Selected publications

Selected publications of the group.

Kouri VP, Olkkonen J, Nurmi K, Peled N, Ainola M, Mandelin J, Nordström DC, Eklund KK. IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via IκBζ-dependent induction of ELF3. Rheumatology (Oxford). 2022 Jul
Bonato A, Zenobi-Wong M, Barreto G, Huang Z. A systematic review of microbiome composition in osteoarthritis subjects. Osteoarthritis Cartilage. 2022 Jun
Palomäki A; FinnGen Rheumatology Clinical Expert Group, Palotie A, Koskela J, Eklund KK, Pirinen M; FinnGen, Ripatti S, Laitinen T, Mars N. Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers. Ann Rheum Dis. 2021 Dec
Hetemäki I, Kaustio M, Kinnunen M, Heikkilä N, Keskitalo S, Nowlan K, Miettinen S, Sarkkinen J, Glumoff V, Andersson N, Kettunen K, Vanhanen R, Nurmi K, Eklund KK, Dunkel J, Mäyränpää MI, Schlums H, Arstila TP, Kisand K, Bryceson YT, Peterson P, Otava U, Syrjänen J, Saarela J, Varjosalo M, Kekäläinen E. Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Sci Immunol. 2021 Nov 26
Nurmi K, Niemi K, Kareinen I, Silventoinen K, Lorey MB, Chen Y, Kouri VP, Parantainen J, Juutilainen T, Öörni K, Kovanen PT, Nordström D, Matikainen S, Eklund KK. Native and oxidised lipoproteins negatively regulate the serum amyloid A-induced NLRP3 inflammasome activation in human macrophages. Clin Transl Immunology. 2021 Aug 3
Ulander L, Tolppanen H, Hartman O, Rissanen TT, Paakkanen R, Kuusisto J, Anttonen O, Nieminen T, Yrjölä J, Ryysy R, Drews T, Utriainen S, Karjalainen P, Anttila I, Nurmi K, Silventoinen K, Koskinen M, Kovanen PT, Lehtonen J, Eklund KK, Sinisalo J. Hydroxychloroquine reduces interleukin-6 levels after myocardial infarction: The randomized, double-blind, placebo-controlled OXI pilot trial. Int J Cardiol. 2021 Aug 15
Hiippala K, Barreto G, Burrello C, Diaz-Basabe A, Suutarinen M, Kainulainen V, Bowers JR, Lemmer D, Engelthaler DM, Eklund KK, Facciotti F, Satokari R. Novel Odoribacter splanchnicus Strain and Its Outer Membrane Vesicles Exert Immunoregulatory Effects in vitro. Front Microbiol. 2020 Nov 12
Jämsen E, Pajarinen J, Kouri VP, Rahikkala A, Goodman SB, Manninen M, Nordström DC, Eklund KK, Nurmi K. Tumor necrosis factor primes and metal particles activate the NLRP3 inflammasome in human primary macrophages. Acta Biomater. 2020 May;108
Nieminen HJ, Lampsijärvi E, Barreto G, Finnilä MAJ, Salmi A, Airaksinen AJ, Eklund KK, Saarakkala S, Pritzker KPH, Hæggström E. Localized delivery of compounds into articular cartilage by using high-intensity focused ultrasound. Sci Rep. 2019 Nov 4
Göös H, Fogarty C, Sahu B, Plagnol V, Rajamäki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, Järvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordström D, Flaumenhaft R, Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Lehto M, Notarangelo LD, Nejentsev S15, Eklund KK, Varjosalo M, Taipale J, Seppänen MRJ. Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy. J Allergy Clin Immunol. 2019 Jun 13.
