J. Matović, J. Järvinen, H. C. Bland, I. K. Sokka, S. Imlimthan, R. M. Ferrando, K. M. Huttunen, J. Timonen, S. Peräniemi, O. Aitio, A. J. Airaksinen, M. Sarparanta, M. P. Johansson, J. Rautio, F. S. Ekholm, Addressing the Biochemical Foundations of a Glucose-based “Trojan horse”–strategy to Boron Neutron Capture Therapy: From Chemical Synthesis to In Vitro Assessment, Mol. Pharmaceutics 2020, accepted.

A. A. Hettikankanamalage, R. Lassfolk, F. S. Ekholm, R. Leino, D. Crich, Mechanisms of stereodirecting participation and ester migration from near and far in glycosylation and related reactions, Chem. Rev. 2020, 120, 7104–7151.

R. O. Paananen, T. Viitaja, A. Olzynska, F. S. Ekholm, J. Moilanen, L. Cwiklik, Interactions of polar lipids with cholesteryl ester multilayers elucidate tear film lipid layer structure, Ocul. Surf. 2020, 18, 545–553.

J. Siirilä, S. Hietala, F. S. Ekholm, H. Tenhu, Glucose and maltose surface functionalized thermoresponsive poly(N-vinylcaprolactam) nanogels, Biomacromolecules 2020, 21, 955–965.

I. K. Sokka, F. S. Ekholm, M. P. Johansson, Increasing the potential of the auristatin cancer-drug family by shifting the conformational equilibrium, Mol. Pharmaceutics 2019, 16, 3600–3608.

S.-K. Ruokonen, F. S. Ekholm, S. K. Wiedmer, Assessing interactions of auristatin derivatives with mixed phospholipid-sodium dodecyl sulfate aggregate dispersions, Langmuir 2019, 35, 5232–5240.

H. C. Bland, J. A. Moilanen, F. S. Ekholm, R. O. Paananen, Investigating the Role of Specific Tear Film Lipids Connected to Dry Eye Syndrome: A Study on O-acyl-ω-hydroxy-fatty acids and Diesters, Langmuir 2019, 35, 3545–3552 (ACS Editors' Choice article).

R. Lassfolk, J. Rahkila, M. P. Johansson, F. S. Ekholm, J. Wärnå, R. Leino, Acetyl group migration across saccharide units in oligomannoside model compounds, J. Am. Chem. Soc. 2019, 141, 1646–1654.

F. S. Ekholm, S.-K. Ruokonen, M. Redón, V. Pitkänen, A. Vilkman, J. Saarinen, J. Helin, T. Satomaa, S. K. Wiedmer, Hydrophilic Monomethyl Auristatin E derivatives as novel candidates for the design of antibody-drug conjugates, Separations 2019, 6, 1.

 J. Rahkila, F. S. Ekholm, A. Ardá, S. Delgado, J. Savolainen, J. Jiménez-Barbero, R. Leino, Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Probing the Carbohydrate – Protein Interactions of Gal-3, ChemBioChem 2019, 20, 203–209.

 J. Rahkila, F. S. Ekholm, R. Leino, Cu(I) mediated degradation of polysaccharides leads to fragments with narrow polydispersities, Eur. J. Org. Chem. 2018, 1449–1454.

F. S. Ekholm, R. Leino, chapter 8: “Acyl migrations in carbohydrate chemistry” in the book; “Protective groups – Strategies and Applications in Carbohydrate Chemistry” (Ed. S. Vidal), Publisher: Wiley-VCH.


M. P. Johansson, H. Maaheimo, F. S. Ekholm, New insights on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling, Sci. Rep. 2017, 7:15290.

K. Lagerblom, E. Lagerspets, J. Keskiväli, C. Cook, F. Ekholm, A. Parviainen, T. J. Repo, Practical aerobic oxidation of alcohols: ligand enhanced TEMPO/Mn(NO3)2 catalyst system, ChemCatChem 2017, 20, 3880–3887.

F. S. Ekholm, H. Pynnönen, A. Vilkman, V. Pitkänen, J. Helin, J. Saarinen, T. Satomaa, Introducing glycolinkers for the functionalization of cytotoxic drugs and applications in antibody-drug conjugation chemistry, ChemMedChem 2016, 11, 2501–2505.

F. S. Ekholm, H. Pynnönen, A. Vilkman, J. Koponen, J. Helin, T. Satomaa, Synthesis of the copper chelator TGTA and evaluation of its ability to protect biomolecules from copper induced degradation during copper catalyzed azide-alkyne bioconjugation reactions, Org. Biomol. Chem. 2016, 14, 849–852.

