Genomic information, mainly SNP-genotype data, is utilized in genome-wide association studies (GWAS), genomic selection methods and population genetics analyses. We have used Porcine 60K SNP chip data of Finnish pig breeds to investigate genetic basis of pork quality, lethal haplotypes and effective population size. Currently we exploit gene expression and targeted sequencing to validate our previously found candidate genes for pork quality. This is done in collaboration with the research group at the University of Bologna. In the Ayrshire dairy cattle, imputed 50K SNP-genotypes of over 10,000 Finnish cows have been used for estimating levels of genomic inbreeding.
Martikainen, K., Sironen, A. & Uimari, P. 2018. Estimation of intrachromosomal inbreeding depression on female fertility using runs of homozygosity in Finnish Ayrshire cattle. Journal of Dairy Science 101: 11097-11107. https://doi.org/10.3168/jds.2018-14805
Smaragdov, M.G., Kudinov, A.A. & Uimari, P. 2018. Assessing the genetic differentiation of Holstein cattle herds in the Leningrad region using Fst statistics. Agricultural and Food Science 27:96-101. https://journal.fi/afs/article/view/69777
Martikainen K., Tyrisevä A-M., Matilainen K., Pösö J. & Uimari P. 2017. Estimation of inbreeding depression on female fertility in the Finnish Ayrshire population. Journal of Animal Breeding and Genetics 134:383-392. http://dx.doi.org/10.1111/jbg.12285
Verardo L., Sevon-Aimonen M-L., Serenius T., Hietakangas V. and Uimari, P. 2017. Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs. BMC Genetics 18. http://dx.doi.org/10.1186/s12863-017-0482-x
Häggman J. and Uimari P. 2016. Novel harmful recessive haplotypes for reproductive traits in pigs. Journal of Animal Breeding and Genetics 134:129-135. http://dx.doi.org/10.1111/jbg.12240