Kaasinen E, Kuismin O, Rajamäki K, Ristolainen H, Aavikko M, Kondelin J, Saarinen S, Berta DG, Katainen R, Hirvonen EAM, Karhu A Taira A, Tanskanen T, Alkodsi A, Taipale M, Morgunova E, Franssila K, Lehtonen R, Mäkinen M, Aittomäki K, Palotie A, Kurki MI, Pietiläinen O, Hilpert M, Saarentaus E, Niinimäki J, Junttila J, Kaikkonen K, Vahteristo P, Skoda RC, Seppänen MRJ, Eklund KK, Taipale J, Kilpivaara O, Aaltonen LA. Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans. Nat Commun. 2019 Mar 19;10(1):1252.
Rajamäki K, Keskitalo S, Seppänen M, Kuismin O, Vähäsalo P, Trotta L, Väänänen A, Glumoff V, Keskitalo P, Kaarteenaho R, Jartti A, Hautala N, Jackson P, Nordström DC, Saarela J, Hautala T, Eklund KK**, Varjosalo M**. Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation. RMD Open. 2018 Oct 17;4 (2).
Glintborg, B, Lindström, U, Aaltonen K, Kristianslund E, Gudbjornsson B, Chatzidionysiou K, Askling J, Nordstrøm Dan, Hetland M, Di Giuseppe D, Dreyer L, Kristensen LE, Jørgensen TS, Eklund K, Grondal G, Ernestam S, Joensuu J, Törmänen M, Skydsgaard H, Hagfors J, Kvien, T, Kristian LE, Fagerli K, Geirsson A, Jonsson H, Provan S, Aarrestad K, Niels S, Jacobsson. Biological treatment in ankylosing spondylitis in theNordic countries during 2010-2016 A collaboration between five biological registries. Scand J Rheumatol. Aug 2:1-10. doi: 10.1080/03009742.2018.1444199. [Epub ahead of print].
Ainola M, Porola P, Takakubo Y, Przybyla B, Kouri VP, Tolvanen T, Hänninen A, Nordström Dan. Activation of plasmacytoid dendritic cells by apoptotic particles — mechanism for the loss of immunologic tolerance in Sjögren’s syndrome. Clin Exp Immunol 191:301-310, 2018.
Nieminen M, Listyarifah D, Hagström J, Haglund C, Grenier D, Nordström D, Uitto V-J, Hernandez M, Yucel-Lindberg T, Tervahartiala T, Ainola M, Sorsa T. Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation. Br J Cancer 118:428-434, 2018.
Barreto G, Soliymani R, Baumann M, Waris E, Eklund KK, Zenobi-Wong M, Lalowski M. Functional analysis of synovial fluid from osteoarthritic knee and carpometacarpal joints unravels different molecular profiles. Rheumatology (Oxford). 2018 Aug 2. doi: 10.1093/rheumatology/key232. [Epub ahead of print]
Kuusela E, , Kouri V-P, Olkkonen J, Koivuniemi R, Äyräväinen L, Rajamäki K, Valleala H, Nordström D, Leirisalo-Repo M, Ainola M, and Eklund KK. Serum Epstein-Barr virus DNA, detected by droplet digital PCR, correlates with disease activity in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2018 Mar 20. [Epub ahead of print].
Listyarifah D, Nieminen MT, Mäkinen LK, Haglund C, Grenier D, Häyry V, Nordström D, Hernandez M, Yucel-Lindberg T, Tervahartiala T, Ainola M, Sorsa T, Hagström J. Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features. J Oral Pathol Med May 47(8):764-772, 2018.
Salem A, Almahmoudi R, Listyarifah D, Siponen M, Maaninka K, Salo T, Al-Samadi A, Eklund KK. Histamine H4 receptor signaling in tongue cancer and its potential role in oral carcinogenesis - a short report. Cell Oncol (Dordr). 2017; 40(6):621-630.
