Publications

2023

• Gigliotta A., …, Hovatta I. Genetic background modulates the effect of glucocorticoids on proliferation, differentiation and myelin formation of oligodendrocyte lineage cells. European Journal of Neuroscience. 2024. 59(9):2276-2292. https://doi.org/10.1111/ejn.16285

   

• Pesonen A., Koskinen M.-K., …, Hovatta I. The effect of REM-sleep disruption on affective processing: A systematic review of human and animal experimental studies. Neuroscience & Biobehavioral Reviews. 2024. 162:105714. https://doi.org/10.1016/j.neubiorev.2024.105714

   

• Koskinen M.-K., Laine M., …, Hovatta I. Node of Ranvier remodeling in chronic psychosocial stress and anxiety. Neurophsycopharmacology. 2023; 48:1532-1540 https://doi.org/10.1038/s41386-023-01568-6

• Koskinen M.-K., Hovatta I. Genetic insights into the neurobiology of anxiety. Trends in Neuroscience. 2023; 46(4):318-331 doi.org/10.1016/j.tins.2023.01.007

• Gigliotta A., Trontti K., …, Hovatta I. Gene expression profiling reveals a role of immune system and inflammation in innate and stress-induced anxiety-like behavior. Frontiers in Genetics. 2023; 14:1173376. https://doi.org/10.3389/fgene.2023.1173376

• Als T. D., …, Naamanka J., …, Hovatta I., …, Børglum A. D. Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. Nature Med. 2023; 29, 1832–1844 https://doi.org/10.1038/s41591-023-02352-1
   
• Kurki M. I., … Hovatta I., …, Palotie A. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023; 613, 508-518. https://doi.org/10.1038/s41586-022-05473-8
   
• Kurki S. M., …, Hovatta I., …, Virtanen M. A. Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development. Cerebral Cortex. 2023; 33, 5906-5923 doi.org/10.1093/cercor/bhac470

2022

• Jäntti H., …, Trontti K., …, Hovatta I., …, Rolova T. Human PSEN1 mutant glia improe spatial learning and memory in aged mice. Cells. 2022; 11(24), 4116 doi.org/10.3390/cells11244116

• Koskuvi M, Lehtonen Š, ..., Hovatta I., ..., Koistinaho J. Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia. Glia. 2022;70(4):650-660. doi:10.1002/glia.24131

2021

• Cui H, Kilpeläinen T, ... , Hovatta I., ..., Myöhänen TT. Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy. J Cell Mol Med. 2021;25(20):9634-9646. doi:10.1111/jcmm.16910
   
• Mingardi J, La Via L, ... , Hovatta I., ..., Barbon A. miR-9-5p is involved in the rescue of stress-dependent dendritic shortening of hippocampal pyramidal neurons induced by acute antidepressant treatment with ketamine. Neurobiol Stress. 2021;15:100381. Published 2021 Aug 12. doi:10.1016/j.ynstr.2021.100381
   
• Ämmälä AJ, Suvisaari J, ..., Hovatta I.,  Childhood adversities are associated with shorter leukocyte telomere length at adult age in a population-based study. Psychoneuroendocrinology. 2021;130:105276. doi:10.1016/j.psyneuen.2021.105276
   
• Linnaranta O, Trontti KT, ... ,Hovatta I., ..., Suvisaari J. Peripheral metabolic state and immune system in first-episode psychosis - A gene expression study with a prospective one-year follow-up. J Psychiatr Res. 2021;137:383-392. doi:10.1016/j.jpsychires.2021.03.013
   
• Sindi S, Solomon A, Kåreholt I, ... & Hovatta I., Kivipelto M. Telomere Length Change in a Multidomain Lifestyle Intervention to Prevent Cognitive Decline: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2021;76(3):491-498. doi:10.1093/gerona/glaa279
• Sokolowska E, Viitanen R, Misiewicz Z, ... & Hovatta I., The circadian gene Cryptochrome 2 influences stress-induced brain activity and depressive-like behavior in mice. Genes Brain Behav. 2021;20(4):e12708. doi:10.1111/gbb.12708

