We aim to develop models for early identification of individuals at high risk for cognitive impairment and dementia and to predict conversion from mild cognitive impairment to Alzheimer’s Disease.
The pathways from protective and risk factors to old age cognition are not well known. Twin design allows to investigate genetic and environmental effects between risk factors and old age cognition. Co-twin analyses of twins discordant for genetic or middle age life style factors can inform more about causality of these associations.
We will study cognitive aging in the oldest-old twins who have participated in the older Finnish Twin Cohort.