Ligand-gated liposomes incorporate specific molecular gates, such as aptamers, in their lipid bilayer that remain closed until they encounter a specific target biomolecule or a pathogenic cell (the ligand). Upon the lock-key binding of the ligand to aptameric gate of liposome, the liposome undergoes a conformational change that triggers the controlled release of its cargo. This mechanism allows for a highly specific, interactive response that is only activated in the presence of particular bio-target, making ligand-gated liposomes dynamic nanobiomaterials.
Combating resilient biofilms is a cornerstone application of our group's research. A antimicrobial resistant (AMR) dual species biofilm of Staphylococcus aureus and Pseudomonas aeruginosa is one of the biofilms we use as model to address this issue. We use different approaches to tackle biofilms; from combined treatments to combined antibiotic delivery and stimuli-responsive nanobiomaterial.