2020

• Laurikainen H, Vuorela A, Toivonen A, ... & Hovatta I. Elevated serum chemokine CCL22 levels in first-episode psychosis: associations with symptoms, peripheral immune state and in vivo brain glial cell function. Transl Psychiatry. 2020;10(1):94. Published 2020 Mar 16. doi:10.1038/s41398-020-0776-z
• Ämmälä AJ, Vitikainen EIK, Hovatta I., ... & Suvisaari J. Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns. Sci Rep. 2020;10(1):13986. Published 2020 Aug 19. doi:10.1038/s41598-020-71000-2
   
• Mennesson M, Orav E, Gigliotta A, ... & Hovatta, I. Kainate Receptor Auxiliary Subunit NETO2-Related Cued Fear Conditioning Impairments Associate with Defects in Amygdala Development and Excitability. eNeuro. 2020;7(4):ENEURO.0541-19.2020 DOI:10.1523/ENEURO.0541-19.2020
   
• Oksanen M, Hyötyläinen I, Trontti K, ... & Hovatta, I. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes. Glia. 2020;68(3):589-599. DOI:10.1002/glia.23741
• Li C., Stoma S., Lotta LA., Warner S., Albrecht E., Allione A., ... Hovatta I., ..., & Codd V. Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. Am J Hum Genet. 2020;106(3):389-404. DOI:10.1016/j.ajhg.2020.02.006

2019

• Rouhiainen, A., Kulesskaya, N., Mennesson, M., Misiewicz, Z., Sipilä, T., Sokolowska, E., ... & Hovatta, I. (2019). The bradykinin system in stress and anxiety in humans and mice. Scientific Reports, 9, 19437. DOI: 10.1038/s41598-019-55947-5.
• Forstner, A.J., Awasthi, S., Wolf, C., Maron, E., Erhardt, A., Czamara, D., ... Hovatta, I., ... , & Schumacher, J. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. Mol Psychiatry. DOI:10.1038/s41380-019-0590-2. Epub ahead of print
• Oksanen, M., Hyötyläinen, I., Trontti, K., Rolova, T., Wojciechowski, S., Koskuvi, M., ... , Hovatta, I., ... , & Koistinaho, J. NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes. Glia. DOI:10.1002/glia.23741. Epub ahead of print
• Misiewicz, Z., Iurato, S., Kulesskaya, N., Salminen, L., Rodrigues, L., Maccarrone, G., ... & Hovatta, I. (2019). Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior. PLoS Genetics, 15(9), e1008358. DOI: 10.1371/journal.pgen.1008358
• Sinha, V., Ukkola-Vuoti, L., Ortega-Alonso, A., Torniainen-Holm, M., Therman, S., Tuulio-Henriksson, A., ... , Hovatta, I., ... , & Hennah, W. Variants in regulatory elements of  PDE4D associate with major mental illness in the Finnish population. Mol Psychiatry. DOI:10.1038/s41380-019-0429-x
• Meier, S.M., Trontti, K., Purves, K.L., Damm, T., Grove, J., Laine, M.A., ... Hovatta, I., Mattheisen, M., & Mors, Ole. (2019) Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study. JAMA Psychiatry, 76(9), 924-932. DOI:10.1001/jamapsychiatry.2019.1119
• Mantere, O., Trontti, K., García-González, J., Balcells, I., Saarnio, S., Mäntylä, T., ... , Hovatta, I., & Suvisaari, J. Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis. J Psychiatr Res, 109, 18-26. DOI:10.1016/j.jpsychires.2018.11.008
• Mennesson, M., Rydgren, E., Lipina, T., Sokolowska, E., Kulesskaya, N., Morello, F., ... & Hovatta, I. (2019). Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction. Neuropsychopharmacology, 44, 1855–1866. DOI: 10.1038/s41386-019-0344-5

