People

Adjunct professor

I am interested in how our immune cells get to the places where they are needed in the body and how they talk to each other. I am trying to understand the molecular background of immune cell adhesion and communication through integrin-mediated processes and extracellular vesicles. My previous research work has investigated cytoskeleton-mediated regulation of cells in brain tumors and muscle diseases.

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Adjunct professor

Many tumor types including leukemia and breast cancer are able to grow in the bone marrow and induce deep hypoxia. We study, how tumor cells absorb oxygen from surrounding normal tissue and in this way resemble embryonal cells. We have established a three-dimensional culture model of the bone marrow to develop specific inhibitors for tumor cell growth in hypoxia.

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Ph.D. Postdoctoral fellow

My academic background is in disease-related neuroinflammation research and I am primarily involved in the project studying the role of neuronal ICAM5 in neuron-microglia communication. I am also interested in integrin crosstalk in microglia and monocytes, and its role in cellular adhesion and migration. I am currently supervising one PhD student.

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Publications:

A. PEER-REVIEWED SCIENTIFIC ARTICLES
1.Rolova, T., H. Dhungana, P. Korhonen, P. Valonen, N. Kolosowska, H. Konttinen, K. Kanninen, H. Tanila, T. Malm, and J. Koistinaho. Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage. Aging Dis (2016) 7:450-465.

2.Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. Neurobiol Dis. (2014) 64:16-29.

3.Dhungana H, Rolova T, Savchenko E, Wojciechowski S, Savolainen K, Ruotsalainen AK, Sullivan PM, Koistinaho J, Malm T. Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele. J Neuroinflammation (2013) 10(1):102

4.Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Kanninen K, Malm T, Koistinaho J. Does Nrf2 gene transfer facilitate recovery after contusion spinal cord injury? Antioxid Redox Signal. (2013) in press.

5.Magga J, Savchenko E, Malm T, Rolova T, Lehtonen S, Jantunen E, Aarnio J, Lehenkari P, Koistinaho M, Muona A, Koistinaho J. Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer's disease. J Cell Mol Med. (2012) 16(5):1060-73.

6.Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. (2009) 106(38):16505-10.

7.Ivask A, Rõlova T, Kahru A. A suite of recombinant luminescent bacterial strains for the quantification of bioavailable heavy metals and toxicity testing. BMC Biotechnol. (2009) 9(41).
Bondarenko O, Rõlova T, Kahru A, Ivask A. Bioavailability of Cd, Zn and Hg in Soil to Nine Recombinant Luminescent Metal Sensor Bacteria. Sensors (2008) 8(11): 6899-6923.

B. NON-REFEREED SCIENTIFIC PUBLICATIONS (POSTERS)
1.Rõlova T, Yoshiike, Y, Murayama, M., Koistinaho, J., Takashima, A. Minocycline inhibits formation of insoluble tau aggregates in vitro. Society for Neuroscience Annual Meeting 2010, November 2010, San Diego, CA, USA

2.Rõlova T, Malm TM, Vatanen T, Koistinaho J. Nuclear factor kappa B contributes to the engraftment of circulating leukocytes in response to intrahippocampal lipopolysaccharide injection. Society for Neuroscience Annual Meeting 2008, November 2008, Washington, DC, USA

G. THESES
Doctoral dissertation: “The regulation of neuroinflammation by nuclear factor kappa B and apolipoprotein E”. Kuopio, 2015
Master’s thesis: „Human hematopoietic stem and progenitor cells in neurodegenerative diseases: Development of a novel chimeric mouse model combining human hematopoietic system with the mouse background“. Kuopio, 2008
Bachelor’s thesis: „Construction and evaluation of Pseudomonas fluorescens OS8-based luminescent heavy metal sensor bacteria”. Tallinn, 2005.

 

Graduate student,  M.Sc.

ICAM-5 is a fascinating adhesion molecule of the brain and in concert with the beautiful microglia it has been my focus for the past years. The work on the interaction between neurons and microglia through ICAM-5 has brought novel insights into how the resident immune cells of the brain are regulated. 

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Graduate student, M.Sc.

My research goal is to reveal the signaling mechanisms of integrins specifically LFA-1, regulate leukocyte adhesion and migration.

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Graduate student, M.Sc.

Publications

Contact information:

esa.t.mikkola(at)helsinki.fi

Mail address:
University of Helsinki
Department of Biosciences and Biotechnology
Division of Biochemistry
P.O.Box 56
00014 University of Helsinki, Finland

Visiting address:
University of Helsinki
Department of Biosciences
Division of Biochemistry
Viikinkaari 9 C
00790 Helsinki, Finland

Graduate student, M.Sc.

It is essential to reveal the mechanism of integrin regulation since impaired integrin-mediated adhesion of leukocytes leads to fundamental defects of the immune system. Focus of my studies is the crosstalk between different members of the β2 family of integrins, which are expressed exclusively on leukocytes.

Publications:

Sokolov, D.I., Furaeva, K.N., Stepanova, O.I., Ovchinnikova, O.M., Viazmina, L.P., Kozonov, G.R., Kuzminykh, T.U. and Selkov, S.A., Changes  in  Functional Activity of JEG-3 Trophoblast Cell Line in the Presence  of  Factors  Secreted  by  Placenta. Arch Med Res. 2015. 46(4): 245-256.

Lvova, T.Yu., Stepanova, O.I., Viazmina, L.P., Okorokova, L.S., Belyakova, K.L., Belikova, M.E., Selkov, S.A., Sokolov, D.I., Effect of Factors Secreted by the Placenta on Phenotype of THP-1 Cells Cultured on a 3D Scaffold. Cell Technologies in Biology and Medicine. 2016. 1: 162-167

Contact information:

larisa.viazmina(at)helsinki.fi

Mail address:
University of Helsinki
Department of Biosciences and Biotechnology
Division of Biochemistry
P.O.Box 56
00014 University of Helsinki, Finland

Visiting address:
University of Helsinki
Department of Biosciences
Division of Biochemistry
Viikinkaari 9 C
00790 Helsinki, Finland

B.Sc.

Publications

Contact information:

sudarrshan.madhavan(at)helsinki.fi

Mail address:
University of Helsinki
Department of Biosciences and Biotechnology
Division of Biochemistry
P.O.Box 56
00014 University of Helsinki, Finland

Visiting address:
University of Helsinki
Department of Biosciences
Division of Biochemistry
Viikinkaari 9 C
00790 Helsinki, Finland