Doctoral dissertations

2018

• Mikko Holmberg Pharmacokinetic Interactions and Pharmacogenetics of Clopidogrel, Prasugrel and Ticagrelor.

2017

• Katriina Tarkiainen Pharmacogenetics of Carboxylesterase 1.

2016

• Juho Heinonen Intravenous lipid emulsion for treatment of local anaesthetic and tricyclic antidepressant toxicity.

2015

• Päivi Ruokoniemi From statin efficacy to everyday effectiveness: Studying the gap in between.

2014

• Anne Filppula Role of CYP2C8 in the metabolism of montelukast and imatinib – Studies in vitro, in silico and in humans.

2012

• Tuija Tapaninen Pharmacokinetic interactions and pharmacogenetics of aliskiren.
• Tiina Karonen Pharmacokinetics of montelukast and zafirlukast as affected by CYP inhibitors.
• Erik Litonius Treatment of acute intoxication with intravenous lipid emulsion : animal and human studies.

2011

• Johanna Honkalammi Mechanism-based inhibition of CYP2C8 by gemfibrozil in humans: characterisation of time and dose relationships.
• Xiaoqiang Xiang Effects of gender, and SLCO1B1 and CYP7A1 polymorphisms on plasma bile acids in humans and the pharmacokinetics of therapeutic ursodeoxycholic acid.

2009

• Marjo Volotinen Expression of cytochrome P450-enzymes and metabolism of timolol in human ocular tissue.
• Samuel Fanta Cyclosporine population pharmacokinetics in pediatric renal transplant recipients.
• Mika Isohanni Cytochrome P450-mediated drug interactions affecting lidocaine.

2008 

• Annikka Kalliokoski Effects of SLCO1B1 polymorphism on the pharmacokinetics of the oral antidiabetic drugs repaglinide, nateglinide, rosiglitazone, and pioglitazone.
• Marjo Karjalainen Inhibition of CYP1A2-mediated drug metabolism in vitro and in humans with special emphasis on rofecoxib and other NSAIDs.
• Henna Rautiainen Epidemiology and Treatment Options of Primary Biliary Cirrhosis.
• Kati Ahonen Study of sleep and evaluation of sumatriptan and rizatriptan in the acute treatment of migraine in children and adolescents.
• Kim Lemberg The Pharmacology of Oxycodone: Studies In Vitro, In Vivo and In Humans
• Marja Pasanen Pharmacogenetics of SLCO1B1: Population genetics and effect on statins.
• Aleksi Tornio Studies on CYP2C8-mediated drug interactions

2007

• Tiina Jakkola Pharmacokinetic interactions of pioglitazone

2006 

• Lauri Kajosaari Pharmacokinetic interactions affecting the antidiabetic repaglinide.
• Mia Koskinen Pharmacokinetics, efficacy, and safety of pravastatin in children: Studies in children with heterozygous familial hypercholesterolemia and in pediatric cardiac transplant recipients.
• Pentti Pöder Levosimendan in patients with ischaemic heart disease.

2005

• Marika Granfors Interactions of tizanidine with CYP1A2 enzyme inhibitors – studies in vitro and in humans.
• Heli Malm The use and risks of prescription drugs during pregnancy.
• Heikki Valleala Bisphosphonates in the treatment of rheumatoid arthritis with special reference to collagen degradation.

2004

• Carl Kyrklund Effects of gemfibrozil and rifampicin on the pharmacoikinetics of HMG-CoA reductase inhibitors.

2003

• Hanna Kotikoski Effects of nitric oxide donors and cyclic GMP on intraocular pressure and aqueous humor dynamics.
• Kristiina Perttunen Pain after throracic surgery.
• Mika Jokinen Effects of drug interactions and liver disease on the pharmacokinetics of ropivacaine.
• Matti Kivikko Hemodynamic effects and pharmacokinetics of levosimendan and its metabolites in patients with severe heart failure.
• Kari Raaska Pharmacokinetic interactions of clozapine in hospitalized patients.

2002

• Xia Wen In vitro approaches in evaluation and prediction of drug-drug interactions involving the inhibition of cytochrome P450 enzymes.

2001

• Outi Lapatto-Reiniluoto Acute poisonings: Epidemiology and gastrointestinal decontamination.
• Elina Saarenmaa Analgesia for newborn infants during mechanical ventilation.
• Jun-Sheng Wang In vivo and in vitro studies on drug metabolism and interactions involving mibefradil, isradipine, lidocaine, selegiline and metronidazole.
• Jari Lilja Effects of grapefruit juice on the pharmacokinetics of selected CYP3A4 substrate drugs.
• Mikko Niemi Effects of induction and inhibition of cytochrome P-450 enzymes on the pharmacokinetics and pharmacodynamics of oral antidiabetic drugs.

2000

• Tiina Varis Studies on drug interactions between CYP3A4 inhibitors and glucocorticoids.

1999

• Teemu Kantola, Effects of itraconazole and some other CYP3A4 inhibitors on the pharmacokinetics of HMG-CoA reductase inhibitors.
• Vilja Palkama, Studies on drug interactions between CYP3A4 inhibitors and anaesthetic drugs.
• Kirsti Villikka, Studies on drug interactions caused by rifampicin and dexamethasone in humans.

1998 

• Tommi Lamberg, Effects of inhibition and induction of CYP3A4 on the pharmacokinetics and pharmacodynamics of buspirone.

1997

• Mirja Hämäläinen, L: Optimal drug treatment of recurrent headaches and migraine in children – a clinical and pharmacological study.
• Kirsi-Maija Kaukonen, Studies on the effects of a CYP3A4-inhibitor, itraconazole, on the pharmacokinetics and pharmacodynamcis of cardiovascular drugs.
• Seppo Kähkönen, Pharmacodynamic and pharmacokinetic aspects of propranolol, verapamil and isosorbide dinitrate during alcohol withdrawal.
• Eeva Lukkari, Clinical pharmacology of oxybutynin, with special reference to pharmacokinetics and interaction.

1996

• Reijo Laaksonen, The effect of HMG-CoA reductase inhibitor treatment on serum and skeletal muscle ubiquinone.
• Jouni Ahonen, Studies on CYP3A mediated drug interactions in anaesthesiology.
• Ari Illi, Inhibition of catechol-O-methyltransferase by entacapone: Effects on haemodynamics and catecholamine metabolism and interactions with drugs interfering with catecholamine disposition.
• Harri Luurila, Effect of erythromycin on the pharmacokinetics and pharmacodynamics of hypnotics.
• Anu Varhe, Interactions of triazolam with inhibitors of CYP3A enzymes.

1995

• Janne Backman, Effects of drugs inhabiting and inducing CYP3A enzymes on the pharmacokinetics and pharmacodynamics of oral midazolam.

1994

• Tapio Kuitunen

1993

• Anne Lamminpää

1990

• Riitta Tokola, Studies on drug absorption and efficacy in migraine attacks.

1989

• Olavi Tokola

1987

• Kalle Hoppu, Paediatric clinical pharmacology of trimethoprim.

1987

• Eero Tiula, Effect of renal diseases on serum protein binding of drugs.

1985

• Klaus Olkkola, Factors affecting the antidotal efficacy of oral activated charcoal.

1982

• Jaakko-Juhani Himberg, Optimization and validation of gas-chromatographic drug assays for pharmacokinetic studies.

1981

• Mirja-Liisa Aitio

1980

• Sirkka Elfving, Studies on the naturally occurring goitrogen 5-vinyl-2-thiooxazolidone – metabolism and antithyroid effect in the rat.