310
Hovatta, I., & Sipilä, T. L. M. (2010). Molecular genetics of anxiety. In Encyclopedia of Life Sciences John Wiley & Sons Ltd.
Eerola, J., Kananen, L., Manninen, K., Hellstrom, O., Tienari, P. J., & Hovatta, I. (2010). No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(11), 1181-1184. DOI: 10.1093/gerona/glq125
Hovatta, I., Juhila, J., & Donner, J. (2010). Oxidative stress in anxiety and comorbid disorders. Neuroscience Research, 68(4), 261-275. DOI: 10.1016/j.neures.2010.08.007
Winn, M. E., Zapala, M. A., Hovatta, I., Risbrough, V. B., Lillie, E., & Schork, N. J. (2010). The effects of globin on microarray-based gene expression analysis of mouse blood.Mammalian Genome, 21(5-6), 268-275. DOI: 10.1007/s00335-010-9261-y
Hovatta, I., Tienari, P., Sajantila, A., & Wartiovaara, A. (2010). Tutkijoiden kouluttajien haasteet. Duodecim, 126(19), 2301-2303.
2009
Hovatta, I. (2009). A functional genomics approach reveals a role for oxidative stress in the regulation of anxiety Neuroscience Research 65 ELSEVIER IRELAND LTD. DOI:10.1016/j.neures.2009.09.1672
Raimundo, N., Vanharanta, S., Aaltonen, L. A., Hovatta, I., & Suomalainen, A. (2009). Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas. Oncogene, 28(9), 1261-1273. DOI: 10.1038/onc.2008.472
Hovatta, I. (2009). Genetic influence on CNS gene expression: impact on behavior. In E. L. R. S. (Ed.), Encyclopedia of neuroscience (pp. 647-654). Amsterdam: Elsevier Academic Press.
Zapala, M. A., Barlow, C., & Hovatta, I. (2009). Molecular anatomy of the mammalian brain. In Encyclopedia of Neuroscience: volume 4 (pp. 913-919). Oxford: Academic Press.
2008
Donner, J., Pirkola, S., Silander, K., Kananen, L., Terwilliger, J., Lönnqvist, J., ... Hovatta, I. (2008). An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Biological Psychiatry, 64(8), 672-680. DOI: 10.1016/j.biopsych.2008.06.002
von Schantz, C., Saharinen, J., Kopra, O., Cooper, J. D., Gentile, M., Hovatta, I., ... Jalanko, A. (2008). Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases. BMC Genomics, 9(146), 1-14. DOI: 10.1186/1471-2164-9-146
Hovatta, I., & Paunio, T. (2008). Mieli, keho ja geenit. Duodecim, 124(6), 675-677.
Hovatta, I., & Barlow, C. (2008). Molecular genetics of anxiety in mice and men. Annals of Medicine, 40(2), 92-109. DOI: 10.1080/07853890701747096
Rehnströ, K., Ylisaukko-oja, T., Vanhala, R., Vendt, L. V., Peltonen, L., Hovatta, I., ... Wendt, L. V. (2008). No association between common variants in glyoxalase 1 and autism spectrum disorders. American journal of medical genetics. Part B, Neuropsychiatric genetics, 147B(1), 124-127. DOI: 10.1002/ajmg.b.30582
Hovatta, I., & Mäkelä, T. (2008). Uusia malleja menestyvän tutkijan vakinaistamiselle. Duodecim, 124, 2555-9.
2007
Hovatta, I. (2007). Ahdistuneisuuden genetiikka: spesifisten geenien tunnistus on alkanut : [pääkirjoitus]. Duodecim, 123(14), 1665-1666.
Hovatta, I., Zapala, M. A., Broide, R. S., Schadt, E. E., Schork, N. J., Lockhart, D. J., & Barlow, C. (2007). DNA variation and brain-region specific expression profiles show different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biology, 8(R25). DOI: 10.1186/gb-2007-8-2-r25
2006
Luiro, K. M., Kopra, O., Blom, J. T., Gentile, M., Mitchison, H., Hovatta, I., ... Jalanko, A. (2006). Batten disease (JNCL) is linked to disturbances in mitochondrial, cytoskeletal, and synaptic compartments. Journal of Neuroscience Research, 84(5), 1124-1138. DOI: 10.1002/jnr.21015
von Schantz, C., Heine, C., Kopra, O., Hovatta, I., Peltonen, L., Kyttala, A., & Jalanko, A. (2006). Common Molecular Pathways Underlying Neuronal Ceroid Lipofuscinosis? Molecular Biology of the Cell, 17.
Hovatta, I. (2006). Hiirtä ahdistavat entsyymit. Duodecim, 123, 1665-1666.
2005
Zapala, M. A., Hovatta, I., Ellison, J. A., Wodicka, L., Del Rio, J. A., Tennant, R., ... Barlow, C. (2005). Adult mouse brain gene expression patterns bear an embryologic imprint. Proceedings of the National Academy of Sciences of the United States of America, 102, 10357-10362. DOI: 10.1073/pnas.0503357102
Hovatta, I., & Saarela, J. (2005). Affymetrix GeneChip system. In J. Tuimala, & M. M. Laine (Eds.), DNA Microarray Data Analysis (pp. 25-31). CSC - Scientific Computing.
Hovatta, I., & Barlow, C. (2005). Genome to Disease. In S. H. Koslow, & S. Subramaniam (Eds.), Databasing the Brain: Data to Knowledge (pp. 169-190). John Wiley & Sons Ltd.
Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., ... Barlow, C. (2005). Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature, 438, 662-666. DOI:10.1038/nature04250
2004
Arajarvi, R., Haukka, J., Varilo, T., Suokas, J. T., Juvonen, H., Suvisaari, J., ... Lönnqvist, J. (2004). Clinical phenotype of schizophrenia in a Finnish isolate. Schizophrenia Research,67, 195-205. DOI: 10.1016/S0920-9964(03)00007-0
2001
Ekelund, J., Hovatta, I., Parker, A., Paunio, T., Varilo, T., Martin, R., ... Palotie, L. (2001). Chromosome 1 loci in Finnish schizophrenia families. Human Molecular Genetics, 10, 1611-1617.
Paunio, T., Ekelund, J., Varilo, T., Parker, A., Hovatta, I., Turunen, J. A., ... Palotie, L. (2001). Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Human Molecular Genetics, 10, 3037-3048.
Lahdelma, L., Ahokas, A., Andersson, L. C., Suvisaari, J., Hovatta, I., Huttunen, M. O., & Koskimies, S. (2001). Mitchell B. Balter Award. Human leukocyte antigen-A1 predicts a good therapeutic response to clozapine with a low risk of agranulocytosis in patients with schizophrenia. Journal of Clinical Psychopharmacology, 21, 4-7. DOI: 10.1097/00004714-200102000-00002
2000
Virolainen, E., Wessman, M., Hovatta, I., Niemi, K. M., Ignatius, J., Kere, J., ... Palotie, A. (2000). Assignment of a novel locus for autosomal recessive congenital ichthyosis chromosome 19p13.1-p13.2. American Journal of Human Genetics, 2000(66), 1132-1137. DOI: 10.1086/302813
Kaunisto, M., Hamalainen, E., Kallela, M., Harno, H., Marttila, P., Hovatta, I., ... Wessman, M. (2000). Exclusion of CACNA1A and KCNN1 as candidate genes for migraine in three 19p13-linked Finnish families. American Journal of Human Genetics 67 Cell Press.
Varilo, T., Laan, M., Hovatta, I., Wiebe, V., Terwilliger, J. D., & Palotie, L. (2000). Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo.European Journal of Human Genetics, 8, 604-612. DOI: 10.1038/sj.ejhg.5200482
1999
Hovatta, I., Varilo, T., Suvisaari, J., Terwilliger, J. D., Ollikainen, V., Arajarvi, R., ... Palotie, L. (1999). A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. American Journal of Human Genetics, 65, 1114-1124. DOI: 10.1086/302567
Kaunisto, M., Kallela, M., Marttila, P., Farkkila, M., Havanka, H., Hamalainen, E., ... Wessman, M. (1999). Genetic studies on Finnish families with familial hemiplegic migraine.American Journal of Human Genetics 65 Cell Press.
1998
Pekkarinen, P., Hovatta, I., Hakola, P., Jarvi, O., Kestila, M., Lenkkeri, U., ... Peltonen, L. (1998). Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13. American Journal of Human Genetics, 62, 362-372.
1994
Hovatta, I., Kallela, K. M. J., Färkkilä, M., & Peltonen, L. (1994). Familial migraine: exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p.Genomics, 1994(23), 707-709. DOI: 10.1006/geno.1994.1563
Hovatta, I., Seppälä, J., Pekkarinen, P., Tanskanen, A. J., Lönnqvist, J., & Palotie, L. (1994). Linkage analysis in two schizophrenic families originating from a restricted subpopulation of Finland. Psychiatric Genetics, 4(3), 143-152.
2019
Marie Mennesson: Kainate receptor auxiliary subunits NETO1 and NETO2 in anxiety and fear-related behaviors, University of Helsiki, Finland.
Zuzanna Misiewicz: What Makes Us Anxious: A Cross-Species Multi-omics Approach to the Biological Basis of Anxiety Disorders, University of Helsinki, Finland. Approved with distinction.
2012
Jonas Donner: Candidate gene studies in human anxiety disorders, University of Helsinki, Finland. Approved with distinction.
2010
Helena Kilpinen (together with Leena Peltonen-Palotie): Genetic mechanisms underlying autism spectrum disorders, University of Helsinki, Finland. Approved with distinction.
2018
Emilie Rydgren: The effect of NETO2 on synaptosomal kainate receptor subunit levels in fear-related brain regions, University of Helsinki, Finland
Joni Tiilikainen: Micro-RNAs in chronic stress, University of Helsinki, Finland
Aino Heikkinen: Number of oligodendrocytes and size of the myelinated area in mice exposed to chronic psychosocial stress, University of Helsinki, Finland
2017
Laura Salminen: The effect of homocysteine on telomere length, University of Helsinki, Finland
2016
Lea Urpa: Mouse strain-specific differences in transposable element expression following psychosocial stress, University of Helsinki, Finland
Mikaela Laine: Resilience to psychosocial stress associates with altered myelination in the mouse cortex, University of Helsinki, Finland
2014
Judit Garcia Gonzalez: Blood cell gene expression analysis of CDCL1 and TGFA in first episode psychosis patients, Polytechnic University of Valencia, Spain
2011
Katherine Icay: Identifying putative microRNA-regulated biological networks with bioinformatics tools, University of Helsinki, Finland
Kaisa Manninen: The role of Gsr in the regulation of anxiety-like behavior, University of Helsinki, Finland
2009
Pia Rasinkangas: Haem biosynthesis in anxiety: gene expression analysis and lentivirus vector construction for functional studies, University of Oulu, Finland
2008
Tessa Sipilä: Circadian clock-related genes as candidate genes for anxiety disorders, University of Jyväskylä, Finland
2007
Jonas Donner: A genetic analysis of thirteen anxiety candidate genes, University of Helsinki, Finland