2018

• Laine, M. A., Trontti, K., Misiewicz, Z., Sokolowska, E., Kulesskaya, N., Heikkinen, A., ... & Hovatta, I. (2018). Genetic Control of Myelin Plasticity After Chronic Psychosocial Stress. eNeuro, 5(4). DOI: 10.1523/ENEURO.0166-18.2018
• Trontti, K., Väänänen, J., Sipilä, T., Greco, D., & Hovatta, I. (2018). Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression. RNA, 24(5), 643-655. DOI: 10.1261/rna.064881.117
• Mantere, O., Trontti, K., García-González, J., Balcells, I., Saarnio, S., Mäntylä, T., ... Hovatta, I., Suvisaari, J.  (2018). Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis. Journal of Psychiatric Research, 109, 18-26. DOI:10.1016/j.jpsychires.2018.11.008
• Gielen, M., Hageman, G. J., Antoniou, E. E., Nordfjall, K., Mangino, M., Balasubramanyam, M., ... Hovatta, I., ... Zeegers, M.P., TELOMAAS group. (2018) Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. The American Journal of Clinical Nutrition, 108(3), 453–475. DOI: 10.1093/ajcn/nqy107

2017

• Laine, M. A., Sokolowska, E., Dudek, M., Callan, S.-A., Hyytiä, P., & Hovatta, I. (2017). Brain activation induced by chronic psychosocial stress in mice. Scientific Reports, 7, [15061]. DOI: 10.1038/s41598-017-15422-5
• Sindi, S., Ngandu, T., Hovatta, I., Kåreholt, I., Antikainen, R., Hänninen, T., Levälahti, E., ...  FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. Journal of Alzheimer's Disease, 59(4), 1459-1470. DOI: 10.3233/JAD-170123
• Vincent, J., Hovatta, I., Frissa, S., Goodwin, L., Hotopf, M., Hatch, S. L., ... & Powell, T. R. Assessing the contributions of childhood maltreatment subtypes and depression case-control status on telomere length reveals a specific role of physical neglect. Journal of Affective Disorders, 213, 16-22. DOI: 10.1016/j.jad.2017.01.031

2016

• Misiewicz, Z., Hiekkalinna, T. S., Paunio, T. M., Varilo, T. T., Terwilliger, J., Partonen, T., & Hovatta, I. M. (2016). A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate. Scientific Reports, 6, [39345]. DOI: 10.1038/srep39345
• Berglund, K., Reynolds, C. A., Ploner, A., Gerritsen, L., Hovatta, I., Pedersen, N. L., & Hägg, S. (2016). Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk. Aging Clinical and Experimental Research, 8(7), 1398-1415. DOI: 10.18632/aging.100995

2015

• Walsh, K. M., Codd, V., Rice, T., Nelson, C. P., Smirnov, I. V., McCoy, L. S., ... Hovatta, I. (2015). Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget, 6(40), 42468-42477. DOI: 10.18632/oncotarget.6468
• Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., ... Hietakangas, V. (2015). Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Reports, 13(2), 350-364. DOI: 10.1016/j.celrep.2015.08.081
• Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., ... NABEC UKBEC Consortium (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, [8570]. DOI:10.1038/ncomms9570
• Hovatta, I. (2015). Genetic influence on CNS gene expression: impact on behavior. ( Reference Module in Biomedical Sciences; Vol. 2015). Elsevier Academic Press. DOI: 10.1016/B978-0-12-801238-3.04601-8
• Hovatta, I. (2015). Genetics: Dynamic Cellular Aging Markers Associated with Major Depression. Current Biology, 25(10), R409-R411. DOI: 10.1016/j.cub.2015.03.036

2014

• Broer, L., Raschenberger, J., Deelen, J., Mangino, M., Codd, V., Pietilainen, K. H., ... Ladwig, K-H. (2014). Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. European Journal of Epidemiology, 29(9), 629-638. DOI: 10.1007/s10654-014-9940-1
• Walsh, K. M., Codd, V., Smirnov, I. V., Rice, T., Decker, P. A., Hansen, H. M., ... Hovatta, I. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46(7), 731-735. DOI: 10.1038/ng.3004
• Rossi, M., Kilpinen, L. H., Muona, M., Surakka, I., Ingle, C., Lahtinen, J., ... Hovatta, I. (2014). Allele-specific regulation of DISC1 expression by miR-135b-5p. European Journal of Human Genetics, 22(6), 840-843. DOI: 10.1038/ejhg.2013.246
• Albrecht, E., Sillanpaa, E., Karrasch, S., Alves, A. C., Codd, V., Hovatta, I., ... Schulz, H. (2014). Telomere length in circulating leukocytes is associated with lung function and disease.European Respiratory Journal, 43(4), 983-992. DOI: 10.1183/09031936.00046213
• Joensuu, T., Tegelberg, S., Reinmaa, E., Segerstrale, M., Hakala, P., Pehkonen, H., ... Lehesjoki, A-E. (2014). Gene Expression Alterations in the Cerebellum and Granule Neurons of Cstb(-/-) Mouse Are Associated with Early Synaptic Changes and Inflammation. PLoS One, 9(2), [89321]. DOI: 10.1371/journal.pone.0089321

