Medical Nutrition Physiology group investigates intestinal health from various perspectives. The individual projects under these themes are listed below.
Commensal bacteria in the attenuation of inflammation

The intestine is home to a vast ecosystem of microbes which have proven to be important regulators of host physiology and metabolism. We aim to identify commensal bacterial strains and novel bacterial effector molecules with potential to attenuate intestinal inflammation. 

Main researcher: Dr Veera Kainulainen

Intestinal renin-angiotensin-aldosterone system (RAAS)

Renin-angiotensin system is a well-known main regulator of blood pressure, but recent studies have also characterized local production of RAS components in various organs including the intestine.

Several PhD theses have studied the role of bioactive peptides in elevated blood pressure and vascular reactivity. One of our novel findings is the local intestinal tissue steroidogenesis, such as corticosterone and aldosterone production.

Our present research aim is to expand the current knowledge of intestinal RAAS (RAS+aldosterone) and investigate its regulation and role in intestinal inflammation.

Main researchers: Hanna Launonen, Zan Pang, Lauri Varmavuori

Dietary fat, ketosis, and intestinal inflammation

Both quality and quantity of dietary fat can influence intestinal health. Our novel finding showed that the profile of bile acids affects the intestinal permeability.  Our present research focuses on how dietary fat quality, nutritional ketosis, and exogenous ketone bodies can impact intestinal inflammation.

Main researcher: Lotta Luiskari