Haartmaninkatu 8 (PO Box 63)
00014 University of Helsinki
Phone: +358 2941 25555
E-mail: liisa.kauppi@helsinki.fi
About 50% of the human genome is derived from transposable elements or “jumping genes” that copied its sequence and inserted into a novel genomic location. Out of different families of transposable elements, Long Interspersed Nuclear Elements or LINE-1s are the only autonomously mobile element in the human genome. Although over 500,000 copies of LINE-1s exist in the human genome, approximately only 100 of them can move. As LINE-1s actively move in different cancer genomes, my research focuses on finding which LINE-1s are particularly active in high-grade serous ovarian cancer and where do de novo LINE-1 insertions occur in the cancer genome.
E-mail: barun.pradhan@helsinki.fi
My research focuses on mutational dynamics shaped by DNA mismatch repair. I am interested in why and where replication errors accumulate, and on the other hand, are repaired in different tissues and cell types.
E-mail: elli.aska@helsinki.fi
My research focuses on DNA damage repair, especially homologous recombination (HR) repair, in high-grade serous ovarian cancer (HGSOC). In our lab, we have established an immunofluorescence-based assay to detect HR deficiency in HGSOC tumor cells. By utilizing this assay, my aim is to find a way to (re-)sensitize cancer cells to chemotherapy by manipulating HR repair pathway.
E-mail: sanna.pikkusaari@helsinki.fi
LINE-1 are transposable elements that comprise approximately 17% of human DNA. Even though silent in normal cells, LINE-1s are transcriptionally active in different types of cancer, often resulting in de novo insertions and therefore conducting to genomic instability. I am interested to understand the genomic evolution of LINE-1 activity in high-grade serous ovarian cancer.
E-mail: fatih.genc@helsinki.fi
E-mail: saundarya.shah@helsinki.fi
Miia Kaistamaa, MD
Kul Shrestha, PhD
Manuela Tumiati, PhD
Nanna Sarvilinna, PhD
Imrul Faisal, PhD
Linlin Zhang, MD, PhD
Susanna Jonkka, MSc
Denis Dermadi Bebek, PhD
Vanessa Keser, ERASMUS student
Venkatram Yellapragada, MSc
Juha Matilainen, PhD
Henrik Talsi, summer student
Maarit Hakkarainen, lab technician
Taina Turunen, lab technician
Minna Tuominen, lab manager