2013

• Nieratschker, V., Lahtinen, J., Meier, S., Strohmaier, J., Frank, J., Heinrich, A., ... Hovatta, I. (2013). Longer telomere length in patients with schizophrenia. Schizophrenia Research,149(1-3), 116-120. DOI: 10.1016/j.schres.2013.06.043
• Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., ... CARDIoGRAM Consortium (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45(4), 422-427. DOI: 10.1038/ng.2528
• Kouri, V-P., Olkkonen, J., Kaivosoja, E., Ainola, M-M., Juhila, J., Hovatta, I., ... Mandelin, J. (2013). Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level.PLoS One, 8(1), Article Number: e54049. DOI: 10.1371/journal.pone.0054049
• Sokolowska, E., & Hovatta, I. (2013). Anxiety genetics-findings from cross-species genome-wide approaches. Biology of mood & anxiety disorders , 3(9). DOI: 10.1186/2045-5380-3-9

2012

• Tiainen, A-M. K., Mannisto, S., Blomstedt, P. A., Moltchanova, E., Perala, M-M., Kaartinen, N. E., ... Eriksson, J. G. (2012). Leukocyte telomere length and its relation to food and nutrient intake in an elderly population. European Journal of Clinical Nutrition, 66(12), 1290-1294. DOI: 10.1038/ejcn.2012.143
• Kajantie, E., Pietilainen, K. H., Wehkalampi, K., Kananen, L., Räikkönen, K., Rissanen, A., ... Hovatta, I. (2012). No association between body size at birth and leucocyte telomere length in adult life-evidence from three cohort studies. International Journal of Epidemiology, 41(5), 1400-1408. DOI: 10.1093/ije/dys127 
• Savolainen, K., Räikkönen, K., Kananen, L., Kajantie, E., Hovatta, I., Lahti, M., ... Eriksson, J. G. (2012). History of mental disorders and leukocyte telomere length in late adulthood: The Helsinki Birth Cohort Study (HBCS). Journal of Psychiatric Research, 46(10), 1346-1353. DOI: 10.1016/j.jpsychires.2012.07.005
• Hovatta, I., de Mello, V. D. F., Kananen, L., Lindstrom, J., Eriksson, J. G., Ilanne-Parikka, P., ... Uusitupa, M. (2012). Leukocyte Telomere Length in the Finnish Diabetes Prevention Study. PLoS One, 7(4), Article Number: e34948. DOI: 10.1371/journal.pone.0034948
• Polvi, A., Linnankivi, T., Kivela, T., Herva, R., Keating, J. P., Makitie, O., ... Lehesjoki, A-E. (2012). Mutations in CTC1, Encoding the CTS Telomere Maintenance Complex Component 1, Cause Cerebroretinal Microangiopathy with Calcifications and Cysts. American Journal of Human Genetics, 90(3), 540-549. DOI: 10.1016/j.ajhg.2012.02.002
• Donner, J., Sipila, T., Ripatti, S., Kananen, L., Chen, X., Kendler, K. S., ... Hovatta, I. (2012). Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. American journal of medical genetics. Part B, Neuropsychiatric genetics, 159B(3), 316-327. DOI: 10.1002/ajmg.b.32029
• Ahola, K., Siren, I., Kivimaki, M., Ripatti, S., Aromaa, A., Lönnqvist, J., & Hovatta, I. (2012). Work-Related Exhaustion and Telomere Length: A Population-Based Study. PLoS One,7(7), Article Number: e40186. DOI: 10.1371/journal.pone.0040186

