We employ techniques based on both mass spectrometry (PTR-MS, GS-MS) and optical spectroscopy (cavity enhanced and photoacoustic). Recently, we have developed a novel hyphenated technique that combines sensitive optical spectroscopy with chromatographic separation.
In addition to various spectroscopic instruments and setups, our lab includes a state-of-the-art proton transfer reaction time-of-flight mass spectrometer (Ionicon PTR-TOF-MS 1000).
Some of our publications from recent years include:
- K. Roslund, M. Lehto, P. Pussinen and M. Metsälä ”Volatile Composition of the Morning Breath”, J. Breath Res 16 (2022) 046010 link
- K. Roslund, M. Lehto, K. Hartonen, P. Pussinen, P-H. Groop, L. Halonen and M. Metsälä ”Identifying volatile in vitro biomarkers for oral bacteria with proton-transfer-reaction mass spectrometry and gas chromatography-mass spectrometry.”, Sci. Rep. 11 (2021) 16897 link
- T. Tomberg, N. Vuorio, T. Hieta, M. Jussila, K. Hartonen, M. Vainio, T. Mikkonen, J. Toivonen, M.-L. Riekkola, L. Halonen and M. Metsälä, "Broadband Laser-Based Infrared Detector for Gas Chromatography". Anal. Chem. 92, 14582-14588 (2020). link
- K. Roslund, M. Lehto, P. Pussinen, P.-H. Groop, L. Halonen and M. Metsälä, "On-line profiling of volatile compounds produced in vitro by pathogenic oral bacteria". J. Breath Res. 14, 016010 (2020). link
- B. Henderson, A. Khodabakhsh, M. Metsälä, I. Ventrillard, F. M Schmidt, D. Romanini, G.A.D. Ritchie, S. te Lintel Hekkert, R. Briot, T. Risby, N. Marczin, F.J.M. Harren and S.M. Cristescu, "Laser spectroscopy for breath analysis: towards clinical implementation". Applied Physics B 124, 1-21 (2018). link
A complete list of Dr. Metsälä's publications can be found here.