Montrose K, Lac DT, Burnetti AJ, Tong K, Bozdag GO, Hukkanen M, Ratcliff WC, Saarikangas J. Proteostatic tuning underpins the evolution of novel multicellular traits. Science Advances, 10, eadn2706, 2024.
Carabalona A, Kallo H, Gonzalez M, Andriichuk L, Elomaa E, Molinari F, Fragkou C, Lappalainen P, Wessels MW, Saarikangas J, Rivera C (2024) Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA. eLife 13:RP92748, 2024.
Paukštytė J, López Cabezas RM, Feng Y, Tong K, Schynder D, Elomaa E, Gregorova P, Doudin M, Särkkä M, Sarameri J, Lippi A, Vihinen H, Juutila J, Nieminen A, Törönen P, Holm L, Jokitalo E, Krisko A, Huiskonen J, Hietakangas V, Picotti P, Barral Y, Saarikangas J. Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity. Molecular Cell, 83 (18):3360-3376.e11, 2023.
Senju Y, Mustaq T, Vihinen H, Manninen A, Saarikangas J, Ven K, Engel U, Varjosalo M, Jokitalo E, Lappalainen P. Actin-rich lamellipodia-like protrusions contribute to the integrity of epithelial cell–cell junctions. Journal of Biological Chemistry, 299 (5), 104571, 2023.
Oamen HP, Romero N, Knuckles P, Saarikangas J, Radman-Livaja M, Dong Y and Caudron F. A rare natural lipid induces neuroglobin expression to prevent amyloid oligomers toxicity and retinal neurodegeneration. Aging Cell, 21 (7), e13645, 2022.
Lau Y, Oamen HP, Grogg M, Parfenova I, Saarikangas J, Hannay R, Nichols RA, Hilvert D, Barral Y, and Caudron F. Whi3 mnemon association with endoplasmic reticulum membranes confines the memory of deceptive courtship to the yeast mother cell. Current Biology 32, 963–974, 2022.
van Oosten-Hawle P and Saarikangas J. Special Issue on Cell Stress in Development and Disease. Experimental Cell Research 408:112839, 2021.
Montrose K, Lopez-Cabezas RM, Paukstyte J, Saarikangas J. Winter is coming: Regulation of cellular metabolism by enzyme polymerization in dormancy and disease. Experimental Cell Research. 397:112383, 2020.
Kettunen P, Baumann M, Saarikangas J. Proteiinien laskostumishäiriöt aivojen rappeumasairauksissa. Duodecim.137:811-20, 2021.
Sawarkar R, Scherz-Shouval R, Denzel M, Saarikangas J. Chaperoning junior faculty. EMBO Reports 20:e47163, 2019.
Sawarkar R, Scherz-Shouval R, Denzel M, Saarikangas J. Preparing junior faculty for success. Science 361: 238, 2018.
Saarikangas J, Hotulainen P. Hermosolujen synapsien muovautumismekanismit oppimisen, muistin ja aivojen rappeumasairauksien taustalla. Duodecim. 134:1226-34, 2018.
Saarikangas J, Caudron F. Spatial Regulation of Coalesced Protein Assemblies: Lessons from Yeast to Diseases. Prion. 27:1-12, 2017.
Saarikangas J, Caudron F, Prasad R, Moreno DF, Aldea M, Barral Y. ER compartmentalization confines protein aggregation to the aging lineage during asymmetric cell division. Current Biology. 27: 773-783, 2017.
Saarikangas J, Barral Y. Protein aggregation as a mechanism for adaptive cellular responses. Current Genetics. 62: 711-724, 2016.
Hotulainen P, Saarikangas J. The initiation of post-synaptic protrusions. Communicative & Integrative Biology. 12; 9:e1125053, 2016.
Saarikangas J, Barral Y. Protein aggregates are associated with replicative aging without compromising protein quality control. eLife. 4:e06197, 2015.
Saarikangas J, Kourdougli N, Chazal N, Kuurne J, Senju Y, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Lappalainen P, Rivera C and Hotulainen P. Dendritic spines are initiated by MIM induced membrane curvature. Developmental Cell. 33: 644-59, 2015.
Mertz KD, Pathria G, Wagner G, Saarikangas J, Sboner A, Romanov J, Gschaider M, Lenz F, Neumann F, Schreiner W, Nemethova M, Glassmann A, Lappalainen P, Stingl G, Small JV, Fink D, Chin L, Wagner SN. MTSS1 is a Metastasis Driver in a Subset of Human Melanomas. Nature Communications. 17;5:3465, 2014.
Maddugoda MP, Stefani C, Gonzalez-Rodriguez D, Saarikangas J, Torrino S, Janel S, Prodon F, Doye A, Goossens PL, Lafont F, Bassereau P, Lappalainen P, Brochard F and Lemichez E. cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. Cell Host and Microbe. 10:464-74, 2011.
Saarikangas J and Barral Y. The Emerging Functions of Septins in Metazoans. EMBO Reports. 12: 11188-26. 2011.
Pykalainen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela E, Peranen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R, Lappalainen P. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nature Structural and Molecular Biology. 18:902-7, 2011.
Saarikangas J, Mattila P.K, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, Hrabé de Angelis M, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M and Lappalainen P. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. Journal of Cell Science. 124:Pt8: 1245-55, 2011.
Saarikangas J, Zhao H and Lappalainen P. Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides. Physiological Reviews. 90 (1) 2010.
Saarikangas J, Zhao H, Pykalainen A, Laurinmaki P, Mattila PK, Kinnunen PK, Butcher SJ and Lappalainen P. Molecular mechanisms of membrane deformation by I-BAR domain proteins. Current Biology. 19: 2: 95-107, 2009.
Saarikangas J, Hakanen J, Mattila PK, Grumet M, Salminen M and Lappalainen P. ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension. Journal of Cell Science. 121: Pt 9: 1444-1454, 2008.
Mattila PK, Pykalainen A, Saarikangas J, Paavilainen VO, Vihinen H, Jokitalo E and Lappalainen P. Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism. Journal of Cell Biology. 176: 7: 953-964, 2007.