Aaltonen K, Ylikylä S, Joensuu J, Isomäki P, Pirilä L, Kauppi M, Rannio T, Eklund KK, and Nordström DD. Efficacy and effectiveness of tumour necrosis factor –inhibitors in the treatment of rheumatoid arthritis factor with comparison between randomized controlled trials and routine clinical practise – prospective cohort study. Rheumatology (Oxford). 2017;56(5):725-735
Pérez-Tanoira R, Aarnisalo AA, Eklund KK MD, Xia Han X, Antti Soininen A, Tiainen V-M, Esteban J Kinnari TJ. Prevention of biomaterial infetion by preoperative incubation with human cells. Surg Infect (Larchmt). 2017; 18(3):336-344.
Nurmi K, Kareinen I, Virkanen J, Rajamäki K, Kouri VP, Vaali K, Levonen AL, Fyhrquist N, Matikainen S, Kovanen PT, Eklund KK. Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation. J Innate Immun. 2017;9(1):65-82.
Salem A, Rozov S, Al-Samadi A, Listyarifah D, Kouri VP, NordströmD, Hagström J, Eklund KK. Altered Expression of Toll-Like Receptors in Human Oral Epithelium in Oral Lichenoid Reactions. Am J Dermatopathol. 2017 Nov;39(11):811-818.
Kaustio M, Haapniemi E, Göös H, Hautala T, Park G, Syrjänen J, Einarsdottir E, Sahu B, Kilpinen S, Rounioja S, Fogarty C, Glumoff V, Kulmala P1, Katayama S, Tamene F, Trotta L, Morgunova E, Krjutshkov K, Nurmi K, Eklund K, Lagerstedt A, Helminen M, Martelius T, Mustjoki S, Taipale J, Saarela J, Kere J, Varjosalo M, and Seppänen M. Damaging heterozygous mutations in NFKB1 lead to diverse immunological phenotypes. J Allergy Clin Immunol. 2017;140(3):782-796
Olkkonen J Kouri V-P, Kusela E, Ainola M, Nordström D, Eklund KK, Mandelin J. DEC2 blocks efficiently the effect of ARNTL2/NPAS2 dimer on the expression of PER3 and DBP". J Circadian Rhythms. 2017;15:6.
Nieminen HJ, Barreto G, Finnilä MA, García-Pérez A, SalmiA, Ranjan S, Eklund KK, Pritzker KPH, Saarakkala S, Hæggström E. Laser-ultrasonic delivery of agents into articular cartilage. Scientific Reports, 2017;7(1):3991.
Barreto G, Sandelin J, Salem A, Nordström DC, Waris E. Toll-like receptors and their soluble forms differ in the knee and thumb basal osteoarthritic joints. Acta Orthop. 2017;88(3):326-333.
Salem A, Rozov S, Al-Samadi A, Stegajev V, Listyarifah D, Kouri VP, Han X, Nordström D, Hagström J, Eklund K. Histamine metabolism and transport are deranged in human keratinocytes in oral lichen planus. Br J Dermatol. 2017;176(5):1213-1223.
Lorey MB, Rossi K, Eklund KK, Nyman TA, Matikainen S. Global characterization of proteins secretion from human macrophages following non-canonical caspase-4/5 inflammasome activation. Mol Cell Proteomics. 2017;16(4 suppl 1):S187-S199.
Jämsen E, Kouri VP, Ainola M, Goodman SB, Nordström DC, Eklund KK, Pajarinen J. Correlations between macrophage polarizing cytokines, inflammatory mediators, osteoclast activity, and toll-like receptors in tissues around aseptically loosened hip implants. Biomed Mater Res A. 2017;105(2):454-463.
Pérez-Tanoira R, Han X, Soininen A, Aarnisalo AA, Tiainen VM, Eklund KK, Esteban J, Kinnari TJ. Competitive colonization of prosthetic surfaces by staphylococcus aureus and human cells. J Biomed Mater Res A. 2017;105(1):62-72.
Hartman O, Kovanen PT, Lehtonen J, Eklund KK, Sinisalo J. Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial. Eur Heart J Cardiovasc Pharmacother. 2017;3(2):92-97.