2011

• Hovatta, I. (2011). Ahdistuneisuuden biologiaa. Suomen lääkärilehti, 66( 36), 2585-90.
• Vollert, C., Zagaar, M., Hovatta, I., Taneja, M., Vu, A., Dao, A., ... Salim, S. (2011). Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms. Behavioural Brain Research, 224(2), 233-240. DOI: 10.1016/j.bbr.2011.05.010
• Muinos-Gimeno, M., Espinosa-Parrilla, Y., Guidi, M., Kagerbauer, B., Sipilae, T., Maron, E., ... Estivill, X. (2011). Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. Biological Psychiatry, 69(6), 526-533. DOI: 10.1016/j.biopsych.2010.10.010
• Juhila, J., Sipila, T., Icay, K., Nicorici, D., Ellonen, P., Kallio, A., ... Hovatta, I. (2011). MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus. PLoS One, 6(6), e21495. DOI: 10.1371/journal.pone.0021495
• Salim, S., Asghar, M., Taneja, M., Hovatta, I., Wu, Y-L., Saha, K., ... Hite, B. (2011). Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Letters,585(9), 1375-1381. DOI: 10.1016/j.febslet.2011.04.023
• Salim, S., Asghar, M., Taneja, M., Hovatta, I., Chugh, G., Vollert, C., & Vu, A. (2011). Potential contribution of oxidative stress and inflammation to anxiety and hypertension.Behavioural Brain Research, 1404, 63-71. DOI: 10.1016/j.brainres.2011.06.024
• Hovatta, I. (2011). Telomeerien pituus mielenterveyden häiriöissä. Duodecim, 127(15), 1516-1517.
• Kas, M. J., Kahn, R. S., Collier, D. A., Waddington, J. L., Ekelund, J., Porteous, D. J., ... Hovatta, I. (2011). Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man. Science translational medicine, 3(102). DOI: 10.1126/scitranslmed.3002917

2010

• Sipila, T., Kananen, L., Greco, D., Donner, J., Silander, K., Terwilliger, J. D., ... Hovatta, I. (2010). An Association Analysis of Circadian Genes in Anxiety Disorders. Biological Psychiatry, 67(12), 1163-1170. DOI: doi:10.1016/j.biopsych.2009.12.011
• Donner, J., Haapakoski, R., Ezer, S., Melen, E., Pirkola, S., Gratacos, M., ... Hovatta, I. (2010). Assessment of the Neuropeptide S System in Anxiety Disorders. Biological Psychiatry,68(5), 474-483. DOI: 10.1016/j.biopsych.2010.05.039
• Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lönnqvist, J., Peltonen, L., ... Hovatta, I. (2010). Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls. PLoS One, 5. DOI: 10.1371/journal.pone.0010826
• Tyynismaa, H., Carroll, C. J., Raimundo, N., Ahola-Erkkilä, S. T., Wenz, T., Ruhanen, H., ... Suomalainen, A. (2010). Mitochondrial myopathy induces a starvation-like response.Human Molecular Genetics, 19(20), 3948-3958. DOI: 10.1093/hmg/ddq310
• Hovatta, I., & Sipilä, T. L. M. (2010). Molecular genetics of anxiety. In Encyclopedia of Life Sciences John Wiley & Sons Ltd.
• Eerola, J., Kananen, L., Manninen, K., Hellstrom, O., Tienari, P. J., & Hovatta, I. (2010). No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(11), 1181-1184. DOI: 10.1093/gerona/glq125
• Hovatta, I., Juhila, J., & Donner, J. (2010). Oxidative stress in anxiety and comorbid disorders. Neuroscience Research, 68(4), 261-275. DOI: 10.1016/j.neures.2010.08.007
• Winn, M. E., Zapala, M. A., Hovatta, I., Risbrough, V. B., Lillie, E., & Schork, N. J. (2010). The effects of globin on microarray-based gene expression analysis of mouse blood.Mammalian Genome, 21(5-6), 268-275. DOI: 10.1007/s00335-010-9261-y
• Hovatta, I., Tienari, P., Sajantila, A., & Wartiovaara, A. (2010). Tutkijoiden kouluttajien haasteet. Duodecim, 126(19), 2301-2303.

