Highlighted publications

Zachari M, Gudmundsson SR*, Li Z*, Manifava M*, Shah R, Smith M, Stronge J, Karanasios E, Piunti C, Kishi‐Itakura C, Vihinen H, Jokitalo E, Guan J-L, Buss F, M. Smith AM, Walker SA, Eskelinen E-L, Ktistakis NT: Selective autophagy of mitochondria on a ubiquitin‐endoplasmic reticulum platform. Dev Cell 2019 (Epub July 15). DOI: 10.1016/j.devcel.2019.06.016

https://www.sciencedirect.com/science/article/pii/S1534580719305696?via%3Dihub

 

Anwar T, Liu X, Suntio T, Marjamäki A, Biazik J, Chan EYW, Varjosalo M, Eskelinen EL: ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases. Cells. 2019 May 17;8(5). DOI: 10.3390/cells8050475.

https://www.mdpi.com/2073-4409/8/5/475

 

Syrjä P, Anwar T, Jokinen TS, Kyöstilä K, Hultin-Jäderlund K, Cozzi F, Rohdin C, Hahn K, Wohlsein P, Baumgärtner W, Henke D, Oevermann A, Sukura A, Leeb T, Lohi H, Eskelinen E-L: Basal Autophagy is altered in Lagotto Romagnolo Dogs with an ATG4D mutation. Veterinary Pathology 2017, 54:953-963. DOI: 10.1177/0300985817712793

http://journals.sagepub.com/toc/vet/0/0

 

Biazik J, Vihinen H, Jokitalo E, Eskelinen E-L: Untrastructural characterization of phagophores using electron tomography on cryoimmobilized and freeze substituted samples. Methods Enzymol 2017, 587:331-349.

DOI.org/10.1016/bs.mie.2016.09.063 http://dx.doi.org/10.1016/bs.mie.2016.09.063

 

Ylä-Anttila P, Mikkonen E, Happonen KE, Holland P, Ueno T, Simonsen A, Eskelinen E-L: RAB24 facilitates clearance of autophagic compartments during basal conditions. Autophagy 2015, 11:1833-48. DOI:10.1080/15548627.2015.1086522.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824578/

 

Biazik J, Ylä-Anttila P, Vihinen H, Jokitalo E and Eskelinen E-L: Ultrastructural relationship of the phagophore with surrounding organelles. Autophagy 2015, 11:439-451. DOI:10.1080/15548627.2015.1017178.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502653/

 

Ylä-Anttila P, Vihinen H, Jokitalo E, Eskelinen E-L: 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 2009, 5:1180-1185

http://www.tandfonline.com/doi/abs/10.4161/auto.5.8.10274  

http://dx.doi.org/10.4161/auto.5.8.10274

Eskelinen E-L: Autophagy: supporting cellular and organismal homeostasis by self-eating. Int J Biochem Cell Biol 2019, 111:1-10.

https://doi.org/10.1016/j.biocel.2019.03.010

 

Millan M, Yu WH, Boland B, Cort O, Mollereau B, Henriques A, Bezard E, Pastores G, Rubinsztein D, Nixon R, Duchen M, Mallucci G, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, and Martin O: Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of aging. Nat Rev Drug Disc 2018, 17:660-688.

DOI:10.1038/nrd.2018.109

 

Ylä-Anttila P, Eskelinen EL: Roles for RAB24 in autophagy and disease. Small GTPases 2018 9:57-65. doi: 10.1080/21541248.2017.1317699.

https://www.ncbi.nlm.nih.gov/pubmed/28463543

 

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P2, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen E-L, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Koemer G: Molecular definition of autophagy and related processes. EMBO J 2017 36:1811-1836. DOI:10.15252/embj.201796697

http://emboj.embopress.org/content/36/13/1811.long

 

Biazik J, Vihinen H, Anwar T, Jokitalo E, Eskelinen E-L: The versatile electron microscope: an ultrastructural overview of autophagy. Methods 2015, 75:44-53. DOI: 10.1016/j.ymeth.2014.11.013.

http://www.sciencedirect.com/science/article/pii/S1046202314003764

 

