Lab members of the Genome Stability Group
Liisa Kauppi

Principal Investigator

PhD, Associate Professor

Haartmaninkatu 8 (PO Box 63)
00014 University of Helsinki

Phone: +358 2941 25555

Sanna Pikkusaari

PhD Student

Project: Sensitizing DNA repair proficient ovarian cancer cells to chemotherapy

My research focuses on DNA damage repair, especially homologous recombination (HR) repair, in high-grade serous ovarian cancer (HGSOC). In our lab, we have established an immunofluorescence-based assay to detect HR deficiency in HGSOC tumor cells. By utilizing this assay, my aim is to find a way to (re-)sensitize cancer cells to chemotherapy by manipulating HR repair pathway.


Fatih Genç

PhD Student

Project: LINE-1 retrotransposition dynamics in high-grade serous ovarian cancer

LINE-1 are transposable elements that comprise approximately 17% of human DNA. Even though silent in normal cells, LINE-1s are transcriptionally active in different types of cancer, often resulting in de novo insertions and therefore conducting to genomic instability. I am interested to understand the genomic evolution of LINE-1 activity in high-grade serous ovarian cancer.


Oussama (Sam) Krami Senhaji

PhD student

There is recent, mounting evidence that bacteria and viruses play a previously unappreciated role in cancer development and response to therapy. Microbiota encompasses a wide variety of microorganisms (bacteria, viruses, fungi) and has gathered increasing attention regarding their role in carcinogenesis.  Our objective is to provide a new perspective into the molecular behavior of high-grade serous ovarian carcinoma (HGSOC), by studying the presence and role of bacteria and viruses in causing DNA damage, and to present novel target treatments aimed towards bacteria and viruses to improve the clinical outcome of this disease.


Anu Anil

PhD student

Project: Targeting CCNE1 Amplification in HGSOC
Centered on high-grade serous ovarian cancer (HGSOC), my research is rooted in the pivotal role of DNA damage and its targeted treatments. My research aims to tackle CCNE1 amplification in HGSOC, a genetic alteration present in at least 20% of the HGSOC patients. My dedication centers on understanding the molecular intricacies underlying CCNE1 amplification and its impact on HGSOC progression. Given that existing therapies are efficient solely in HR-deficient tumors, I aim to delve into synthetic lethality approaches specifically tailored for HR-proficient tumor cells harboring CCNE1 amplification.


Srividhya Sundaresan

Transmed student

The goal of my project is to understand the temporal location of the DNA damage (% in S phase), the differences in the tumour microenvironment (TME) between HR-deficient and HR-proficient tumours and propose avenues for alternative treatment strategies.


Minna Eriksson

Lab manager


Phone: 0504489442


Ezgi Karagöz

Technical Assistant

My current project aims to investigate the effect of pre-fixation time on functional testing of HR (homologous recombination), using various fixation time points on samples obtained from Primary Debulking Surgery (PDS). Additionally, the research seeks to explore whether time-to-fixation extends its influence to other predictive and diagnostic tests.


Filippa Tallqvist

Master's student

A knock-out mouse model (Dnah3-/-) previously generated in the lab displays sperm immotility and consequently also male infertility. In my project, I use FinnGen data to see if genomic variants in the Dnah3 gene also lead to infertility and/or subfertility in Finnish men. Moreover, I analyze FinnGen DNA sequence data from men with the appropriate phenotypes and then compare this data to healthy controls. 


Kauppi lab alumni

Miia Kaistamaa, MD

Kul Shrestha, PhD

Manuela Tumiati, PhD

Nanna Sarvilinna, PhD

Imrul Faisal, PhD

Linlin Zhang, MD, PhD

Susanna Jonkka, MSc

Denis Dermadi Bebek, PhD

Vanessa Keser, ERASMUS student

Venkatram Yellapragada, MSc 

Martyna Salciute, BSc

Elli Aska, PhD

Jasmin Grönman, MSc

Juha Matilainen, PhD 

Barun Pradhan, post-doc

Henrik Talsi, summer student 

Oona Mehtälä, summer student

Maarit Hakkarainen, lab technician

Taina Turunen, lab technician

Minna Tuominen, lab manager

Saundarya Shah, lab manager