J. Helin, J. Saarinen, T. Satomaa, F. S. Ekholm, Saccharide derivative of a toxic payload and antibody conjugates thereof, WO/2016/001485 (A1), Glykos Finland Ltd

A. Leppänen, F. S. Ekholm, J. Helin, H. Salo, A. Kanerva, Conjugate, JP/2016/020336 (A), US/2017/112931 (A1), Tenboron Ltd


J. Helin, J. Saarinen, F. S. Ekholm, A. Leppänen, Payload-polymer-protein conjugates, WO/2015/15189478 (A1), US/2017/189549 (A1), Glykos Finland Ltd


J. Rahkila, F. S. Ekholm, R. Panchadhayee, A. Ardá, F. J. Cañada, J. Jiménez Barbero, R. Leino, Synthesis and conformational analysis of phosphorylated β-(1→2)-linked mannosides, Carbohydrate Res. 2014, 383, 58–68.

T. Satomaa, J. Helin, F. S. Ekholm, Conjugates of a glycoprotein or a glycan with a toxic payload, WO/2014/177771 (A1); US/2016/106860 (A1), Glykos Finland Ltd

F. S. Ekholm, T. Satomaa, J. Helin, H. Pynnönen, Linker-payload molecule conjugates, WO/2014/096551 (A1); US/2015/314007 (A1), Glykos Finland Ltd

F. S Ekholm, Á. Berényi, L. Lagerquist, T. Saloranta, I. Zupkó, G. Schneider, J. Wölfling, R. Leino, Cytotoxic activity of some glycoconjugates including saponins and anthracyclines, Carbohydrate Res. 2012, 356, 295–298.

K. Ranta, K. Nieminen, F. S. Ekholm, M. Poláková, M. U. Roslund, T. Saloranta, R. Leino, J. Savolainen, Evaluation of the immunostimulatory activities of synthetic mannose containing structures mimicking β-(1,2)-linked cell wall mannans of Candida albicans, Clin. Vaccine Immunol. 2012, 19, 1889–1893.

F. S. Ekholm, A. Ardá, P. Eklund, S. André, H.-J. Gabius, J. Jiménez-Barbero, R. Leino, Studies related to Norway spruce galactoglucomannans: chemical synthesis, conformational analysis, NMR spectroscopic characterization and molecular recognition of model compounds, Chem. Eur. J. 2012, 18, 14392–14405.

F. S. Ekholm, G. Schneider, J. Wölfling, R. Leino, An Approach to the Synthesis and Attachment of Scillabiose to Steroids, Steroids 2011, 76, 588–595.

F. S. Ekholm, L. Lagerquist, R. Leino, Stereo- and regioselective glycosylation of 4-deoxy-e-rhodomycinone, Carbohydrate Res. 2011, 346, 858–862.

F. S. Ekholm, G. Schneider, J. Wölfling, R. Leino, Synthesis of a small library of estradiol based glycosteroid mimics containing a modified D-ring, Eur. J. Org. Chem. 2011, 1064–1077.

F. S. Ekholm, I. Mandity, F. Fülop, R. Leino, Rapid, simple and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry, Tetrahedron Lett. 2011, 52, 1839–1841.

F. S. Ekholm, J. Sinkkonen, R. Leino, Fully deprotected β-(1→2)-mannotetraose forms a contorted α-helix in solution: convergent synthesis and conformational characterization by NMR and DFT, New. J. Chem. 2010, 34, 667–675.

A. Hietanen, F. S. Ekholm, R. Leino, L. T. Kanerva, Applying biocatalysis to the synthesis of diastereomerically enriched cyanohydrin Mannosides, Eur. J. Org. Chem. 2010, 6974–6980.

F. S. Ekholm, P. Eklund, R. Leino, A short semi-synthesis and complete NMR-spectroscopic characterization of the naturally occurring lignan glycoside matairesinol 4,4'-di-O-β-D-glucoside, Carbohydrate Res. 2010, 345, 1963–1967.

M. Poláková, M. U. Roslund, F. S. Ekholm, T. Saloranta, R. Leino, Synthesis of β-(1→2)-linked mannosides, Eur. J. Org. Chem. 2009, 870–888.  

F. S. Ekholm, M. Poláková, A. J. Pawłowicz, R. Leino, Synthesis of divalent 2,2'-linked mannose derivatives by homodimerization, Synthesis 2009, 567–576.