2009

• Hovatta, I. (2009). A functional genomics approach reveals a role for oxidative stress in the regulation of anxiety Neuroscience Research 65 ELSEVIER IRELAND LTD. DOI:10.1016/j.neures.2009.09.1672
• Raimundo, N., Vanharanta, S., Aaltonen, L. A., Hovatta, I., & Suomalainen, A. (2009). Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas. Oncogene, 28(9), 1261-1273. DOI: 10.1038/onc.2008.472
• Hovatta, I. (2009). Genetic influence on CNS gene expression: impact on behavior. In E. L. R. S. (Ed.), Encyclopedia of neuroscience (pp. 647-654). Amsterdam: Elsevier Academic Press.
• Zapala, M. A., Barlow, C., & Hovatta, I. (2009). Molecular anatomy of the mammalian brain. In Encyclopedia of Neuroscience: volume 4 (pp. 913-919). Oxford: Academic Press.

2008

• Donner, J., Pirkola, S., Silander, K., Kananen, L., Terwilliger, J., Lönnqvist, J., ... Hovatta, I. (2008). An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Biological Psychiatry, 64(8), 672-680. DOI: 10.1016/j.biopsych.2008.06.002
• von Schantz, C., Saharinen, J., Kopra, O., Cooper, J. D., Gentile, M., Hovatta, I., ... Jalanko, A. (2008). Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases. BMC Genomics, 9(146), 1-14. DOI: 10.1186/1471-2164-9-146
• Hovatta, I., & Paunio, T. (2008). Mieli, keho ja geenit. Duodecim, 124(6), 675-677.
• Hovatta, I., & Barlow, C. (2008). Molecular genetics of anxiety in mice and men. Annals of Medicine, 40(2), 92-109. DOI: 10.1080/07853890701747096
• Rehnströ, K., Ylisaukko-oja, T., Vanhala, R., Vendt, L. V., Peltonen, L., Hovatta, I., ... Wendt, L. V. (2008). No association between common variants in glyoxalase 1 and autism spectrum disorders. American journal of medical genetics. Part B, Neuropsychiatric genetics, 147B(1), 124-127. DOI: 10.1002/ajmg.b.30582
• Hovatta, I., & Mäkelä, T. (2008). Uusia malleja menestyvän tutkijan vakinaistamiselle. Duodecim, 124, 2555-9.

2007

• Hovatta, I. (2007). Ahdistuneisuuden genetiikka: spesifisten geenien tunnistus on alkanut : [pääkirjoitus]. Duodecim, 123(14), 1665-1666.
• Hovatta, I., Zapala, M. A., Broide, R. S., Schadt, E. E., Schork, N. J., Lockhart, D. J., & Barlow, C. (2007). DNA variation and brain-region specific expression profiles show different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biology, 8(R25). DOI: 10.1186/gb-2007-8-2-r25

2006

• Luiro, K. M., Kopra, O., Blom, J. T., Gentile, M., Mitchison, H., Hovatta, I., ... Jalanko, A. (2006). Batten disease (JNCL) is linked to disturbances in mitochondrial, cytoskeletal, and synaptic compartments. Journal of Neuroscience Research, 84(5), 1124-1138. DOI: 10.1002/jnr.21015
• von Schantz, C., Heine, C., Kopra, O., Hovatta, I., Peltonen, L., Kyttala, A., & Jalanko, A. (2006). Common Molecular Pathways Underlying Neuronal Ceroid Lipofuscinosis? Molecular Biology of the Cell, 17.
• Hovatta, I. (2006). Hiirtä ahdistavat entsyymit. Duodecim, 123, 1665-1666.

2005

• Zapala, M. A., Hovatta, I., Ellison, J. A., Wodicka, L., Del Rio, J. A., Tennant, R., ... Barlow, C. (2005). Adult mouse brain gene expression patterns bear an embryologic imprint. Proceedings of the National Academy of Sciences of the United States of America, 102, 10357-10362. DOI: 10.1073/pnas.0503357102
• Hovatta, I., & Saarela, J. (2005). Affymetrix GeneChip system. In J. Tuimala, & M. M. Laine (Eds.), DNA Microarray Data Analysis (pp. 25-31). CSC - Scientific Computing.
• Hovatta, I., & Barlow, C. (2005). Genome to Disease. In S. H. Koslow, & S. Subramaniam (Eds.), Databasing the Brain: Data to Knowledge (pp. 169-190). John Wiley & Sons Ltd.
• Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., ... Barlow, C. (2005). Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature, 438, 662-666. DOI:10.1038/nature04250