Kaarniranta K, Meri S, Eskelinen E-L: Lääketieteen Nobelin palkinto autofagian tutkijalle / Nobel price in medicine to autophagy researcher. Duodecim 2016, 132:2141-2144. (in Finnish).

http://www.duodecimlehti.fi/lehti/2016/22/duo13396

 

Damme M, Suntio T, Saftig P, Eskelinen E-L: Autophagy in neuronal cells: General principles and physiological and pathological functions. Acta Neuropathologica 2015, 129:337-362. DOI:10.1007/s00401-014-1361-4.

http://link.springer.com/article/10.1007%2Fs00401-014-1361-4

 

Eskelinen E-L, Reggiori F, Baba M, Kovács AL, Seglen PO: Seeing is believing – The impact of electron microscopy on autophagy research. Autophagy 2011, 7:935-956.

http://www.tandfonline.com/doi/abs/10.4161/auto.7.9.15760

http://dx.doi.org/10.4161/auto.7.9.15760

 

Ylä-Anttila P, Vihinen H, Jokitalo E, and Eskelinen E-L: Monitoring autophagy by electron microscopy in mammalian cells. Methods Enzymol 2009, 452:143-164. DOI: 10.1016/S0076-6879(08)03610-0.

http://www.sciencedirect.com/science/article/pii/S0076687908036100

Pascall JC, Webb LMC, Eskelinen E-L, Innocentin S, Attaf N, and Butcher GW: GIMAP6 is required for T cell maintenance and efficient autophagy in mice. PLOS One 2018, 13:e0196504.  doi:10.1371/journal.pone.0196504

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196504

 

Tabara LC, Vicente JJ, Biazik J, Eskelinen E-L, Vincent O, and Escalante R: VMP1 marks ER subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution. Traffic 2018, 19:624-638. https://doi.org/10.1111/tra.12581

https://onlinelibrary.wiley.com/doi/abs/10.1111/tra.12581

 

Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI: Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z.

https://www.ncbi.nlm.nih.gov/pubmed/29343728

 

Kang C, Badr MA, Kyrychenko V, Eskelinen EL, Shirokova N: Deficit in PINK1/PARKIN-mediated mitochondrial autophagy at late stages of dystrophic cardiomyopathy. Cardiovasc Res. 2018 Jan 1;114(1):90-102. doi: 10.1093/cvr/cvx201.

https://www.ncbi.nlm.nih.gov/pubmed/29036556

 

Colecchia D, Stasi M, Leonardi M, Manganelli F, Nolano M, Veneziani BM, Santoro L, Eskelinen EL, Chiariello M, Bucci C: Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B. Autophagy. 2017 Nov 13:0. DOI: 10.1080/15548627.2017.1388475. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/29130394

 

Mandell MA, Jain A, Kumar S, Castleman MJ, Anwar T, Eskelinen E-L, Johansen T, Prekeris R, and Deretic V: TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation. J Cell Sci 2016, 129:3562-3573. DOI: 10.1242/jcs.190017.

http://jcs.biologists.org/content/129/19/3562.long

 

Frankel LB, Di Malta C, Wen J, Eskelinen E-L, Ballabio A and Lund AH: A non-conserved miRNA regulates lysosomal function and impacts on a human lysosomal storage disorder. Nature Communications 2014, 5:5840. DOI: 10.1038/ncomms6840.

http://www.nature.com/articles/ncomms6840

 

He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen E-L, Scherer PE, Whistler JL and Levine B: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell 2013, 154:1085-1099. DOI: 10.1016/j.cell.2013.07.035.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231430/

 

Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen E-L, Mizushima N, Ohsumi Y, Cattoretti G, Levine B: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy  gene.  J Clin Invest 2003, 112:1809-1820. DOI:10.1172/JCI200320039

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297002/

 

Melendez A, Talloczy Z, Seaman M, Eskelinen E-L, Hall DH, Levine B: Autophagy genes are essential for dauer development  and lifespan extension in C. elegans.  Science 2003, 301:1387-1391. DOI:10.1126/science.1087782.

http://science.sciencemag.org/content/301/5638/1387.long