Protein homeostasis and neurodegeneration

We are interested in BRAIN✓REPAIR after injury and neurodegeneration, aiming to find new mechanisms and ways to restore and regenerate the damaged brain.

The ultimate long-term goal is to develop disease-modifying therapies. We are curious about endoplasmic reticulum protein homeostasis in regulating the function of a brain cell in health and disease. We aim to understand myeloid cell and neuron interactions and study the mechanisms of protein aggregation (alpha-synuclein) and spreading. We have developed new unbiased ways for high-content image analysis to quantify numbers of neurons, Lewy bodies and neurites. We work with cell cultures (primary, immortalized, iPSC-derived neurons), disease models, and CRISPR-based genome editing to develop quantitative tools to measure pharmacological processes in cell culture and in vivo.

We have a passion for excellent-level research and high-quality international training. With international collaborators, we can push the frontiers of science. Our mission is to provide the highest quality science-based teaching and training. By finding out what is the thing you are most interested in, and then grasping the opportunity you can shape the future.