2004

• Arajarvi, R., Haukka, J., Varilo, T., Suokas, J. T., Juvonen, H., Suvisaari, J., ... Lönnqvist, J. (2004). Clinical phenotype of schizophrenia in a Finnish isolate. Schizophrenia Research,67, 195-205. DOI: 10.1016/S0920-9964(03)00007-0

2001

• Ekelund, J., Hovatta, I., Parker, A., Paunio, T., Varilo, T., Martin, R., ... Palotie, L. (2001). Chromosome 1 loci in Finnish schizophrenia families. Human Molecular Genetics, 10, 1611-1617.
• Paunio, T., Ekelund, J., Varilo, T., Parker, A., Hovatta, I., Turunen, J. A., ... Palotie, L. (2001). Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Human Molecular Genetics, 10, 3037-3048.
• Lahdelma, L., Ahokas, A., Andersson, L. C., Suvisaari, J., Hovatta, I., Huttunen, M. O., & Koskimies, S. (2001). Mitchell B. Balter Award. Human leukocyte antigen-A1 predicts a good therapeutic response to clozapine with a low risk of agranulocytosis in patients with schizophrenia. Journal of Clinical Psychopharmacology, 21, 4-7. DOI: 10.1097/00004714-200102000-00002

2000

• Virolainen, E., Wessman, M., Hovatta, I., Niemi, K. M., Ignatius, J., Kere, J., ... Palotie, A. (2000). Assignment of a novel locus for autosomal recessive congenital ichthyosis chromosome 19p13.1-p13.2. American Journal of Human Genetics, 2000(66), 1132-1137. DOI: 10.1086/302813
• Kaunisto, M., Hamalainen, E., Kallela, M., Harno, H., Marttila, P., Hovatta, I., ... Wessman, M. (2000). Exclusion of CACNA1A and KCNN1 as candidate genes for migraine in three 19p13-linked Finnish families. American Journal of Human Genetics 67 Cell Press.
• Varilo, T., Laan, M., Hovatta, I., Wiebe, V., Terwilliger, J. D., & Palotie, L. (2000). Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo.European Journal of Human Genetics, 8, 604-612. DOI: 10.1038/sj.ejhg.5200482

1999

• Hovatta, I., Varilo, T., Suvisaari, J., Terwilliger, J. D., Ollikainen, V., Arajarvi, R., ... Palotie, L. (1999). A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. American Journal of Human Genetics, 65, 1114-1124. DOI: 10.1086/302567
• Kaunisto, M., Kallela, M., Marttila, P., Farkkila, M., Havanka, H., Hamalainen, E., ... Wessman, M. (1999). Genetic studies on Finnish families with familial hemiplegic migraine.American Journal of Human Genetics 65 Cell Press.

1998

• Pekkarinen, P., Hovatta, I., Hakola, P., Jarvi, O., Kestila, M., Lenkkeri, U., ... Peltonen, L. (1998). Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13. American Journal of Human Genetics, 62, 362-372.

1994

• Hovatta, I., Kallela, K. M. J., Färkkilä, M., & Peltonen, L. (1994). Familial migraine: exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p.Genomics, 1994(23), 707-709. DOI: 10.1006/geno.1994.1563
• Hovatta, I., Seppälä, J., Pekkarinen, P., Tanskanen, A. J., Lönnqvist, J., & Palotie, L. (1994). Linkage analysis in two schizophrenic families originating from a restricted subpopulation of Finland. Psychiatric Genetics, 4(3), 143-152.

2024

• Adrien Gigliotta: Stress-induced anxiety and myelin plasticity : insights from in vivo and in vitro studies University of Helsinki, Finland

2021

• Mikaela Laine: Myelin plasticity in mouse resilience and susceptibility to psychosocial stress – implications for anxiety disorders, University of Helsinki, Finland

2019

• Marie Mennesson: Kainate receptor auxiliary subunits NETO1 and NETO2 in anxiety and fear-related behaviors, University of Helsinki, Finland. 
• Zuzanna Misiewicz: What Makes Us Anxious: A Cross-Species Multi-omics Approach to the Biological Basis of Anxiety Disorders, University of Helsinki, Finland. Approved with distinction.

