Multiple sclerosis is a chronic neurological disease characterized by immune mediated damage to the protective myelin covering of the nerves in the brain and spinal cord. The nervous system's ability of signal transmission is disrupted and patients suffer from a range of symptoms such as double vision, vision loss, eye pain, muscle weakness, and loss of sensation or coordination.
We pioneer in exploring deep cervical lymph nodes of patients with Multiple sclerosis at the diagnostic phase by using fine needle aspirations. We perform single cell RNA sequencing, CITEseq, TCR/BCR analysis to understand the cellular milieu. Our collaborator MD PhD Maria Perdomo and her group utilize human DNA virome -tailored NGS to understand the role of viral infections in MS lymph nodes.
Myasthenia gravis is an autoimmune neurological disease caused by antibodies against components of the post synaptic muscle endplate at neuromuscular junction. It is characterized by muscle weakness and fatigue.
We investigate the pathophysiology of myasthenia gravis using Cyclic immunohistochemistry to decipher the germinal center reaction in secondary lymphoid organs.
We participate in a multicenter European consortium study OptiMyG where we deploy a systematic sample and clinical data collection to track disease subgroups and treatment effects.