2012                      

• Jonas Donner: Candidate gene studies in human anxiety disorders, University of Helsinki, Finland. Approved with distinction. 

2010                      

• Helena Kilpinen (together with Leena Peltonen-Palotie): Genetic mechanisms underlying autism spectrum disorders, University of Helsinki, Finland. Approved with distinction. 

2024

• Karyna Sydorska: Deep learning: novel approach to examine the effects of sleep fragmentation on anxiety-like behaviour in female mice, University of Helsinki, Finland
• Nelli Frilander: Increased risk of general medical conditions in anxiety disorder cases An evaluation of comorbidity, University of Helsinki, Finland

2023

• Emma Pirola: Study of mechanisms of resilience and vulnerability to chronic midl stress in rats: a role for inflammation? University of Helsinki, Finland and University of Milan-Bicocca, Italy
• Eleonora Manenti: University of Helsinki, Finland and University of Milan, Italy
• Malvina Millet: University of Helsinki, Finland
• Rawan Othman: Generation and validation of an adeno-associated vector for the silencing of a myelin-related gene, University of Helsinki, Finland and University of Milan, Italy
• Maiju Savolaninen: TrkB signaling and fluoxetine in paravalbumin interneuron myelination, University of Helsinki, Finland

2022

• Filippo Buso: The role of microRNAs in myelin plasticity in relation with stress-induced anxiety, University of Helsinki, Finland and University of Milan, Italy
• Maiju Lindberg: Chronic sleep fragmentation induces anxiety-like behaviour in female mice, University of Helsinki, Finland 

2021

• Emmi Olkkonen: Oligodendrocyte long non-coding RNAs in mouse chronic psychosocial stress, University of Helsinki, Finland
• Giulia Mazzini: A putative role for vHPC-mPFC projection in the regulation of anxiety-like behavior in mice, University of Helsinki, Finland and University of Milan, Italy
• Federica Cafaro: A crosstalk between oligodendrocyte progenitor cells and microglia in the susceptibility to chronic psychosocial stress, University of Helsinki, Finland and University of Milan, Italy
• Laura Sokka: The effect of stress on Zebrafish lactase expression, Univeristy of Helsinki, Finland

2019

• Sarah Journée: Myelin density and nodes of Ranvier in chronic psychosocial stress, University of Helsinki, Finland

2018

• Emilie Rydgren: The effect of NETO2 on synaptosomal kainate receptor subunit levels in fear-related brain regions, University of Helsinki, Finland
• Joni Tiilikainen: Micro-RNAs in chronic stress, University of Helsinki, Finland
• Aino Heikkinen: Number of oligodendrocytes and size of the myelinated area in mice exposed to chronic psychosocial stress, University of Helsinki, Finland

2017

• Laura Salminen: The effect of homocysteine on telomere length, University of Helsinki, Finland

2016                      

• Lea Urpa: Mouse strain-specific differences in transposable element expression following psychosocial stress, University of Helsinki, Finland
• Mikaela Laine: Resilience to psychosocial stress associates with altered myelination in the mouse cortex, University of Helsinki, Finland

2014                      

• Judit Garcia Gonzalez: Blood cell gene expression analysis of CDCL1 and TGFA in first episode psychosis patients, Polytechnic University of Valencia, Spain

2011                      

• Katherine Icay: Identifying putative microRNA-regulated biological networks with bioinformatics tools, University of Helsinki, Finland                      
• Kaisa Manninen: The role of Gsr in the regulation of anxiety-like behavior, University of Helsinki, Finland

2009                      

• Pia Rasinkangas: Haem biosynthesis in anxiety: gene expression analysis and lentivirus vector construction for functional studies, University of Oulu, Finland

2008                       

• Tessa Sipilä: Circadian clock-related genes as candidate genes for anxiety disorders, University of Jyväskylä, Finland

2007                      

• Jonas Donner: A genetic analysis of thirteen anxiety candidate genes, University of Helsinki, Finland